Distribution of Adiponectin, Leptin, and Metabolic Correlates of Insulin Resistance: A Longitudinal Study in British Children; 1: Prepuberty (EarlyBird 15)

Murphy, Michael J.; Hosking, J; Metcalf, Brad; Voss, Linda D; Jeffery, Alison; Sattar, Naveed; Williams, Rhodri; Jeffery, Jinny; Wilkin, Terence J.

doi:10.1373/clinchem.2008.103499

Cited by 27 publications

(21 citation statements)

References 30 publications

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“…There are some studies in healthy children on the national level, [8][9][10]20 but their comparability with our results is limited mostly because of either a different age distribution of the sample or due to incomparable laboratory analyses. Pre-analytical (for example, serum vs plasma) and analytical factors (laboratory method) can significantly affect measured concentrations of leptin and adiponectin.…”

Section: Leptin and Adiponectin Values For Children E Erhardt Et Almentioning

confidence: 53%

“…The development of the hormone levels over age were reported by others previously. Murphy et al 20 showed an age-dependant increase of leptin and a decrease of adiponectin in British children between the ages of 5 and 8 years. A Spanish study 22 examining 789 normal-weight children found that the leptin levels rose from 5 to 15 years of age in parallel with total body weight.…”

Section: Leptin and Adiponectin Values For Children E Erhardt Et Almentioning

confidence: 98%

“…It is known that obese individuals have lower adiponectin and higher leptin levels compared with normal-weight individuals. 20 The leptin levels reflect changes in body fat content as the main site of leptin production is the white adipose tissue. Changes in the investigated hormone levels over age in the IDEFICS sample may reflect the age-related changes in body composition (see Nagy et al, 23 this issue), that is, the increase in percent body fat.…”

Section: Leptin and Adiponectin Values For Children E Erhardt Et Almentioning

confidence: 99%

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Reference values for leptin and adiponectin in children below the age of 10 based on the IDEFICS cohort

et al. 2014

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on behalf of the IDEFICS consortium OBJECTIVE: To establish age-and sex-specific reference values for serum leptin and adiponectin in normal-weight 3.0-8.9-year old European children. SUBJECTS AND METHODS: Blood samples for hormone analysis were taken from 1338 children of the IDEFICS (Identification and prevention of Dietary-and lifestyle-induced health Effects in Children and infantS) study cohort. Only normal-weight children aged 3.0-8.9 years were included (n = 539) in our analysis. Using the General Additive Model for Location Scale and Shape, age-and sex-specific percentiles were derived. The influence of under/overweight and obesity on the proposed reference curves based on normal-weight children was investigated in several sensitivity analyses using the sample without obese children (n = 1015) and the whole study sample (n = 1338). RESULTS: There was a negative age trend of adiponectin blood levels and a positive trend of leptin levels in boys and girls. Percentiles derived for girls were generally higher than those obtained for boys. The corresponding age-specific differences of the 97th percentile ranged from − 2.2 to 4.6 μg ml − 1 and from 2.2 to 4.8 ng ml − 1 for adiponectin and leptin, respectively. CONCLUSIONS: According to our knowledge, these are the first reference values of leptin and adiponectin in prepubertal, normal-weight children. The presented adiponectin and leptin reference curves may allow for a more differentiated interpretation of children's hormone levels in epidemiological and clinical studies.

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Section: Leptin and Adiponectin Values For Children E Erhardt Et Almentioning

confidence: 53%

Section: Leptin and Adiponectin Values For Children E Erhardt Et Almentioning

confidence: 98%

Section: Leptin and Adiponectin Values For Children E Erhardt Et Almentioning

confidence: 99%

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Reference values for leptin and adiponectin in children below the age of 10 based on the IDEFICS cohort

et al. 2014

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“…Fasting plasma insulin was higher in girls, even allowing for their BMI and body composition. This might also be explained on the basis of earlier puberty (an insulin-resistant state), or conversely that girls may be intrinsically more insulin resistant (26) . We had expected HDL-cholesterol concentration to be directly related to placental and birth weight.…”

Section: Discussionmentioning

confidence: 99%

Developmental origins of cardiovascular risk in Jamaican children: The Vulnerable Windows Cohort Study

et al. 2010

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Both intra-uterine and early childhood development contribute to the risk of developing CVD in adult life. We therefore evaluated the maternal, placental, fetal, birth, infant and childhood determinants of cardiovascular risk in a cohort of Afro-Jamaican children. The Vulnerable Windows Cohort is a longitudinal survey of 569 mothers and their offspring recruited from the first trimester. The offspring's anthropometry was measured at birth, at 6 weeks, every 3 months to 1 year and then every 6 months. At mean age 11·5 years, fasting blood was sampled for glucose, insulin and lipids. Analyses were confined to 296 women and their offspring who had complete data. Waist circumference (WC) was related to maternal weight and BMI, placental weight and to the size of the offspring in utero, at birth and the rate of growth in childhood (P,0·05). Total cholesterol, TAG and glucose concentrations were unrelated to maternal, placental, fetal, neonatal and childhood measurements. Fasting insulin and homeostasis model assessment of insulin resistance were related to maternal weight and BMI (P,0·05), but not after adjusting for WC. HDL-cholesterol was inversely related to placental and birth weight, and inversely related to weight and BMI throughout childhood (P, 0·001), but not after adjusting for WC. Systolic blood pressure was directly related to maternal weight, child's height, weight and BMI (P, 0·05), but not after adjustment for WC. Systolic blood pressure and fasting glucose concentration were inversely related to birth weight in boys but directly associated in girls. We concluded that maternal anthropometry during pregnancy, fetal size, and childhood growth rate contribute to cardiovascular risk factors in childhood.

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“…Between 5 and 8 years of age, metabolic health appears to improve regardless of BMI, with an increase in leptin and a decrease in adiponectin (37). In fact, adiponectin levels in childhood show a marked reversal of the positive body mass correlations observed during the neonatal period: plasma adiponectin levels at age 5 are inversely correlated with percentage of body fat.…”

Section: Childhood and Pubertymentioning

confidence: 95%

Leptin and adiponectin in the female life course

Lecke¹,

Morsch²,

Spritzer³

2011

Braz J Med Biol Res

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Adipose tissue secretes a variety of adipokines, including leptin and adiponectin, which are involved in endocrine processes regulating glucose and fatty metabolism, energy expenditure, inflammatory response, immunity, cardiovascular function, and reproduction. The present article describes the fluctuations in circulating leptin and adiponectin as well as their patterns of secretion in women from birth to menopause. During pregnancy, leptin and adiponectin seem to act in an autocrine/paracrine fashion in the placenta and adipose tissue, playing a role in the maternal-fetal interface and contributing to glucose metabolism and fetal development. In newborns, adiponectin levels are two to three times higher than in adults. Full-term newborns have significantly higher leptin and adiponectin levels than preterms, whereas small-for-gestational-age infants have lower levels of these adipokines than adequate-for-gestational-age newborns. However, with weight gain, leptin concentrations increase significantly. Children between 5 and 8 years of age experience an increase in leptin and a decrease in adiponectin regardless of body mass index, with a reversal of the newborn pattern for adiponectin: plasma adiponectin levels at age five are inversely correlated with percentage of body fat. In puberty, leptin plays a role in the regulation of menstrual cycles. In adults, it has been suggested that obese individuals exhibit both leptin resistance and decreased serum adiponectin levels. In conclusion, a progressive increase in adiposity throughout life seems to influence the relationship between leptin and adiponectin in women

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Distribution of Adiponectin, Leptin, and Metabolic Correlates of Insulin Resistance: A Longitudinal Study in British Children; 1: Prepuberty (EarlyBird 15)

Cited by 27 publications

References 30 publications

Reference values for leptin and adiponectin in children below the age of 10 based on the IDEFICS cohort

Reference values for leptin and adiponectin in children below the age of 10 based on the IDEFICS cohort

Developmental origins of cardiovascular risk in Jamaican children: The Vulnerable Windows Cohort Study

Leptin and adiponectin in the female life course

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