Distribution of a polychlorinated terphenyl (PCT) (Aroclor® 5460) in rat tissues and effect on hepatic microsomal mixed function oxidases

Jc, Sosa-Lucero; Fa, de la Iglesia; Gh, Thomas

doi:10.1007/bf01684553

Cited by 19 publications

(4 citation statements)

References 17 publications

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“…The results of a study on the metabolism of a polychlorinated terphenyl mixture in rats are consistent with the general conclusion for the metabolism of chlorinated aromatics that the rate of metabolism is inversely related to the degree of chlorine substitution (200).…”

Section: )supporting

confidence: 72%

Halogenated benzenes, naphthalenes, biphenyls and terphenyls in the environment: Their carcinogenic, mutagenic and teratogenic potential and toxic effects^a

Lai¹

1984

Journal of Environmental Science and Health. Part C: Environmen

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Section: )supporting

confidence: 72%

Halogenated benzenes, naphthalenes, biphenyls and terphenyls in the environment: Their carcinogenic, mutagenic and teratogenic potential and toxic effects^a

Lai¹

1984

Journal of Environmental Science and Health. Part C: Environmen

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“…It has been established with studies on chlorinated aromatic compounds that the rate of metabolism and excretion is dependent on the amount of chlorine in the molecule. The lower chlorinated isomers are metabolized extremely rapidly (Bailey and Bunyan, 1972;Sosa-Lucero et al, 1973). It remains to be determined if lower brominated isomers would be metabolized and excreted faster than the primarily hexabromobiphenyl compound used in this study.…”

Section: Resultsmentioning

confidence: 97%

Polybrominated biphenyls. Tissue distribution and effect on hepatic microsomal enzymes in Japanese quail

Babish¹,

Gutenmann²,

Stoewsand³

1975

J. Agric. Food Chem.

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POLYBROMINATED BIPHENYLS tained an unknown (Rf 0.27) in the alachlor experiment and an unknown (Rf 0.30) in the propachlor experiment (Tables III and IV). According to Lamoureux et al. (1971) and Sharp (1972), these herbicides in the plants were rapidly conjugated with nature products as transitory metabolites. Two of them have been identified as conjugates of glutathion and -glutamylcystein. Since model metabolites were not available at the time and these metabolites and degradation products did not accumulate in the food-chain organisms (Tables III and IV), no attempt was made to identify them.Total 14C was higher in organisms than in water. For example, snail accumulated 24 times more alachlor metabolites than did the water. We do not know whether this constitutes an environmentally acceptable level, but we do know that the accumulation is much less than that of organochlorine pesticides such as DDT which is concentrated over several thousand times more in organisms than in water (Metcalf et al., 1971).In summary, alachlor and propachlor were rapidly degraded in the water. There was no evidence to indicate that these two herbicides and their degradation products were magnified in the food chain. For example, the total radioactivity in a food chain from algae -* mosquito -*• fish decreased from 0.66 to 0.23 ppm in alachlor, and from 0.21 to 0.015 ppm in propachlor. ACKNOWLEDGMENTThe provision of ring-14C-labeled alachlor and propa-chlor by Monsanto Co., St. Louis, Mo., is appreciated. The cooperation of W. F. Childers, Section of Aquatic Biology, Illinois Natural History Survey, who provided some of the aquatic organisms, is greatly appreciated. LITERATURE CITED Booth, G.

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“…Following exposure to PCTs, an increased turnover rate has been demonstrated for cytochrome P450-dependent reactions such as aromatic hydroxylation and Nhydroxylation, N-and O-dealkylation, aromatic nitro reduction, and glucuronidation. Interestingly, both phenobarbitaland 3-methylcholanthrene-inducible forms of cytochrome P450 were affected (47,52,(56)(57)(58)(59)(60). The activities of epoxide hydrolase and glutathione S-transferases were not changed (60).…”

Section: Discussionmentioning

confidence: 89%

“…The main target organ for chronic PCT toxicity, nevertheless, was the liver. Aroclor 5460 caused a dose-dependent increase in relative liver weight and proliferation of the smooth endoplasmatic reticulum in rats (47,52) and monkeys (54). The affected liver microsomes had a higher content of proteins, and the structures of the membranes were less stable.…”

Section: Discussionmentioning

confidence: 99%

Occurrence of polychlorinated terphenyls (PCTs) in indoor particulate matter.

Seidel

Schweizer

Schweinsberg

et al. 1996

Environ Health Perspect

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In the course of a routine investigation concerned with polychlorinated biphenyl (PCB) contamination of dust collected in classrooms of a junior high school, a group of electron capture detector (ECD)-sensitive compounds with high boiling points were found in addition to PCBs. Using gas chromatographic-mass spectrometric techniques, these compounds were identified as polychlorinated terphenyls (PCTs). Additional measurements indicated that the PCTs were present only in particulate matter collected from the tops of fluorescent light frames but not in air samples obtained concomitantly in the classrooms. Attempts to identify the PCT emission source were unsuccessful. A survey of the literature revealed that PCTs are ubiquitously distributed environmental contaminants, although no data on their indoor occurrence have been reported to date. In view of the toxic effects of PCTs, which seem to be as important as those of PCBs, further attention should be given to the possible presence of PCTs in indoor environments. Images Figure 1. Figure 2. Figure 3. Figure 4.

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Distribution of a polychlorinated terphenyl (PCT) (Aroclor® 5460) in rat tissues and effect on hepatic microsomal mixed function oxidases

Cited by 19 publications

References 17 publications

Halogenated benzenes, naphthalenes, biphenyls and terphenyls in the environment: Their carcinogenic, mutagenic and teratogenic potential and toxic effects^a

Halogenated benzenes, naphthalenes, biphenyls and terphenyls in the environment: Their carcinogenic, mutagenic and teratogenic potential and toxic effects^a

Polybrominated biphenyls. Tissue distribution and effect on hepatic microsomal enzymes in Japanese quail

Occurrence of polychlorinated terphenyls (PCTs) in indoor particulate matter.

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Distribution of a polychlorinated terphenyl (PCT) (Aroclor® 5460) in rat tissues and effect on hepatic microsomal mixed function oxidases

Cited by 19 publications

References 17 publications

Halogenated benzenes, naphthalenes, biphenyls and terphenyls in the environment: Their carcinogenic, mutagenic and teratogenic potential and toxic effectsa

Halogenated benzenes, naphthalenes, biphenyls and terphenyls in the environment: Their carcinogenic, mutagenic and teratogenic potential and toxic effectsa

Polybrominated biphenyls. Tissue distribution and effect on hepatic microsomal enzymes in Japanese quail

Occurrence of polychlorinated terphenyls (PCTs) in indoor particulate matter.

Contact Info

Product

Resources

About

Halogenated benzenes, naphthalenes, biphenyls and terphenyls in the environment: Their carcinogenic, mutagenic and teratogenic potential and toxic effects^a

Halogenated benzenes, naphthalenes, biphenyls and terphenyls in the environment: Their carcinogenic, mutagenic and teratogenic potential and toxic effects^a