Distribution and drug resistance of pathogenic bacteria in emergency patients

Huai, Wei; Ma, Qingbian; Zheng, Jiajia; Zhao, Yang; Zhai, Qiangrong

doi:10.12998/wjcc.v7.i20.3175

Cited by 18 publications

(18 citation statements)

References 29 publications

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“…Therefore, widespread screen of antibiotics is required for identification of the most effective drug in the synergistic use with the crucial biomarker. More importantly, both SCF-resistant and amikacin-resistant P. aeruginosa is a big challenge to uncontrolled infection in clinic ( Huai et al, 2019 ). Amikacin is one of antibiotics for the treatment of P. aeruginosa with difficult-to-treat resistance infections ( Tamma et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

“…The frequency of P. aeruginosa isolates resistant to agents recommended for the treatment of hospital-acquired pneumonia ranged 22.2% for amikacin to 50.0% for cefoperazone ( Ding et al, 2016 ). Another investigation in emergency patients from 2013 to 2017 shows higher resistance rates of P. aeruginosa to cefoperazone/sulbactam (SCF) with the resistance increasing year over year, while the resistance rate to amikacin was below 10% ( Huai et al, 2019 ). These investigations suggest that SCF-resistant P. aeruginosa is a great challenge to be controlled and amikacin can be a suitable drug for combatting multidrug-resistant P. aeruginosa .…”

Section: Introductionmentioning

confidence: 99%

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Glucose-Potentiated Amikacin Killing of Cefoperazone/Sulbactam Resistant Pseudomonas aeruginosa

Tang

et al. 2022

Front. Microbiol.

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Multidrug-resistant Pseudomonas aeruginosa has become one of global threat pathogens for human health due to insensitivity to antibiotics. Recently developed reprogramming metabolomics can identify biomarkers, and then, the biomarkers were used to revert the insensitivity and elevate antibiotic-mediated killing. Here, the methodology was used to study cefoperazone/sulbactam (SCF)-resistant P. aeruginosa (PA-RSCF) and identified reduced glycolysis and pyruvate cycle, a recent clarified cycle providing respiratory energy in bacteria, as the most key enriched pathways and the depressed glucose as one of the most crucial biomarkers. Further experiments showed that the depression of glucose was attributed to reduction of glucose transport. However, exogenous glucose reverted the reduction to elevate intracellular glucose via activating glucose transport. The elevated glucose fluxed to the glycolysis, pyruvate cycle, and electron transport chain to promote downstream proton motive force (PMF). Consistently, exogenous glucose did not promote SCF-mediated elimination but potentiated aminoglycosides-mediated killing since aminoglycosides uptake is PMF-dependent, where amikacin was the best one. The glucose-potentiated amikacin-mediated killing was effective to both lab-evolved PA-RSCF and clinical multidrug-resistant P. aeruginosa. These results reveal the depressed glucose uptake causes the reduced intracellular glucose and expand the application of metabolome-reprogramming on selecting conventional antibiotics to achieve the best killing efficacy.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Glucose-Potentiated Amikacin Killing of Cefoperazone/Sulbactam Resistant Pseudomonas aeruginosa

Tang

et al. 2022

Front. Microbiol.

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“…Moreover, 19 of them had multiple Klebsiella pneumoniae infections, while 13 patients had a history of reinfections with various pathogens. Moreover, attention should be paid to the antibiotic resistance of Klebsiella pneumoniae and the antibiotic should be adjusted in time[ 26 ]. We did not analyze the etiology distribution or costs among all the patients due to a lack of research, which is a deficiency of this review.…”

Section: Discussionmentioning

confidence: 99%

Klebsiella pneumoniae infection secondary to spontaneous renal rupture that presents only as fever: A case report

Zhang

Duan

Zhang

et al. 2021

WJCC

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BACKGROUND Spontaneous renal rupture is a rare disease in the clinic. The causes of spontaneous renal rupture include extrarenal factors, intrarenal factors, and idiopathic factors. Reports on infection secondary to spontaneous renal rupture and the complications of spontaneous renal rupture are scarce. Furthermore, there are few patients with spontaneous renal rupture who present only with fever. CASE SUMMARY We present the case of a 52-year-old female patient who was admitted to our hospital. She presented only with fever, and the cause of the disease was unclear. She underwent a contrast-enhanced computed tomography (CT) scan, which showed that the left renal capsule had a crescent-shaped, low-density shadow; the perirenal fat was blurred, and exudation was visible with no sign of calculi, malignancies, instrumentation, or trauma. Under ultrasound guidance, a pigtail catheter was inserted into the hematoma, and fluid was drained and used for the bacterial test, which proved the presence of Klebsiella pneumoniae. Two months later, abdominal CT showed that the hematoma was absorbed, so the drainage tube was removed. The abdominal CT was normal after 4 mo. CONCLUSION Spontaneous renal rupture due to intrarenal factors causes a higher proportion of shock and is more likely to cause anemia.

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“…to β-lactam antibiotics including carbapenem is rife. Huai et al [19] reported Klebsiella pneumoniae isolates that had high rate of resistance to impenem in China. Similarly, Yazdansetad et al [20] a 50% rate of extended spectrum β-lactamase (ESBL) producing K. pneumoniae in Iran.…”

Section: Discussionmentioning

confidence: 99%

Efflux pump activity, biofilm formation and antibiotic resistance profile of Klebsiella spp. isolated from clinical samples at Lagos University Teaching Hospital

et al. 2020

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Objective: Nosocomial and community acquired multidrug resistant Klebsiella infections are wide spread resulting in high morbidity and mortality due to limited number of antibiotics treatment options. This study investigated efflux pump activity, biofilm forming potential and antibiotic susceptibility profile of Klebsiella spp. isolated from clinical samples in a tertiary hospital in Lagos Nigeria. Eighteen clinical Klebsiella spp. isolated from urine, blood and sputum were subjected to antibiotic susceptibility testing using the disc diffusion method. Efflux pump activity was evaluated by the ethidium bromide cartwheel method and biofilm forming ability was determined by the tissue culture plate technique. Results: All 18 (100%) Klebsiella isolates were resistant to cefuroxime, cefixime, amoxicillin − clavulanate, ampicillin + cloxacillin, cefotaxime, and imipenem. Seventeen (94.4%) were resistant to ofloxacin while sixteen (88.9%) were resistance to nalidixic acid, Gentamicin and levofloxacin. All Klebsiella isolates possessed active efflux pump with the ability to form biofilm. However, their biofilm forming capabilities varied as 4 (22.2%) were strong, 3 (16.7%) were moderate and 11 (61.1%) were weak biofilm formers. Findings in this study reveal multiple factors at play in mediating the high level of antibiotic resistance observed in Klebsiella isolates. Hence a multifaceted approach is advocated in managing the infections caused by the pathogen.

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Distribution and drug resistance of pathogenic bacteria in emergency patients

Cited by 18 publications

References 29 publications

Glucose-Potentiated Amikacin Killing of Cefoperazone/Sulbactam Resistant Pseudomonas aeruginosa

Glucose-Potentiated Amikacin Killing of Cefoperazone/Sulbactam Resistant Pseudomonas aeruginosa

Klebsiella pneumoniae infection secondary to spontaneous renal rupture that presents only as fever: A case report

Efflux pump activity, biofilm formation and antibiotic resistance profile of Klebsiella spp. isolated from clinical samples at Lagos University Teaching Hospital

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