Distribution and diversity of classical deacylases in bacteria
Leonie G. Graf,
Carlos Moreno-Yruela,
Chuan Qin
et al.
Abstract:Classical Zn2+-dependent deac(et)ylases play fundamental regulatory roles in life and are well characterized in eukaryotes regarding their structures, substrates and physiological roles. In bacteria, however, classical deacylases are less well understood. We construct a Generalized Profile (GP) and identify thousands of uncharacterized classical deacylases in bacteria, which are grouped into five clusters. Systematic structural and functional characterization of representative enzymes from each cluster reveal … Show more
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