2016
DOI: 10.1016/j.msard.2016.03.007
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Distribution-based estimates of minimum clinically important difference in cognition, arm function and lower body function after slow release-fampridine treatment of patients with multiple sclerosis

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Cited by 33 publications
(29 citation statements)
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“…Using a distribution-method approach, the MCID was estimated at -3.7 seconds (-27%) in patients with multiple sclerosis 44 .…”
Section: Discussionmentioning
confidence: 99%
“…Using a distribution-method approach, the MCID was estimated at -3.7 seconds (-27%) in patients with multiple sclerosis 44 .…”
Section: Discussionmentioning
confidence: 99%
“…In this context, we propose TMS as a useful tool not only for investigation of the relapse in MS, but also for follow-up of specific symptomatic treatments, such as Fampridine. It can be used for measurements Fampridine is known to improve ambulation and endurance, but also, by the same mechanism of enhancing action potential formation in demyelinated axons by blocking potassium channels, it appears to improve cognitive fatigue as well (14,15). Fampridine also seems to improve muscle strength and the rate of force development as measured not only by T25FW, but also by isokinetic dynamometry, Nine Hole Peg Test and other muscle strength or manual functions monitoring tests (16,17).…”
Section: Discussionmentioning
confidence: 99%
“…All forms of MS were included (relapsing remitting, primary progressive, secondary progressive) [12]. There were wide variations in terms of age, ranging from 18 to 70 years [8,[13][14][15][16] or from 18 to 60 years [17,18].…”
Section: Choice Of Participantsmentioning
confidence: 99%
“…When it was taken into account, the score had to be between 4 and 7 inclusive [17][18][19][20][21][22] or between 3.5 and 6.5 [23]. However, for the majority of studies (17 of 18), gait disorders had to be established objectively before treatment by using the timed 25-foot walk (T25FW).…”
Section: Choice Of Participantsmentioning
confidence: 99%
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