Distribution and metabolism of disodium cromoglycate in rats

Moss, Gerald; Jones, Kristen M.; Ritchie, Jean T.; Cox, J.S.G.

doi:10.1016/0041-008x(70)90043-8

Cited by 45 publications

(8 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…injec tion [3,4], but AH7725, unlike DSCG, is absorbed when administered orally and a dose related plasma concentration occurs. Because of this, a high oral dose might be expected to inhibit the PCA and PPA test for at least 2 h.…”

Section: Passive Cutaneous Anaphylaxis Reactionmentioning

confidence: 99%

Studies on the Inhibition of Cellular Anaphylaxis

Fullarton¹,

Martin²,

Vardey³

1973

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Section: Passive Cutaneous Anaphylaxis Reactionmentioning

confidence: 99%

Studies on the Inhibition of Cellular Anaphylaxis

Fullarton¹,

Martin²,

Vardey³

1973

Int Arch Allergy Immunol

View full text Add to dashboard Cite

“…Its metabolism and pharmacokinetics in animals have been studied by the use of radiolabelled drug (Moss et al, 1970;Ashton et al, 1973) given by various routes. Studies in man have been few, due to the lack of suitable analytical methodology, though Walker et al (1972) did investigate the metabolic profile of the drug in asthmatic patients using [14C]-sodium cromoglycate administered intravenously, orally and by inhalation.…”

Section: Introductionmentioning

confidence: 99%

The pharmacokinetics of sodium cromoglycate in man after intravenous and inhalation administration.

Neale¹,

Brown²,

Hodder³

et al. 1986

Brit J Clinical Pharma

View full text Add to dashboard Cite

1 The pharmacokinetics of sodium cromoglycate in four healthy volunteers after slow intravenous infusion have been evaluated following measurement of plasma concentrations by radioimmunoassay. The results confirm earlier findings that sodium cromoglycate is rapidly eliminated from the body and that the data can be fitted to a two compartment open model. 2 The pharmacokinetic parameters derived from the intravenous administration were used to evaluate the pharmacokinetics after inhalation administration via the Spinhaler. A model for absorption from the lungs is described which involves absorption at two different rates; this gives a better fit to the observed data than a single absorption rate.3 A fast absorption rate constant with a mean value of 0.54 min-' and a slower rate constant with a mean value of 0.0097 min-' were found. Of a mean total of 2.84 mg absorbed from a 20 mg inhaled dose, 0.68 ± 0.15 (s.e. mean) mg were absorbed at the fast rate and 2.17 ± 0.37 mg at the slower rate. These rates probably reflect absorption from different sites within the lungs. 4 The results may have important implications for interpretation of clinical findings.

show abstract

“…The volume of each sample was measured, and an aliquot was refrigerated for later assay of DSCG content. Assays were carried out by methods described pre-viously (Moss, Jones, Ritchie & Cox, 1971; (Moss & Ritchie, 1970;Moss et al, 1971;Walker, Evans, Richards & Paterson, 1972). Hence the DSCG reaching the airways partially appears as unchanged drug in urine, and urinary excretion is a useful indicator of the extent to which successful deposition of DSCG in its target organ occurs.…”

Section: Methodsmentioning

confidence: 99%

Disposition of disodium cromoglycate administered in three particle sizes.

Curry

Taylor

Evans

et al. 1975

Brit J Clinical Pharma

View full text Add to dashboard Cite

I Disodium cromoglycate (DSCG) was administered in three particle sizes to five human subjects. 2 Urinary excretion of DSCG, as a proportion of the dose, was highest following small particles; the lower values recorded following intermediate-sized and large particles were similar. 3 DSCG deposited in the mouth was highest following large particles; the lower values recorded following intermediate-sized and small particles were similar. 4 The data were examined in relation to the recent observation that the protective effect of small particles of DSCG is dramatically superior to that of large particles.

show abstract

Distribution and metabolism of disodium cromoglycate in rats

Cited by 45 publications

References 10 publications

Studies on the Inhibition of Cellular Anaphylaxis

Studies on the Inhibition of Cellular Anaphylaxis

The pharmacokinetics of sodium cromoglycate in man after intravenous and inhalation administration.

Disposition of disodium cromoglycate administered in three particle sizes.

Contact Info

Product

Resources

About