Numerical calculations of anisotropic hopping transport based on the resistor network model are presented. Conductivity is shown to follow the stretched exponential dependence on temperature with exponents increasing from 1 4 to 1 as the wave functions become anisotropic and their localization length in the direction of charge transport decreases. For sufficiently strong anisotropy, this results in nearest-neighbor hopping at low temperatures due to the formation of a single conduction path, which adjusts in the planes where the wave functions overlap strongly. In the perpendicular direction, charge transport follows variable-range hopping, a behavior that agrees with experimental data on organic semiconductors.