Distribution and Genotoxic Effects After Successive Exposure to Different Uranium Oxide Particles Inhaled by Rats

Monleau, Marjorie; Méo, Michel De; Frelon, Sandrine; Paquet, F.; Donnadieu-Claraz, M.; Duménil, Gérard; Chazel, V.

doi:10.1080/08958370600822524

Cited by 26 publications

(13 citation statements)

References 36 publications

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“…Inhalation studies in vivo have also demonstrated that inhaled DU is genotoxic (Monleau et al 2006), inhibits vitamin metabolism (Tissandie et al 2006), accumulates in brain (Houpert et al 2007), and adversely affects rodent behavior (Monleau et al 2005). The Capstone DU Aerosol Study was conducted to characterize aerosols generated from DU munitions fired into combat vehicles Hahn et al 2009).…”

Section: Introductionmentioning

confidence: 99%

Preconceptional Paternal Exposure to Depleted Uranium: Transmission of Genetic Damage to Offspring

Miller

Stewart²,

Rivas³

2010

Health Physics

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Depleted uranium (DU) is an alpha particle emitter and radioactive heavy metal used in military applications. Due to internalization of DU during military operations and the ensuing chronic internal exposure to DU, there are concerns regarding its potential health effects. Preconceptional paternal irradiation has been implicated as a causal factor in childhood cancer and it has been suggested that this paternal exposure to radiation may play a role in the occurrence of leukemia and other cancers to offspring. Similarly, in vivo heavy metal studies have demonstrated that carcinogenic effects can occur in unexposed offspring. Using a transgenic mouse system employing a lambda shuttle vector allowing mutations (in the lacI gene) to be analyzed in vitro, we have investigated the possibility that chronic preconceptional paternal DU exposure can lead to transgenerational transmission of genomic instability. The mutation frequencies in vector recovered from the bone marrow cells of the F1 offspring of male parents exposed to low, medium, and high doses of internalized DU for 7 mo were evaluated and compared to control, tantalum, nickel, and gamma radiation F1 samples. Results demonstrate that as paternal DU-dose increased there was a trend towards higher mutation frequency in vector recovered from the DNA obtained from bone marrow of F1 progeny; medium and high dose DU exposure to P1 fathers resulted in a significant increase in mutation frequency in F1 offspring (3.57 +or - 0.37 and 4.81 + or - 0.43 x 10; p < 0.001) in comparison to control (2.28 + or - 0.31 x 10). The mutation frequencies from F1 offspring of low dose DU, Ta- or Ni-implanted fathers (2. 71 + or - 0.35, 2.38 + or - 0.35, and 2.93 + or - 0.39 x 10, respectively) were not significantly different than control levels (2.28 + or - 0.31 x 10). Offspring from Co (4 Gy) irradiated fathers did demonstrate an increased lacI mutation frequency (4.69 + or - 0.48 x 10) as had been shown previously. To evaluate the role of radiation involved in the observed DU effects, males were exposed to equal concentrations (50 mg U L) of either enriched uranium or DU in their drinking water for 2 mo prior to breeding. A comparison of these offspring indicated that there was a specific-activity dependent increase in offspring bone marrow mutation frequency. Taken together these uranyl nitrate data support earlier results in other model systems showing that radiation can play a role in DU-induced biological effects in vitro. However, since the lacI mutation model measures point mutations and cannot measure large deletions that are characteristic of radiation damage, the role of DU chemical effects in the observed offspring mutation frequency increase may also be significant. Regardless of the question of DU-radiation vs. DU-chemical effects, the data indicate that there exists a route for transgenerational transmission of factor(s) leading to genomic instability in F1 progeny from DU-exposed fathers.

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Section: Introductionmentioning

confidence: 99%

Preconceptional Paternal Exposure to Depleted Uranium: Transmission of Genetic Damage to Offspring

Miller

Stewart²,

Rivas³

2010

Health Physics

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“…Particle genotoxicity can be caused by direct actions or by indirect mechanisms often mediated by reactive oxygen species (ROS) produced mainly by the inflammatory cells (Kirsch-Volders et al, 2003;Martin et al, 1997). In agreement with these observations, Monleau et al, (2006), demonstrated DNA strand breaks in lung rats after DU acute and chronic exposure by inhalation, was a consequence of oxidative stress and induction of pro inflammatory IL8 and TNFα gene expression. These effects seemed to be linked to the DU doses and independent of the solubility of uranium compound.…”

Section: The Respiratory Systemmentioning

confidence: 64%

“…Induction of diverse inflammatory reactions was also reported following uranium contamination in different tissues. For instance, activation of cytokine expression and/or production was noted either in pulmonary tissues following uranium exposure by inhalation (Monleau et al, 2006) or in macrophages after in vitro contamination (Gazin et al, 2004;Wan et al, 2006)…”

Section: Inhalation Routementioning

confidence: 99%

Cell Metabolism - Cell Homeostasis and Stress Response

Bubulya¹

2012

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“…Particle genotoxicity can be caused by direct actions or by indirect mechanisms often mediated by reactive oxygen species (ROS) produced mainly by the inflammatory cells (Kirsch-Volders et al, 2003;Martin et al, 1997). In agreement with these observations, Monleau et al, (2006), demonstrated DNA strand breaks in lung rats after DU acute and chronic exposure by inhalation, was a consequence of oxidative stress and induction of pro inflammatory IL8 and TNF gene expression. These effects seemed to be linked to the DU doses and independent of the solubility of uranium compound.…”

Section: The Respiratory Systemmentioning

confidence: 64%

Intracellular Metabolism of Uranium and the Effects of Bisphosphonates on Its Toxicity

Tasat¹,

Orona²,

Bozal³

et al. 2012

Cell Metabolism - Cell Homeostasis and Stress Response

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Distribution and Genotoxic Effects After Successive Exposure to Different Uranium Oxide Particles Inhaled by Rats

Cited by 26 publications

References 36 publications

Preconceptional Paternal Exposure to Depleted Uranium: Transmission of Genetic Damage to Offspring

Preconceptional Paternal Exposure to Depleted Uranium: Transmission of Genetic Damage to Offspring

Cell Metabolism - Cell Homeostasis and Stress Response

Intracellular Metabolism of Uranium and the Effects of Bisphosphonates on Its Toxicity

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