Distribution and characterization of neuropeptide Y-like immunoreactivity in the brain and pituitary of the goldfish

Pontet, A.; Danger, Jean-Michel; Dubourg, P.; Pelletier, Georges; Vaudry, Hubert; Calas, A.; Kah, Olivier

doi:10.1007/bf00218788

Cited by 111 publications

(73 citation statements)

References 32 publications

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“…Taken in context with immunohistochemical data for teleosts [Kah and Chambolle, 1983;Ekström, 1987;Brantley and Bass, 1988;Northcutt and Wullimann, 1988;Pontet et al, 1989;Roberts et al, 1989;Sharma et al, 1989;Batten et al, 1990;Ekström et al, 1992;Vecino et al, 1992;Manso et al, 1993;Meek and Joosten, 1993;Meek, 1994;Ma, 1997;Anadón et al, 2002;Rink and Wullimann, 2002;Clemente et al, 2004], holosteans [Parent and Northcutt, 1982], and polypteriforms [Reiner and Northcutt, 1992], the present immunohistochemical analysis of the forebrain of the white sturgeon (a chondrostean) helps to clarify the evolution of the telencephalon in ray-finned fishes. Our results indicate that, based on the distribution and concentration of SP and LENK, there is a clear separation of the dorsal and ventral telencephalic areas that appear to correspond to the pallium and subpallium, respectively.…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical Organization of the Forebrain in the White Sturgeon, Acipenser transmontanus

Piñuela

Northcutt

2007

Brain Behav Evol

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The distribution of substance P (SP), leucine-enkephalin (LENK), serotonin (5HT), dopamine (DA), and tyrosine hydroxylase (TH) was examined in the forebrain of the white sturgeon in order to evaluate several anatomical hypotheses based on cytoarchitectonics, and to gain a better understanding of the evolution of the forebrain in ray-finned fishes. The subpallium of the telencephalon has the highest concentration of the neuropeptides SP and LENK, allowing the pallial-subpallial border to be easily distinguished. The distribution of dopamine is similar to that of serotonin in the subpallium, fibers positive for these transmitters are particularly dense in the dorsal and ventral divisions of the subpallium. In addition, a small population of DA- and 5HT-positive cell bodies – which appear to be unique to sturgeons – was identified at the level of the anterior commissure. The internal granular layer of the olfactory bulbs had large numbers of TH-positive cell bodies and fibers, as did the rostral subpallium. The occurrence of cell bodies positive for LENK in the dorsal nucleus of the rostral subpallium supports the hypothesis that this nucleus is homologous to the striatum in other vertebrates. This is further reinforced by the apparent origin of an ascending dopaminergic pathway from cells in the posterior tubercle that are likely homologous to the ventral tegmental area/substantia nigra in land vertebrates. Finally, the differential distribution of SP and TH in the pallium supports the hypothesis that the pallium, or area dorsalis, can be divided medially into a rostral division (Dm), a caudal division (Dp) that is the main pallial target of secondary olfactory projections, and a narrow lateral division (Dd+Dl) immediately adjacent to the attachment of the tela choroidea along the entire rostrocaudal length of the telencephalic hemisphere.

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Section: Discussionmentioning

confidence: 99%

Immunohistochemical Organization of the Forebrain in the White Sturgeon, Acipenser transmontanus

Piñuela

Northcutt

2007

Brain Behav Evol

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“…For example, the tendency of insulin to form multimers differs between species (22). NPY-like immunoreactivity has been described in goldfish brain (24), and two NPY-like peptides have been reported to occur in goldfish retina (25). Anglerfish brain contains immunoreactivity distinct from the fish pancreatic peptide PY (26,27) and trout brain displays immunoreactivity with an antiserum to NPY that exhibits no crossreaction with PYY (28).…”

Section: For Review)mentioning

confidence: 99%

Strong evolutionary conservation of neuropeptide Y: sequences of chicken, goldfish, and Torpedo marmorata DNA clones.

Blomqvist

Söderberg²,

Lundell³

et al. 1992

Proc. Natl. Acad. Sci. U.S.A.

178

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Neuropeptide Y (NPY) is an abundant and widespread neuropeptide in the nervous system of mammals. NPY belongs to a family of 36-amino acid peptides that also includes pancreatic polypeptide and the endocrine gut peptide YY as well as the fish pancreatic peptide Y. To study the evolution of this peptide family, we have isolated clones encoding NPY from central nervous system cDNA libraries of chicken, goldfish, and the ray Torpedo marmorata, as well as from a chicken genomic library. The predicted chicken NPY amino acid sequence differs from that of rat at only one position. The goldfish sequence differs at five positions and shows that bony fishes have a true NPY peptide in addition to their pancreatic peptide Y. The Torpedo sequence differs from that of rat at three positions. As Torpedo NPY has no unique positions when compared with the other sequences, it seems to be identical to the NPY of the common ancestor ofcartilaginous fishes, bony fishes, and tetrapods after 420 million years of evolution. The 30-amino acid carboxyl-terminal extension of the NPY precursor also displays considerable sequence conservation. These results show that NPY is one ofthe most highly conserved neuroendocrine peptides.Neuropeptide Y (NPY) was first purified from porcine brain (1). The name is derived from its amino-and carboxylterminal tyrosines (single-letter code Y). Subsequently, NPY sequences have been determined for six other mammals (2) and for a frog (3), revealing a remarkable degree of conservation. NPY occurs abundantly in the mammalian central nervous system as well as in the peripheral nervous system (4) and has been shown to have both pre-and postsynaptic actions (5).NPY belongs to a family of peptides that includes the gut endocrine peptide YY (PYY) and the pancreatic endocrine peptides called pancreatic polypeptide (PP) in tetrapods and peptide tyrosine (PY) in fish. All of these peptides consist of 36 amino acids and have a carboxyl-terminal amide. Porcine NPY and PYY show 70% sequence identity and can act on the same receptors with similar potencies (6), whereas porcine PP is only 50% identical to NPY and PYY and appears to have distinct receptors (7-9). PP differs considerably between species; PP of pig, chicken, and bullfrog share only 44-58% identity.Pancreatic peptides have been isolated and sequenced from four different species of fish (2). Surprisingly, these peptides were found to be more similar to mammalian NPY and PYY than to PP. Because of the unclear relationships with the mammalian peptides, the fish pancreatic peptides have been given different names by different groups of investigators. We use here the designation PY.Immunohistochemical studies of NPY, PYY, and PP have been interpreted to indicate that PP appeared first in evolution (10), and sequence and receptor-binding analyses have suggested that PP forms one evolutionary lineage whereas NPY and PYY form a separate lineage and diverged from each other more recently (11). To extend the structural evolutionary analyses, we decided to isol...

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“…Recently, the presence of kisspeptin 1 and GnRH-II cells was described in the habenula and medial tegmental area of the sea bass, respectively [González-Martínez et al, 2001Zmora et al, 2002;Escobar et al, 2010]; both neuropeptidergic systems are implicated in the processing of environmental and metabolic information . The habenula, dorsal and ventral thalamus, posterior tubercle and mesencephalic tegmentum also contain NPYimmunoreactive neurons in other teleost and non-teleost species [Pontet et al, 1989;Batten et al, 1990;Vecino and Ekström, 1992;García-Fernández et al, 1992;Subhedar et al 1996;Castro et al, 1999;Rodríguez-Gómez et al, 2001;Chiba, 2005]. Interestingly, all these nuclei contain pinealopetal cells in the European sea bass.…”

Section: Pinealopetal Projectionsmentioning

confidence: 99%

Afferent and Efferent Connections of the Pineal Organ in the European Sea Bass Dicentrarchus labrax: A Carbocyanine Dye Tract-Tracing Study

Servili

Herrera-Pérez²,

Yáñez³

et al. 2011

Brain Behav Evol

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The pineal organ of fish is a photosensitive structure that receives light information from the environment and transduces it into hormonal (rhythmic melatonin secretion) and neural (efferent projections/neurotransmitters) signals. In this study, we focused on this neural output. Thus, we performed a tract-tracing study using 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindocarbocyanine perchlorate (DiI), a fluorescent carbocyanine dye, in order to elucidate the efferent and afferent connections of the pineal organ in the European sea bass. The axonal transport of DiI revealed extensive bilateral projections in the sea bass brain. The efferent projections of the sea bass pineal organ reach the habenula, ventral thalamus, periventricular pretectum, central pretectal area, posterior tubercle and medial and dorsal tegmental areas. In addition, in this study we also examined the pinealopetal system in sea bass. This analysis demonstrated that the sea bass pineal organ receives central projections from neurons located, to a large extent, in brain areas innervated by pineal efferent projections, i.e. the thalamic eminence, habenula, ventral thalamus, dorsal thalamus, periventricular pretectum, posterior commissure, posterior tubercle and medial tegmental area. This study is the first description of pinealofugal projections in a representative of Perciformes, which constitutes a derived order within teleosts. Moreover, it represents the first evidence for the presence of pinealopetal neurons in the brain of a teleost species. Our findings, together with the analysis of retinal connections, represent a step forward in the understanding of the integration of photoperiodic signals into the central nervous system of sea bass.

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Distribution and characterization of neuropeptide Y-like immunoreactivity in the brain and pituitary of the goldfish

Cited by 111 publications

References 32 publications

Immunohistochemical Organization of the Forebrain in the White Sturgeon, <i>Acipenser transmontanus</i>

Immunohistochemical Organization of the Forebrain in the White Sturgeon, <i>Acipenser transmontanus</i>

Strong evolutionary conservation of neuropeptide Y: sequences of chicken, goldfish, and Torpedo marmorata DNA clones.

Afferent and Efferent Connections of the Pineal Organ in the European Sea Bass <i>Dicentrarchus labrax:</i> A Carbocyanine Dye Tract-Tracing Study

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