Distribution and morphology of ghrelin-immunopositive cells in the cerebellum of the African ostrich

Wang, Jiaxiang; Li, Peng; Zhou, Yue

doi:10.1016/j.tice.2012.06.004

Cited by 7 publications

(8 citation statements)

References 18 publications

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“…In the African ostrich, ghrelin has been detected in the stomach, intestines, and cerebellum (Wang et al, 2009;Wang et al, 2012). However, no studies have evaluated the distribution of ghrelin in the thymus of the African ostrich.…”

Section: Introductionmentioning

confidence: 99%

Distribution and Morphology of Ghrelin-Immunopositive Cells in the Thymus of the African Ostrich

Wang

Zhang

et al. 2017

Int. J. Morphol.

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Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor, has been detected in the thymus of multiple vertebrates. However, little is known about its distribution in the thymus of the African ostrich. In this study, we evaluated the distribution and morphological characteristics of ghrelin-producing cells in the thymus of the African ostrich. Our results revealed that the thymus consists of a capsule and a parenchyma, which comprises the cortex and medulla. Compared to the cortex, the medulla had a fewer number of thymocytes and a greater number of epithelial cells. Additionally, three thymic corpuscles were identified. Ghrelinimmunopositive (ghrelin-ip) cells were detected both in the cortex and medulla of the African ostrich thymus, specifically within epithelial cells and thymic corpuscles. On the other hand, no ghrelin-ip cells were detected within thymocytes. These results clearly demonstrate the presence of ghrelin-ip cells in the thymus of the African ostrich.

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Section: Introductionmentioning

confidence: 99%

Distribution and Morphology of Ghrelin-Immunopositive Cells in the Thymus of the African Ostrich

Wang

Zhang

et al. 2017

Int. J. Morphol.

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“…Ghrelin's actions through GHS-R1a have been implicated in regulating a variety of physiological processes, including stimulation of growth hormone release, modulation of glucose metabolism, enhancement of learning and memory, and energy balance [5]. Recently, it has also been speculated that ghrelin may have a physiological function in the cerebellum [7]. Some reports have suggested that ghrelin receptors modulate the activity of cerebellar circuits and may contribute to the control of motor behaviour [2,5,8].…”

Section: Introductionmentioning

confidence: 99%

“…Some reports have suggested that ghrelin receptors modulate the activity of cerebellar circuits and may contribute to the control of motor behaviour [2,5,8]. Ghrelin-immunopositive cells have been localized in the cerebellum, particularly in the Purkinje cell layer, and widespread distribution of GHS-R mRNA in the cerebellar cortex has also been reported [7,9,10]. Nonetheless, the exact functional roles of ghrelin in cerebellar Purkinje neurons, as well as the underlying mechanisms, remain still unknown.…”

Section: Introductionmentioning

confidence: 99%

Ghrelin suppresses Purkinje neuron P-type Ca2+ channels via growth hormone secretagogue type 1a receptor, the βγ subunits of Go-protein, and protein kinase A pathway

Sun

Shi

et al. 2014

Cellular Signalling

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“…Interestingly, injecting non-homologous Ghrelin polypeptides into animals significantly stimulated the release of GH. Preliminary studies in our laboratory have shown that Ghrelin immunopositive cells (Ghrelin-ip) are also widely distributed in many tissues and organs, such as the adrenal gland (Ye et al 2018), pancreas (Wang et al 2017), cerebellum (Wang et al 2012) and gastrointestinal tract (Wang et al 2011) of African ostriches. This distribution is partly similar to that in mammals, which suggested that Ghrelin's physiological role in the growth and development of African ostriches might be similar to that in mammals.…”

Section: Introductionmentioning

confidence: 99%

Effects of Exogenous Ghrelin on Feeding, Drinking and Growth Hormone Secretion in African Ostrich Chicks

Sun

Wang

et al. 2022

IJAR

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Background: Ghrelin is widely distributed in an animal’s body, playing important biological roles. In mammals, Ghrelin can stimulate food intake and weight gain, but in poultry, it inhibits food intake and drinking. We aimed to determine the effect of Ghrelin on feeding, drinking, body weight and growth hormone (GH) content of African ostrich chicks. Methods: Sixteen 40-day-old African ostrich chicks were randomly divided into four groups and injected intravenously with saline (control) or Ghrelin (10, 50 and 100 µg/kg) for 7 days. The feeding, drinking and growth hormone (GH) levels using measurement method and radioimmunoassay were determined. Result: The results show that exogenous Ghrelin increased the feed intake rate, the drinking rate and the secretion of GH in the ostriches.

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Distribution and morphology of ghrelin-immunopositive cells in the cerebellum of the African ostrich

Cited by 7 publications

References 18 publications

Distribution and Morphology of Ghrelin-Immunopositive Cells in the Thymus of the African Ostrich

Distribution and Morphology of Ghrelin-Immunopositive Cells in the Thymus of the African Ostrich

Ghrelin suppresses Purkinje neuron P-type Ca2+ channels via growth hormone secretagogue type 1a receptor, the βγ subunits of Go-protein, and protein kinase A pathway

Effects of Exogenous Ghrelin on Feeding, Drinking and Growth Hormone Secretion in African Ostrich Chicks

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