Distribution of ABO blood group allele and identification of three novel alleles in the Chinese Han population

Zhu, Faming; Tao, Sudan; Xu, Xianguo; Ying, Yanling; Hong, Xiaozhen; Zhu, Hong; Yan, L.‐X.

doi:10.1111/j.1423-0410.2009.01291.x

Cited by 57 publications

(76 citation statements)

References 22 publications

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“…For example, the A101 , O01 , B101 , A102 , and O02 alleles are common in Asian populations [14]. Alleles such as O04 and A205 are found in the Han Chinese, and allele O06 is found in the Japanese [56]. Rare alleles such as cis-AB01 , cis-AB02 , and cis-AB06 are more frequently encountered in the Japanese, Korean, and Chinese populations [578].…”

Section: Introductionmentioning

confidence: 99%

Allelic variance amongABOblood group genotypes in a population from the western region of Saudi Arabia

et al. 2016

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BackgroundCharacterization of the ABO blood group at the phenotype and genotype levels is clinically essential for transfusion, forensics, and population studies. This study elucidated ABO phenotypes and genotypes, and performed an evaluation of their distribution in individuals from the western region of Saudi Arabia.MethodsOne-hundred and seven samples underwent standard serological techniques for ABO blood group phenotype analysis. ABO alleles and genotypes were identified using multiplex polymerase chain reaction, and electrophoretic analysis was performed to evaluate the highly polymorphic ABO locus.ResultsA phenotype distribution of 37.4%, 30.8%, 24.3%, and 7.5% was found for blood groups O, A, B, and AB respectively in our study cohort. Genotype analysis identified 10 genotype combinations with the O01/O02 and A102/O02 genotypes being the most frequent with frequencies of 33.6% and 14.95%, respectively. Common genotypes such as A101/A101, A101/A102, A101/B101, B101/B101, and O01/O01 were not detected. Similarly, the rare genotypes, cis-AB01/O02, cis-AB01/O01, and cis-AB01/A102 were not found in our cohort. The most frequently observed allele was O02 (35.98%) followed by the A102 allele (17.76%). Furthermore, our findings are discussed in reference to ABO allele and genotype frequencies found in other ethnic groups.ConclusionThe study has a significant implication on the management of blood bank and transfusion services in Saudi Arabian patients.

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Section: Introductionmentioning

confidence: 99%

Allelic variance amongABOblood group genotypes in a population from the western region of Saudi Arabia

et al. 2016

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“…Further sequencing analysis of exons 6 and 7 of the ABO gene revealed the mutation sites of the four CisAB members. It has been well known that sequence variations were detected in the six different CisAB alleles compared with some of the ABO alleles [9][10][11][12][13][14][15] (Table 2) (Table 2), which are identical to the well-documented CisAB01 /B101 genotype [9].…”

Section: Resultsmentioning

confidence: 99%

“…They found that the unique mutations of 467 C > T, 796 C > A and 803 G > C explained the molecular genetic basis of the CisAB phenotype. Six types of CisAB genotypes have been reported since it was first described in 1964: CisAB01 (467 C > T and 803 G > C) [11], CisAB02 (526 C > G, 657 C > T, 703 G > A and 803 G > C) [12], CisAB03 (297 A > G, 526 C > G, 657 C > T, 700 C > T, 703 G > A, 796 C > A, 803 G > C and 930 G > A) [13], CisAB04 (467 C > T and 796 C > A) [13], CisAB05 (163 T > C, 179 C > T, 467 C > T and 803 G > C) [14] and CisAB06 (297 A > G, 657 C > T, 703 G > A, 796 C > A, 803 G > C and 930 G > A) [15]. The incidence of the CisAB phenotype is very low; it is approximately 0.0014% in the Japanese population.…”

Section: Article In Pressmentioning

confidence: 99%

The serological and genetic characterization of CisAB blood group in a Chinese family

Zhao

Miao

Fang

et al. 2015

Transfusion and Apheresis Science

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“…Common alleles of ABO blood groups are A101, A102, B101, O01, and O02 (Zhu et al, 2010). To date, approximately 200 ABO alleles have been identified (Blumenfeld and Patnaik, 2004).…”

Section: Discussionmentioning

confidence: 99%

“…Although their frequencies are relatively low, these alternate alleles serologically manifest mainly as differentially expressed ABO blood group antigens and by phenomena such as the weakening of antigen strength, mixed-field-agglutination, and inconsistent positive and negative stereotypes in blood typing (Issitt and Anstee, 1998). Furthermore, molecular diagnostic techniques have also been used to clarify the molecular mechanisms of these partial ABO subtypes (Seltsam et al, 2003;Roubinet et al, 2004;Sun et al, 2006;Zhu et al, 2010). We found one case of the A 2 B subtype in clinical blood typing, and here report its molecular mechanism and results of the pedigree analysis.…”

Section: Introductionmentioning

confidence: 95%

α-1,3-N-acetylgalactose aminotransferase gene 539G>C mutation leads to the A2B isoform

2014

Genet. Mol. Res.

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ABSTRACT. In this study, the phenotypic identification and molecular mechanism of one case of an A 2 B subtype pedigree was investigated. ABO blood groupings were identified by serological methods and sequence amplification was performed by polymerase chain reaction (PCR) using TA cloning and DNA sequencing analysis to identify the pedigree and the ABO gene haploid of the proband. There were both A and B antigens on the proband's red blood cells, and anti-A 1 antibodies were found in the serum. Direct sequencing of the 6th and 7th exons of the ABO gene showed the A208/B101 genotype, and haploid determination revealed the A208 and B101 alleles. Compared with the A102 allele sequence, the A208 allele was mutated at the 539 G>C site. Pedigree analysis showed that the ABO blood phenotypes of the proband's father, mother, husband, and daughter were A2, B, AB, and A 2 B, respectively, and their genotypes were A208/O02, B101/ B101, A102/B101, and A208/B101, respectively. The father of the proband had anti-A 1 antibodies and the A208 allele of the proband was inherited from her father, which can be passed on to her daughter. The α-1, 3-N-acetylgalactose aminotransferase gene 539G>C mutation

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Distribution of ABO blood group allele and identification of three novel alleles in the Chinese Han population

Abstract: The detailed frequencies distribution of ABO alleles was studied in the Chinese Han population. We identified 14 alleles, including 3 novel alleles.

Cited by 57 publications

References 22 publications

Allelic variance amongABOblood group genotypes in a population from the western region of Saudi Arabia

Allelic variance amongABOblood group genotypes in a population from the western region of Saudi Arabia

The serological and genetic characterization of CisAB blood group in a Chinese family

α-1,3-N-acetylgalactose aminotransferase gene 539G>C mutation leads to the A2B isoform

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