Distribution Features of Skeletal Metastases: A Comparative Study between Pulmonary and Prostate Cancers

Wang, Changyin; Ying, Shao‐Yao; Zhu, Shirley

doi:10.1371/journal.pone.0143437

Cited by 21 publications

(15 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Especially among patients with only one bone containing a metastasis but no visceral metastases, we observed the characteristics of bone metastatic distribution that neighboring bones to the primary were more likely to be first metastasized. This also correspond to previous findings that the differences in the distribution of bone metastases between pulmonary, breast and prostate cancers [7], [11].…”

Section: Discussionsupporting

confidence: 92%

“…Metastases carried through the circulatory system may spread to any bone in the body, as this pathway is considered to be random [7]. Although numerous studies have been published about systemic circulatory bone metastases, few studies had addressed bone metastasis through the vertebral venous plexus [8], [9], [10], [11], and the pattern of vertebral venous plexus related bone metastasis had not been elucidated.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Bone metastasis pattern of cancer patients with bone metastasis but no visceral metastasis

Zhu

Liu

et al. 2019

Journal of Bone Oncology

View full text Add to dashboard Cite

BackgroundBone metastasis of cancer can be a result from systemic blood spreading or vertebral venous plexus spreading. Systemic blood pathway induced bone metastasis can happen in any bone in the body since the spreading is considered to be random. However, it remains unknown whether there is any pattern of vertebral venous plexus related bone metastasis. In this study, we explored bone metastasis patterns in patients whose primary tumors had been well identified.MethodsWe included 290 consecutive cancer patients with bone metastases but no visceral metastases, out of 2559 patients whose bone metastases were diagnosed by positron emission tomography/computed tomography, between Jan 2015 and Oct 2017 at the Fudan University Shanghai Cancer Center. We excluded those with visceral metastasis to ensure that our study focused on metastasis through the vertebral venous plexus. And we analyzed the distribution and pattern of skeletal metastases.ResultsOf the 290 patients, 28 had head and neck tumors, 178 had thorax tumors, 49 had abdominal tumors and 35 had pelvic tumors; 102 (35%) had only one bone containing a metastasis and 188 (65%) had multiple bones containing metastases. Overall, metastases to the thoracic skeleton were more common in patients with thorax tumors than in other patients (81% vs. 67%, P = 0.007); metastases to the cervical spine or thoracic bones were more common in patients with primary tumors above the diaphragm than those below the diaphragm (82% vs. 66%, P = 0.002). Among those with only one bone containing a metastasis (n = 102), patients with head and neck tumors had a higher incidence of cervical spine metastasis than other patients (25% vs. 2%, P = 0.03), those with thorax tumors had a higher incidence of thoracic bone metastasis than other patients (56% vs. 35%, P = 0.035), and those with pelvic tumors had a higher incidence of pelvis bone metastasis than other patients (78% vs. 27%, P = 0.000054).ConclusionsIn patients with only one bone containing a metastasis but no visceral metastasis, bones near the primary were more likely to be first metastasized. This may be a valuable clue to primary tumor sites in patients with cancers of unknown primaries.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Bone metastasis pattern of cancer patients with bone metastasis but no visceral metastasis

Zhu

Liu

et al. 2019

Journal of Bone Oncology

View full text Add to dashboard Cite

show abstract

“…While, previous researchers found that the ribs then the spinal region were the most common sites 3,8 which can be attributed to direct tumor invasion.…”

Section: Discussionmentioning

confidence: 92%

Study of distribution of bone metastases in metastatic breast cancer patients compared to other major cancers

Tawfik

Zytoon

Gohar

2016

Kasr-Al-Aini J.of Clin. Onc. and Nuc. Med.

View full text Add to dashboard Cite

INTRODUCTIONFor metastatic carcinomas, skeletal metastases are the third most common following pulmonary and hepatic. In addition, bone metastases may present as the first manifestation of cancer in 25-30% of cases 1 .The most common malignant tumors that metastasize to bone are prostate cancer in males and breast cancer in females and lung cancer in both. Also, any malignant tumor can metastasize to bone 2 .Studying the pattern of distribution of skeletal metastases can help in diagnosis and narrow the diagnostic differentials.This study aimed to assess the pattern of bone metastases in breast cancer patients compared to other common cancers using Technetium-99m-methylene diphosphonate skeletal scintigraphy. Besides, to explore if there is a specific distribution of bony deposits in breast cancer patients compared to other major malignancies in order to reduce diagnostic differentials. METHODSWe studied whole-body bone scans of 150 cancer patients which was done to exclude or assess metastatic bone disease. Anterior and posterior views were obtained with a dual detector gamma camera for patients who had undergone scintigraphy with Tc-99m methylene diphosphonate (600 MBq Tc-99m MDP).Bone scans were interpreted as positive for bone metastasis if radiotracer activity of local bone lesion was greater or less than that of adjacent or contralateral normal bone. Introduction: Metastatic bone disease is frequent in patients with advanced breast cancer. Although it is not specific for the detection of metastatic bony lesions, bone scan is a sensitive method. The pattern of distribution of bone metastases as detected by bone scan combined with clinical data may help in reaching diagnosis. Methods: Technetium-99m-methylene diphosphonate skeletal scintigraphy was used for evaluation of distribution pattern of skeletal metastases in patients with breast carcinoma compared to other common cancers. Results: Out of 134 patients with positive bone scan for skeletal deposits, the primary cancer was breast cancer in 81 patients, prostate in 24, lung in 12, liver in 8, urinary bladder in 6, and head and neck in 3. Few metastases (≤ 3 deposits) were common in breast cancer, while extensive metastatic lesions (≥10 deposits) were more common in prostate cancer (50%). The most common locations of bone metastases in patients with breast cancer were the spine, pelvic bones, femora, and ribs, respectively. In prostate cancer patients, spine was the most common site of metastases, especially the lumber region. In lung cancer patients, thoracic spine was the most common site of metastases, while pelvic bones were the most common site in liver cancer patients. Conclusion: In breast cancer, the most frequent sites of involvement are the spine (especially lumber region), pelvis and axial skeleton, respectively. Spinal and sternal involvements are significantly more in breast cancer than in other malignancies.

show abstract

“…The bony pelvis is a favored site for PCa bone metastases (14, 15). Additionally, patients who develop pelvic bone metastases may have worse OS (16).…”

Section: Introductionmentioning

confidence: 99%

Patterns of Bone Failure in Localized Prostate Cancer Previously Irradiated: The Preventive Role of External Radiotherapy on Pelvic Bone Metastases

et al. 2019

View full text Add to dashboard Cite

Introduction: External beam radiation therapy (EBRT) can cure localized prostate cancer (PCa) by sterilizing cancer cells in the prostate gland and surrounding tissues at risk of microscopic dissemination. We hypothesized that pelvic EBRT for localized PCa might have an unexpected prophylactic impact on the occurrence of pelvic bone metastases. Material and Methods: We reviewed the data of 332 metastatic PCa patients. We examined associations between the number (≤5 vs. >5) and the location of bone metastases (in-field vs. out-of-field), which occurred at first relapse, and a previous history of EBRT for PCa (EBRT vs. No-EBRT). Results: One hundred and ten patients M0 at baseline were eligible. Fifty-six patients (51%) were in the No-EBRT group, and 54 patients (49%) in the EBRT group. The proportion of patients who developed >5 bone metastases in the bony pelvis was higher in the No-EBRT group vs. the EBRT group: 10 patients (18%) vs. 2 patients (4%), respectively ( p = 0.02). By multivariate analysis EBRT was associated with a lesser occurrence of patients who had >5 bone metastases in the bony pelvis (OR = 0.17 [95%CI, 0.04–0.87], p = 0.03). Time to occurrence of bone metastases ≥5 years (OR = 0.10 [95%CI, 0.05–0.19], p < 0.01), prior curative prostate treatment (OR = 0.58 [95%CI, 0.36–0.91], p = 0.02), >5 bone metastases in bony pelvis (OR = 2.61 [95%CI, 1.28–5.31], p < 0.01), >5 bone metastases out of bony pelvis (OR = 1.73 [95%CI, 1.09–2.76], p = 0.02) were all predictive of overall survival. Conclusion: Previous pelvic EBRT for PCa is associated with a lower number of pelvic bone metastases, which is associated with better overall survival.

show abstract

Distribution Features of Skeletal Metastases: A Comparative Study between Pulmonary and Prostate Cancers

Cited by 21 publications

References 23 publications

Bone metastasis pattern of cancer patients with bone metastasis but no visceral metastasis

Bone metastasis pattern of cancer patients with bone metastasis but no visceral metastasis

Study of distribution of bone metastases in metastatic breast cancer patients compared to other major cancers

Patterns of Bone Failure in Localized Prostate Cancer Previously Irradiated: The Preventive Role of External Radiotherapy on Pelvic Bone Metastases

Contact Info

Product

Resources

About