Distribution and Elimination of Polymethyl Methacrylate Nanoparticles After Peroral Administration to Rats

Nefzger, M.; Kreuter, Jörg; Voges, Rolf; Liehl, E.; Czok, R.

doi:10.1002/jps.2600730934

Cited by 52 publications

(8 citation statements)

References 6 publications

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“…5) exceeding the renal excretion threshold (28) and the fact that the majority of nanotubes accumulates in the liver, we suggest that urinary excretion occurs for a small percentage of nanotubes with very short length (Ͻ50 nm in length, diameter 1-2 nm) in our sample at early time points after injection. Because of the existence of nanotubes in feces, the nonbiodegradable nature of sp 2 carbon SWNT structure and the fact that foreign nondegradable substances (including various nanoparticles) in the liver are known to be excreted through the biliary pathway from the liver to the bile duct, intestine, and feces (29)(30)(31)(32)(33)(34)(35), we propose that excretion of our SWNTs from mice occurs over time mainly via the biliary pathway and ends up in feces.…”

Section: Resultsmentioning

confidence: 99%

Circulation and long-term fate of functionalized, biocompatible single-walled carbon nanotubes in mice probed by Raman spectroscopy

Liu

Davis

Cai

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

1,047

879

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Carbon nanotubes are promising new materials for molecular delivery in biological systems. The long-term fate of nanotubes intravenously injected into animals in vivo is currently unknown, an issue critical to potential clinical applications of these materials. Here, using the intrinsic Raman spectroscopic signatures of singlewalled carbon nanotubes (SWNTs), we measured the blood circulation of intravenously injected SWNTs and detect SWNTs in various organs and tissues of mice ex vivo over a period of three months. Functionalization of SWNTs by branched polyethyleneglycol (PEG) chains was developed, enabling thus far the longest SWNT blood circulation up to 1 day, relatively low uptake in the reticuloendothelial system (RES), and near-complete clearance from the main organs in Ϸ2 months. Raman spectroscopy detected SWNT in the intestine, feces, kidney, and bladder of mice, suggesting excretion and clearance of SWNTs from mice via the biliary and renal pathways. No toxic side effect of SWNTs to mice was observed in necropsy, histology, and blood chemistry measurements. These findings pave the way to future biomedical applications of carbon nanotubes.biodistribution ͉ blood circulation ͉ nanoparticles ͉ excretion ͉ toxicity T he utilization of novel nanomaterials for biological and biomedical applications has been an active and exciting direction of research in recent years (1-3). A wide range of nanomaterials, such as nanoparticles (4 -7), nanorods (8), nanowires (9), and nanotubes (10-12) have been investigated for their potential clinical applications in diagnosis and therapeutic treatment of diseases. The interesting structural, chemical, electrical, and optical properties of carbon nanotubes (13,14), when used in biological and medical settings, may bring new opportunities to biological detection, imaging, and therapy with high performance and efficacy. Carbon nanotube-based intercellular molecular delivery vehicles have been developed for intracellular gene (15-17) and drug delivery in vitro (18,19). Recently, research began to investigate the behavior of carbon nanotubes in animal bodies in vivo (20,21), including the finding of lack of toxicity of well PEGylated single-walled carbon nanotubes (SWNTs) in mice in a pilot study (M. L. Schipper, N. NakayamaRatchford, C.D., N. W. S. Kam, P. Chu, Z.L., X. Sun, L. C. Cork, H.D., and S. S. Gambhir, unpublished data).The biodistribution of intravenously injected carbon nanotubes in mice has been studied by using radiolabeling and isotope ratio mass spectroscopy methods (20,22). Promising result of efficient targeted tumor accumulation in vivo has been obtained by conjugating a ligand peptide to nanotubes to recognize receptors on the surface of tumor cells (20), suggesting high potential of nanotube-based drug delivery vehicles for cancer therapy. However, an important unaddressed question for carbon nanotubes and various nanomaterials in general in biomedical applications is their long term fate in vivo. It is known that most nanomaterials tend to exhibit high upt...

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Section: Resultsmentioning

confidence: 99%

Circulation and long-term fate of functionalized, biocompatible single-walled carbon nanotubes in mice probed by Raman spectroscopy

Liu

Davis

Cai

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

1,047

879

View full text Add to dashboard Cite

show abstract

“…This could be directly inferred from the hereby exposed viewpoint that witnesses the emergence of nanoscience and its applicative findings from the puzzling peculiarities observed at the nanoscale. For example, some time after it had been found out that nanoparticles have a tendency to accumulate in the lymph nodes, 41 this effect began to be utilized in preparation of nanoparticle formulations for targeting lymph node dendritic cells and delivering adjuvants, suspensions of antibodies used to boost immune response, thereto. 42,43 Therefore, just as shelled mollusks form calcium carbonate pearls as a response to irritating particles of sand and just as binocular creatures turn the binocular disparity from the cause of disorienting double vision to the source of stereoscopic vision, so could we expect the future to bring many instances of transformation of the harmful and perplexing into the remedial and enlightening in the domain of nanoscience.…”

Section: Crossing the Gap Between Life Science And Materials Sciencementioning

confidence: 99%

Entering the Era of Nanoscience: Time to Be So Small Vuk Uskokovíc

Uskoković¹

2013

Journal of Biomedical Nanotechnology

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The field of nanoscience has produced more hype than probably any other branch of materials science and engineering in its history. Still, the potentials of this new field largely lay undiscovered ahead of us; what we have learnt so far with respect to the peculiarity of physical processes on the nanoscale is only the tip of an iceberg. Elaborated in this critical review is the idea that the surge of interest in physical chemistry of phenomena at the nanoscale presents a natural consequence of the spatial refinement of the human ability to controllably manipulate the substratum of our physical reality. Examples are given to illustrate the sensitivity of material properties to grain size on the nanoscale, a phenomenon that directly contributed to the rise of nanoscience as a special field of scientific inquiry. Main systemic challenges faced by the present and future scientists in this field are also mentioned. In part, this perspective article resembles standing on the constantly expanding seashore of the coast of nanoscience and nanoengineering and envisioning the parts of the island where the most significant advances may be expected to occur and where, therefore, most of the attention of scientist in this field is to be directed: (a) crossing the gap between life science and materials science; (b) increasing experimentation sensitivity; (c) crisscrossing theory and experiments; and (d) conjoining top-down and bottom-up synthetic approaches. As for materials and the application areas discussed, a special emphasis is placed on calcium phosphate nanoparticles and their usage in controlled drug delivery devices and other applications of biomedical relevance. It is argued that the properties of nanoparticles as drug carriers often comprise the critical determinant for the efficacy of the drug therapy. Therefore, the basic properties of nanoparticles to be optimized for the purpose of maximizing this efficacy are discussed: size, size distribution, morphology, polymorphic nature, crystallinity, biocompatibility, biodegradability, drug elution profiles, and aggregation propensity.

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“…However, the distribution of NPs after oral ingestion differs according to the model used and the NPs. After intestinal absorption, some NPs are excreted in the faeces and urine (Furchner et al 1968;Nefzger et al 1984) and others enter the portal circulation and the liver or lymphatic system. Loeschner et al (2011) and Van der Zande et al (2012) showed fecal excretion and Park et al (2011) detected silver in rat urine and faeces following the ingestion of 1 mg/kg BW of 8 nm AGNPs.…”

Section: Toxicity and Toxicocinetics Of Agnps After Oral Intakementioning

confidence: 99%

Silver nanoparticles: Their potential toxic effects after oral exposure and underlying mechanisms – A review

Gaillet

Rouanet

2015

Food and Chemical Toxicology

256

138

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Distribution and Elimination of Polymethyl Methacrylate Nanoparticles After Peroral Administration to Rats

Cited by 52 publications

References 6 publications

Circulation and long-term fate of functionalized, biocompatible single-walled carbon nanotubes in mice probed by Raman spectroscopy

Circulation and long-term fate of functionalized, biocompatible single-walled carbon nanotubes in mice probed by Raman spectroscopy

Entering the Era of Nanoscience: Time to Be So Small Vuk Uskokovíc

Silver nanoparticles: Their potential toxic effects after oral exposure and underlying mechanisms – A review

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