Distribution and origin of TRPV1 receptor-containing nerve fibers in the dura mater of rat

Shimizu, Toshihiko; Toriumi, Haruki; Sato, Hideki; Shibata, Mamoru; Nagata, Eiichiro; Gotoh, Kyoko; Suzuki, Noriyuki

doi:10.1016/j.brainres.2007.07.068

Cited by 67 publications

(51 citation statements)

References 24 publications

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“…Although previous studies had demonstrated the occurrence of TRPV1 receptors in the dura, the origin of the TRPV1 protein was not known. Retrograde labeling studies have demonstrated that 25% of the trigeminal ganglion cells projecting to the dura express TRPV1 and 80% of those express CGRP [42]. This high level of co-localization is consistent with reports that TRPV1 receptor activation in the dura stimulates CGRP release and subsequent vasodilatation [44][45][46].…”

Section: Trpv1 Localizationsupporting

confidence: 74%

“…TRPV1 is widely expressed in the anatomical substrates of migraine, particularly in soma of the trigeminal ganglion, nerve fibers, in central terminals in the TNC and in peripheral terminals within the dura [29,30,42,43]. Although previous studies had demonstrated the occurrence of TRPV1 receptors in the dura, the origin of the TRPV1 protein was not known.…”

Section: Trpv1 Localizationmentioning

confidence: 90%

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The Role of TRP Channels in Migraine

Oxford¹,

Hurley²

2013

TOPAINJ

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TRP channels are members of a large family of non-selective cation channels. The family which numbers over 30 is classified into 6 groups based on amino acid sequence homology. TRP channels are distributed in many peripheral tissues as well as central and peripheral nervous system. These channels are important in sensing a wide range of chemical and physical stimuli. Several TRP channels, including TRPV1 and TRPA1 are important in pain transduction pathways. This review will focus on the function of TRP channels in the trigeminovascular system and other anatomical regions which are relevant to migraine. We will discuss the possible role of TRP channels in migraine, including the potential role of TRPV1 in the hypersensitivity and allodynia frequently observed in migraine patients. We will review the status of TRP channel drugs in migraine therapeutics. We will also discuss the possible roles of TRP channels in triggering migraine attacks, a process which is not well-understood.

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Section: Trpv1 Localizationsupporting

confidence: 74%

Section: Trpv1 Localizationmentioning

confidence: 90%

The Role of TRP Channels in Migraine

Oxford¹,

Hurley²

2013

TOPAINJ

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“…Trigeminovascular system-mediated neurogenic inflammation in the duramater has been implicated in pathophysiology of headaches [308]. Recent reports confirm the presence of TRPV1 in duramater and suggest an association between TRPV1 and migraine headaches [309,310].…”

Section: Trpv1 In Cardiovascular Systemmentioning

confidence: 97%

Disease-Related Changes in TRPV1 Expression and Its Implications for Drug Development

Premkumar¹,

Bishnoi²

2011

CTMC

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The transient receptor potential vanilloid 1 (TRPV1) channel has been a topic of great interest, since its discovery in 1997. It is a homotetrameric non-selective cation channel predominantly expressed in a population of sensory neurons and its involvement in different modalities of pain has been extensively studied. However, TRPV1 has also been shown to be expressed in non-sensory neurons and non-neuronal cells. TRPV1 is considered as a potential target for drug development, based on its tissue distribution and its role in physiological functions. Here, we summarize the evidences for disease-related alterations in TRPV1 expression and function and review the current perspectives for the therapeutic potential of TRPV1 agonists and antagonists in the treatment of a wide range of diseases.

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“…110 Preclinically, TRPV1 has been shown on dural nerve fibers 111 as well as on trigeminal ganglion cell bodies retrogradely labeled from the dura. 112 Capsaicin can dilate dural vessels in a TRPV1-dependent mechanism, 113 and application of capsaicin to the rat dura produces ERK activation in trigeminal ganglion neurons 114 and behavioral responses consistent with headache.…”

Section: Transient Receptor Potential V1 (Trpv1)mentioning

confidence: 99%

Targeting TRP Channels For Novel Migraine Therapeutics

Dussor

Yan

Xie

et al. 2014

ACS Chem. Neurosci.

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Migraine is increasingly understood to be a disorder of the brain. In susceptible individuals, a variety of “triggers” may influence altered central excitability, resulting in the activation and sensitization of trigeminal nociceptive afferents surrounding blood vessels (i.e., the trigeminovascular system), leading to migraine pain. Transient receptor potential (TRP) channels are expressed in a subset of dural afferents, including those containing calcitonin gene related peptide (CGRP). Activation of TRP channels promotes excitation of nociceptive afferent fibers and potentially lead to pain. In addition to pain, allodynia to mechanical and cold stimuli can result from sensitization of both peripheral afferents and of central pain pathways. TRP channels respond to a variety of endogenous conditions including chemical mediators and low pH. These channels can be activated by exogenous stimuli including a wide range of chemical and environmental irritants, some of which have been demonstrated to trigger migraine in humans. Activation of TRP channels can elicit CGRP release, and blocking the effects of CGRP through receptor antagonism or antibody strategies has been demonstrated to be effective in the treatment of migraine. Identification of approaches that can prevent activation of TRP channels provides an additional novel strategy for discovery of migraine therapeutics.

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Distribution and origin of TRPV1 receptor-containing nerve fibers in the dura mater of rat

Cited by 67 publications

References 24 publications

The Role of TRP Channels in Migraine

The Role of TRP Channels in Migraine

Disease-Related Changes in TRPV1 Expression and Its Implications for Drug Development

Targeting TRP Channels For Novel Migraine Therapeutics

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