Distribution Characteristics of 3,369 Chinese Colorectal Cancer Patients for Gender, Age, Location and Tumor Size During Colonoscopy

Cai, Bin; Wang, Mu-Yong; Liao, Kai; Xu, Yali; Wei, Weiyuan; Zhuang, Yuan; Zhang, Sen

doi:10.7314/apjcp.2014.15.20.8951

Cited by 12 publications

(11 citation statements)

References 28 publications

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“…Our results are consistent with those observed in China and Africa, where the most affected site is the rectum and the least reached one is proximal colon [40,47,64]. This is not the case in developed countries as in the USA and Canada, where the most affected site is the proximal colon followed by the rectum [5,48,50,60,65].…”

Section: Discussionsupporting

confidence: 91%

“…Patients over 50 years old accounted for 75%, which is close to that observed in Morocco (75%) and China (72%) [38,40,47], but remains lower than Westernized countries where over 90% of CRCs occur in people over 50 years [5,[48][49][50]. The proportion of patients under 40 years (9%), observed in this study is higher compared with those observed in developed countries such as the USA and France, where CRC in young patients is very rare before 40 years and accounts for 1-4% [44,48,50].…”

Section: Discussionsupporting

confidence: 73%

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Colorectal cancer incidence and clinicopathological features in northern Tunisia 2007–2009

Khiari

Hsaïri

2018

Colorect. Cancer

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Colorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide. The aim of this study was to determine CRC incidence and to describe clinicopathological features in north Tunisia for the period 2007–2009. The North Tunisia Cancer Registry was the source of data for the identification of patients. The age-standardized incidence rates (ASRs) were respectively 13.6 cases (7.5/100,000 for colon cancer and 6.2 for rectal cancer) and 11.1 cases (6.5/100,000 for colon cancer and 4.4 for rectal cancer) per 100,000 among male and female. The ASR varied widely by regions in northern Tunisia. The most common site in colon cancer was the distal colon comparing to the proximal one (49.0 and 29.9% respectively). Adenocarcinoma was the most common histological type. CRC screening should be strengthened in Tunisia to achieve a reduction of CRC incidence and mortality.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 73%

Colorectal cancer incidence and clinicopathological features in northern Tunisia 2007–2009

Khiari

Hsaïri

2018

Colorect. Cancer

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“…We did not find any difference in the distribution of tumor (rectum vs. colon) between young and non-Young CRC groups, similar to findings from other studies looking at early onset CRC (Hav et al, 2011;Quach & Nguyen, 2012) or overall CRC cases (Cai et al, 2014). However a study from the United States reported a higher incidence of rectal cancer in persons younger than 50 years compared to older adults (Fairley et al, 2006), and several other studies have reported increasing incidence of rectal cancer among the younger population (Siegel et al, 2009;Meyer et al, 2010;Ahnen et al, 2014).…”

Section: Discussionsupporting

confidence: 91%

Characteristics of Young Colorectal Cancer in Brunei Darussalam: an Epidemiologic Study of 29 Years (1986-2014)

Koh¹,

Telisinghe²,

Bickle³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: Colorectal cancer (CRC) is the most common gastrointestinal cancer and the incidence is increasing. CRC is more common with increasing age, but a proportion occurs in young adults, termed young CRC. This study assessed the incidence and the demographic of young CRC in Brunei Darussalam. Materials and Methods: All histologically proven CRC between 1986 and 2014 registered with the Department of Pathology cancer registry were reviewed and data extracted for analyses. Young CRC was defined as cancer in patients aged less than 45 years. The various population groups were categorized into locals (Malays, Chinese and Indigenous) and expatriates. Results: Over the study period, there were 1,126 histologically proven CRC (mean age 59.1 ± 14.7 years, Male 58.0%, Locals 91.8% and 8.2% expatriates). Young CRC accounted for 15.1% with the proportion declining over the years, from 29% (1986-1990) to 13.2% (2011-2014). The proportion of young CRC was highest among the indigenous (30.8%), followed by the expatriates (29.3%), Malays (14.3%) and lowest among the Chinese (10.8%). The mean age of young CRC was 35.9 ± 6.2; lowest among the indigenous (33.5 ± 6.7), expatriate (34.9 ± 6.0) groupd and the Malays (35.6 ± 6.5) compared to the Chinese (38.6 ± 4.6), a similar trend being observed in the non-young CRC groups. There were no difference between the genders and tumor locations (rectum or colon) between the young and the non-young CRC cases. Female young CRC was significantly younger than male (p<0.05) without any significant variation between the various population groups (p>0.05). Conclusions: Our study showed that the young CRC accounted for 15.1% of all CRC with declining trend observed over recent years. Young CRC was more common among indigenous, expatriates and Malays and least common among the Chinese. There were no differences in the gender and tumor locations.

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“…Right sided colon cancers usually present among the elderly and many believe that they have more advanced stage at the time of diagnosis [ 12 - 14 ]. In contrast to our findings, the proportion of female patients with cecum adenocarcinoma was higher in several other studies [ 4 , 15 , 16 ].…”

Section: Discussionmentioning

confidence: 99%

Prognostic significance of adjuvant radiation therapy in adenocarcinoma of the cecum

et al. 2018

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PurposeLocal recurrence is a common failure pattern in adenocarcinoma of the cecum. This study aimed to investigate the potential role of adjuvant radiation therapy on oncologic outcomes of patients with adenocarcinoma of the cecum.Materials and MethodsThis retrospective study was carried out at three large tertiary university hospitals. We analyzed the characteristics, prognostic factors, and survival of 162 patients with adenocarcinoma of the cecum that were treated and followed up between 2000 and 2013. All the patients had undergone a right hemicolectomy and received chemotherapy with (n = 48) or without (n = 114) adjuvant radiation therapy.ResultsThe subjects were 65 females and 97 males with a median age of 56 years (range, 17 to 90 years) at diagnosis. The 5-year local control (LC), disease free survival (DFS), and overall survival (OS) rates were 72.7%, 57.2%, and 62.6% respectively. In a multivariate analysis, age, tumor stage, node stage, and adjuvant radiation therapy were determined to be independent prognostic factors. Age more than 55 years (hazard ratio [HR] = 1.0; 95% confidence interval [CI], 0.06–0.32; p = 0.003], T4 stage (HR = 6.8; 95% CI, 3.07–15.36; p < 0.001), node positive disease (HR = 4.2; 95% CI, 1.94–9.13; p < 0.001), and the absence of adjuvant radiation therapy (HR = 3.0; 95% CI, 1.39–6.46; p = 0.005) had a negative influence on OS.ConclusionAdjuvant radiation therapy significantly improves DFS and OS in patients with adenocarcinoma of the cecum.

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Distribution Characteristics of 3,369 Chinese Colorectal Cancer Patients for Gender, Age, Location and Tumor Size During Colonoscopy

Cited by 12 publications

References 28 publications

Colorectal cancer incidence and clinicopathological features in northern Tunisia 2007–2009

Colorectal cancer incidence and clinicopathological features in northern Tunisia 2007–2009

Characteristics of Young Colorectal Cancer in Brunei Darussalam: an Epidemiologic Study of 29 Years (1986-2014)

Prognostic significance of adjuvant radiation therapy in adenocarcinoma of the cecum

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