Distribution and genotype frequency of adiponectin (+45 T/G) and adiponectin receptor2 (+795 G/A) single nucleotide polymorphisms in Iranian population

Namvaran, Fatemeh; Azarpira, Negar; Geramizadeh, Bita; Rahimi‐Moghaddam, Parvaneh

doi:10.1016/j.gene.2011.07.009

Cited by 11 publications

(6 citation statements)

References 38 publications

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“…The results of previous studies show ethnic variations in allelic and genotypic frequencies of SNP +45 T > G in the adiponectin gene [ 20 ]. In this study, the frequency of TG/GG genotype and G allele among the non-GDM subjects was approximately 23% and 11%, respectively which is in line with Namvaran, et al’s findings [ 27 ]. The frequency of the rare G allele observed in the control group of this study is similar to that reported for the healthy subjects in some other populations [see for review 31] but it is lower than that reported for the healthy Chinese and Korean subjects (30% and 20%, respectively) [ 28 , 29 ].…”

Section: Discussionsupporting

confidence: 91%

The association of circulating adiponectin and + 45 T/G polymorphism of adiponectin gene with gestational diabetes mellitus in Iranian population

Takhshid

Haem

Aboualizadeh

2015

J Diabetes Metab Disord

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BackgroundAdiponectin is an adipokine with insulin-sensitizing effects. We investigated the relationship between the single nucleotide polymorphism (SNP) +45 T > G ( rs 2241766 ;Gly15Gly) in the adiponectin gene, serum adiponectin levels, insulin resistance and risk of gestational diabetes (GDM) in Iranian population.Methods65 GDM patients and 70 healthy pregnant women were enrolled in this study. Genotyping for SNP +45 T > G in the adiponectin gene ( rs 2241766 ) was performed by the polymerase chain reaction-restriction fragment length polymorphism method. The level of fasting serum adiponectin, insulin, glucose, and lipid levels were measured. Insulin resistance was estimated using homeostasis model of assessment for insulin resistance (HOMA-IR).ResultsThe G allele and TG/GG genotype of rs 2241766 were more frequent than the T allele and TT genotype in GDM patients compared to the controls (p < 0.05). Multiple logistic regression analysis revealed that the risk of GDM was significantly higher in subjects with the TG/GG genotype to those with TT genotype [odds ratio = 2.38, 95% CI 1.09-5.22, p = 0.030]. No significant association was observed between genotypes of rs 2241766 and circulating concentrations of adiponectin. Multiple regression analysis showed that serum adiponectin levels was negatively associated with HOMA-IR in GDM patients (β = −0.385, p <0.01).ConclusionThe findings demonstrated that TG/GG genotype of rs 2241766 was an independent risk factor of GDM in our population. Furthermore, circulating adiponectin level was negatively correlated with insulin resistance in GDM patients.

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Section: Discussionsupporting

confidence: 91%

The association of circulating adiponectin and + 45 T/G polymorphism of adiponectin gene with gestational diabetes mellitus in Iranian population

Takhshid

Haem

Aboualizadeh

2015

J Diabetes Metab Disord

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“…Admixture of the Brazilian population does not allow adequate classification by ethnic group; this condition may limit the comparisons of our findings with the same polymorphisms studied in other populations. Despite the heterogeneity of our population, the frequencies of the variant alleles did not markedly differ from data previously reported in literature [39-41]. …”

Section: Discussioncontrasting

confidence: 50%

Associations of the TNF-alpha -308 G/A, IL6 -174 G/C and AdipoQ 45 T/G polymorphisms with inflammatory and metabolic responses to lifestyle intervention in Brazilians at high cardiometabolic risk

Curti

Pires

Barros

et al. 2012

Diabetol Metab Syndr

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BackgroundCytokines secreted by the adipose tissue influence inflammation and insulin sensitivity, and lead to metabolic disturbances. How certain single-nucleotide polymorphisms (SNPs) interfere on lifestyle interventions is unclear. We assessed associations of selected SNPs with changes induced by a lifestyle intervention.MethodsThis 9-month intervention on diet and physical activity included 180 Brazilians at high cardiometabolic risk, genotyped for the TNF-α -308 G/A, IL-6 -174 G/C and AdipoQ 45 T/G SNPs. Changes in metabolic and inflammatory variables were analyzed according to these SNPs. Individuals with at least one variant allele were grouped and compared with those with the reference genotype.ResultsIn the entire sample (66.7% women; mean age 56.5 ± 11.6 years), intervention resulted in lower energy intake, higher physical activity, and improvement in anthropometry, plasma glucose, HOMA-IR, lipid profile and inflammatory markers, except for IL-6 concentrations. After intervention, only variant allele carriers of the TNF-α -308 G/A decreased plasma glucose, after adjusting for age and gender (OR 2.96, p = 0.025). Regarding the IL6 -174 G/C SNP, carriers of the variant allele had a better response of lipid profile and adiponectin concentration, but only the reference genotype group decreased plasma glucose. In contrast to individuals with the reference genotype, carriers of variant allele of AdipoQ 45 T/G SNP did not change plasma glucose, apolipoprotein B, HDL-c and adiponectin concentrations in response to intervention.ConclusionThe TNFα -308 G/A SNP may predispose a better response of glucose metabolism to lifestyle intervention. The IL-6 -174 G/C SNP may confer a beneficial effect on lipid but not on glucose metabolism. Our findings reinforce unfavorable effects of the AdipoQ 45 T/G SNP in lipid profile and glucose metabolism after intervention in Brazilians at cardiometabolic risk. Further studies are needed to direct lifestyle intervention to subsets of individuals at cardiometabolic risk.

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“…In our study the frequencies of genotypes did not markedly differ from data previously reported in the literature (18)(19)(20). Contrasting with numerous reports on the frequencies of -308 G/A SNP and association with body adiposity and metabolic disturb- Table I.…”

Section: Discussioncontrasting

confidence: 74%

Asociación del polimorfi smo TNF-alpha -308 G/A con los cambios metabólicos secundarios a una dieta hipocalórica rica en proteínas/baja en hidratos de carbono versus una dieta hipocalórica estándar

et al. 2016

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Palabras clave:Polimorfi smo G308 TNF-alpha. Dieta hipocalórica. Obesidad. ResumenAntecedentes: los diferentes estudios genéticos han identifi cado un cambio G-> A en la región promotora del gen de TNF-alfa en la posición -308 (rs1800629). Objetivo: el objetivo de nuestro estudio fue investigar la infl uencia del polimorfi smo en -308 GA del gen TNF-alfa en la respuesta metabólica y la pérdida de peso secundarias a dos dietas hipocalóricas. Método: una muestra de 283 sujetos obesos fue evaluada en forma prospectiva consecutiva. En la visita basal, los pacientes fueron asignados al azar durante 9 meses a una dieta HP (dieta de alto valor proteico/baja en hidratos de carbono) y dieta S (dieta hipocalórica estándar). Resultados: no hubo diferencias signifi cativas entre los efectos positivos sobre la pérdida de peso entre los grupos genotipo con ambas dietas. Con ambas dietas y solo en el genotipo salvaje (dieta HP vs. dieta S), el colesterol total (-9,1 ± 3,4 mg/dl vs. -6,9 ± 2,0 mg/dl; p > 0,05), colesterol LDL (-9,0 ± 2,9 mg/dl vs. -6,5 ± 2,1 mg/dl; p > 0,05) y los triglicéridos (-23,1 ± 5,1 mg/dl vs. -12,3 ± 4,8 mg/dl; p < 0,05) disminuyeron signifi cativamente. La mejora de los triglicéridos fue mayor en sujetos sin el alelo A. Con la dieta HP y solo en el genotipo salvaje, los niveles de insulina (-3,1 ± 1,8 UI/l; p < 0,05) y HOMA-R (-0,8 ± 0,1 unidades; p < 0,05) disminuyeron. Conclusión: los obesos portadores de la variante -308 GG del gen TNF tienen una mejor respuesta metabólica que los sujetos con genotipo -308 GA con una dieta hipocalórica rica en proteínas. AbstractBackground: Mutation analysis has identifi ed a G-> A transition in the promoter region of TNF-alpha gene at position -308 (rs1800629). Objective: The aim of our study was to investigate the infl uence of polymorphism in -308 GA promoter variant of the TNF alpha gene on metabolic response and weight loss secondary to two hypocaloric diets. Method: A sample of 283 obese subjects was enrolled in a consecutive prospective way. In the basal visit, patients were randomly allocated during 9 months to diet HP (high protein/low carbohydrate hypocaloric diet) and diet S (standard hypocaloric diet). Results: There were no signifi cant differences between the positive effects on weight loss in either genotype group with both diets. With both diets and only in wild genotype (diet HP vs. diet S), total cholesterol (-9.1 ± 3.4 mg/dL vs. -6.9 ± 2.0 mg/dL; p > 0.05), LDL cholesterol (-9.0 ± 2.9 mg/dL vs. -6.5 ± 2.1 mg/dL; p > 0.05) and triglycerides (-23.1 ± 5.1 mg/dL vs. -12.3 ± 4.8 mg/dL; p < 0.05) decreased. The improvement in triglycerides was higher in subjects without A allele. With diet HP and only in wild genotype, insulin levels (-3.1 ± 1.8 UI/L; p < 0.05) and HOMA-R (-0.8 ± 0.1 units; p < 0.05) decreased. Conclusion: Carriers of -308 GG promoter variant of TNF-alpha gene have a better metabolic response than -308 GA obese with a high protein hypocaloric diet.

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Distribution and genotype frequency of adiponectin (+45 T/G) and adiponectin receptor2 (+795 G/A) single nucleotide polymorphisms in Iranian population

Cited by 11 publications

References 38 publications

The association of circulating adiponectin and + 45 T/G polymorphism of adiponectin gene with gestational diabetes mellitus in Iranian population

The association of circulating adiponectin and + 45 T/G polymorphism of adiponectin gene with gestational diabetes mellitus in Iranian population

Associations of the TNF-alpha -308 G/A, IL6 -174 G/C and AdipoQ 45 T/G polymorphisms with inflammatory and metabolic responses to lifestyle intervention in Brazilians at high cardiometabolic risk

Asociación del polimorfi smo TNF-alpha -308 G/A con los cambios metabólicos secundarios a una dieta hipocalórica rica en proteínas/baja en hidratos de carbono versus una dieta hipocalórica estándar

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