Distribution of adenosine triphosphatase activity in the developing brain of the chick embryo

Chick embryos between the 15th and 20th day of incubation were subjected to hypothermia of 20°C followed by nitrogenous hypoxia until the cerebral EEG showed no fluctuations of potential. The embryos were exposed to ah 15 or 30 min later. Body temperature was raised to 30°C and maintained there for 1 hr before being raised to 36"C, during which time 2 types of sehure episodes of rhythmic waves appeared. Type I was characterized by an ontogenetically later appearance (after the 15th day), larger amplitude, spike and slow wave patterns, a frequency of .3-3.5 Hz with the slowest in the younger embryos, and a duration of 1 to several minutes. Type I1 was characterized by an earlier ontogenetic appearance, small amplitude, a frequency of 1-30 Hz, and a duration of a few seconds to several minutes. None of these seizure episodes was observed after body temperature had reached 36°C. About the 17th day of incubation, the physiological components responsible for producing EEG patterns during episodes seem to undergo an abrupt maturational change indicated by the increase in percentage of embryos undergoing Type I episodes, and by changes in frequency of waves and duration of episodes.The observation has been repeatedly made that in developing animals hypoxic stress causes the earlier cessation of function of ontogenetically newer structures in the central nervous system (

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Ontogenesis of electroencephalographic seizure patterns in developing chick embryos during recovery from hypothermic hypoxia

Peters

Hilgeford

Vonderahe

1973

Developmental Psychobiology

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Morphological, biochemical, and functional changes in chick embryonic brain tissue after intracerebral administration of ouabain

Sedláček

Šťastný

1973

Developmental Psychobiology

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The manifestations of intracerebral administration of 3.4 x 10-4M ouabain were studied in 15and 19-day-old chick embryos. No significant changes in the histological structure of the cerebrum were detected in 15-day-old embyros. The (Na' -K+)-ATPase activity was completely suppressed, however, and the spontaneous bioelectric activity was inhibited. In 19-day-old embyros distinct swelling and vacuolization of the cellular elements occurred. The (Na' -K+)-ATPase activity was inhibited to the same extent in 19-day-old as in 15-day-old cerebral tissue. Ouabain administration resulted in episodes of spike-and-wave paroxysmal activity in the EEG of 19-day-old embyros, characterized by high amplitude and low frequency discharges. Spontaneous motor activity was inhibited following an initial transient increase. In some cases short episodes of hyperactivity were registered, regularly followed by complete inactivity.

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Influence of age and short‐term starvation on the ATPase activity in the developing rat brain

Mourek

Šťastný

1978

Developmental Psychobiology

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Na+-K+-stimulated and Mg++-dependent ATPase activities were investigated in the developing cerebral cortex, subcortical structures, and medulla oblongata of rats as was the effect of 24-hr lasting starvation and thirst on those enzyme activities. We found (a) a developmental increase of these ATPase activities in the developing rat brain with the maximum in the cerebral cortex and with the minimum in the medulla oblongata; (b) a decrease of the ratio of these enzyme activities, which was near unity in adult animals; (c) an increase of ATPase activities in the cerebral cortex and subcortical formations of young rats under starvation conditions followed by a decrease of the Mg++/Na+-K+-ATPase activity ratios in these structures; and (d) a decrease of these activities, especially in the cerebral cortex, and an increase of the activity ratios in adult animals under starvation conditions.

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Distribution of adenosine triphosphatase activity in the developing brain of the chick embryo

Cited by 7 publications

References 29 publications

Ontogenesis of electroencephalographic seizure patterns in developing chick embryos during recovery from hypothermic hypoxia

Ontogenesis of electroencephalographic seizure patterns in developing chick embryos during recovery from hypothermic hypoxia

Morphological, biochemical, and functional changes in chick embryonic brain tissue after intracerebral administration of ouabain

Influence of age and short‐term starvation on the ATPase activity in the developing rat brain

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