Distribution and Excretion of Radiofluoride in the Human.

Carlson, Claire; Armstrong, W. D.; Singer, Leon

doi:10.3181/00379727-104-25791

Cited by 98 publications

(28 citation statements)

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“…The model of subtotal nephrectomy is characterized by an augmented single-nephron glomerular filtration rate, and adaptive in crease in the excretion of water and solute by the individual residual nephrons [I I], by normal plasma bicarbonate con centration and similar tubular bicarbonate reabsorption expressed as mEq/l GFR [2], similar urine pH [9] as well as expansion of the extracellular volume [2]. Several in vestigators have demonstrated in man [5,8] and experi mental animals [4,6,25] that the clearance of fluoride shows a positive correlation to the urine flow rate. In accordance to these reports, the present study shows a highly significant relationship between fractional fluoride clearance and urine flow rate in nephrectomized and kid ney-intact, hydropenic animals.…”

Section: Discussionmentioning

confidence: 99%

“…Despite the 'black box' approach implicit in clearance studies, a critical concept of tubular fluoride transport arose from these studies. Classical clearance techniques in man [3,5,13] and experimental animals [4.6.25] have shown that over wide variations of plasma fluoride levels, the fluoride clear ance is substantially less than the glomerular filtration rate. Thisindicatesthat the predominant renal mechanisms reg ulating fluoride excretion are filtration and net tubular reabsorption.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Renal Fluoride Excretion: Experimental Evaluation of the Role of Extracellular Volume Status during Intact and Impaired Kidney Function

Schiffl¹,

Hofmann²,

Huggler³

et al. 1981

Nephron

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The renal clearance of inorganic fluoride was studied in 5/6-nephrectomized and kidney-intact rats in order to evaluate the influence of the extracellular fluid volume status on net tubular fluoride reabsorption. Loss of renal functional mass impaired the ability of the hydropenic uremic rat to excrete fluoride, although tubular reabsorption of fluoride was depressed. Fractional fluoride excretion was closely correlated to urinary flow rate in hydropenic rats; no influence of urinary pH from 5.80 to 6.18 could be demonstrated. Acute, moderate expansion of the extracellular fluid volume by isotonic saline was followed by a significant rise in fractional fluoride excretion in uremic as well as in control rats, indicating that extracellular fluid volume is an important physiological determinant of passive tubular fluoride reabsorption.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Renal Fluoride Excretion: Experimental Evaluation of the Role of Extracellular Volume Status during Intact and Impaired Kidney Function

Schiffl¹,

Hofmann²,

Huggler³

et al. 1981

Nephron

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show abstract

“…Renal F excretion involves glomerular filtration fol lowed by variable tubular reabsorption [4,6,8,11,14,19,25,26]. The binding of F to plasma proteins or macro molecules is negligible [10,15].…”

Section: Discussionmentioning

confidence: 99%

Human Urinary Fluoride Excretion as Influenced by Renal Functional Impairment

Schiffl

Binswanger²

1980

Nephron

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The effects of renal function on human renal fluoride (F-) excretion and serum F_- concentrations were studied in subjects with normal renal function, in patients with variable degrees of renal insufficiency and in patients undergoing regular hemodialysis treatment. The mechanisms of human renal F- excretion include glomerular filtration and tubular reabsorption. Patients suffering from chronic renal disease tend to continue to excrete normal dietary loads of F- until the creatinine clearance decreases below 25 ml/min. In chronic renal failure elevation of the serum fluoride concentration is delayed and less than might be expected from impairment of the glomerular filtration rate, because tubular reabsorption diminishes presumably due to expansion of the extracellular fluid compartiment.

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“…Oxidative damage of nuclear and mitochondrial DNA in human brain is supposedly involved in mild cognitive impairments that establish relevance of integrity of brain DNA to brain function [9]. It is further suggested from the earlier studies that fluoride mostly affects soft tissues including brain [10] due to easy permeability across the cell membrane [11] as well as due to presence of more unsaturated fatty acids, high oxygen utilization, high iron content and decreased activities of detoxifying enzymes in that tissue [12].…”

Section: Introductionmentioning

confidence: 99%

Tissue specific differential response in metabolic activities of cerebrum, cerebellum, pons and medulla associated with thyroid dysfunction in sub-acute fluoride toxicity

Sarkar

Pal

2015

Int Jour of Biomed Res

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Objectives: In this present in vivo study, it is intended to examine the effects of fluoride on metabolic functions of four discrete regions of rat brain associated with thyroidal insufficiency. Background: Fluoride contamination in drinking water is a major health issue. Adverse health effects of fluoride include dental and muscle fluorosis, lowering mental proficiency, neurological disorders and oxidative stress in soft tissues including brain. Thyroid is mainly concerned with regulation of metabolic homeostasis and thus supposed to be altered by fluoride toxicity. Rationale: Earlier observations indicate that fluoride toxicity imposes certain adverse effects on brain metabolic activities. Alteration in metabolic profile in brain may be affected by the thyroid gland as because this gland takes care of the overall metabolic integration of the body. Significance: The present study explores the detail mechanism of metabolic alteration of different parts of rat brain namely cerebrum, cerebellum, pons and medulla by fluoride, and also evaluates through a comparative analysis that which region is mostly affected by it. Furthermore, this study also suggests a link between brain metabolic profile and thyroid function. Methods: Male rats of Wistar strain (N=6) were orally fed with 20 mg/kg/day fluoride for 30 days. Results: Following fluoride exposure, total protein content depleted more significantly in cerebrum and medulla as compared with other brain regions. The proleolytic enzyme activity was severely affected by fluoride, especially in medulla. Changes in acidic, basic and neutral protein contents reveal that fluoride altered those parameters in a tissue specific manner. Nucleic acid contents were markedly reduced in medulla and pons by fluoride, whereas RNase activity increased in the respective brain regions. Protein carbonylation is pronounced in cerebral tissue. The neurotransmitter level was markedly reduced in cerebellum in comparison with others. Additionally, fluoride also altered thyroid metabolism as specified by depletion of nucleic acid contents and inhibition of the activities of thyroidal enzymes along with significant decrease in serum T3 and T4. Conclusion: It is suggested that fluoride altered metabolic homeostasis in cerebrum, cerebellum, pons, medulla in a tissue specific manner that might be correlated with thyroidal insufficiency.

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Distribution and Excretion of Radiofluoride in the Human.

Cited by 98 publications

References 0 publications

Renal Fluoride Excretion: Experimental Evaluation of the Role of Extracellular Volume Status during Intact and Impaired Kidney Function

Renal Fluoride Excretion: Experimental Evaluation of the Role of Extracellular Volume Status during Intact and Impaired Kidney Function

Human Urinary Fluoride Excretion as Influenced by Renal Functional Impairment

Tissue specific differential response in metabolic activities of cerebrum, cerebellum, pons and medulla associated with thyroid dysfunction in sub-acute fluoride toxicity

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