Distribution of α₁-Antitrypsin Variants in a US White Population

Abstract

A white population from the State of Minnesota of primarily German and Scandinavian heritage was subtyped for α₁-antitrypsin variants using isoelectric focusing. The frequencies of the genes PPM1 (0.724), PI*M2 (0.137) and PI*M3 (0.095) were consistent with those for white populations documented in the literature from Northern Europe. Other genes identified in the study were PI*F, PPI, PPP, PPS and PPZ.

Distribution of Alpha-1-Antitrypsin Phenotypes in Sweden

“…The observed gene frequencies of the M alleles in Sweden were similar to those given for other Caucasian populations [9,10], and the frequencies of the alleles Z and S to those found in Scandinavia [11], A population study from northern Sweden [12] showed lower frequencies of the alleles Z and S than in this material.…”

Polymorphism of Alpha-1-Antitrypsin (Pi) in the Swiss Population Determined by Isoelectric Focusing with an Immobilized pH Gradient

“…Table III pres ents our results com pared with the Pi phenotype distributions reported for other European populations, a United States' white and a Japanese population sample. The frequencies of the comm on genes were com parable to the ones found in other population o f Caucasian origin [Klasen et al, 1977;W eidinger et al, 1982;Böhme et al, 1983;Dykes et al, 1984;Yua s a e ta l., 1984;Thym ann, 1986]. There are only minimal regional differences of allele frequencies in Europe.…”

α1-antitrypsin and survival in hepatocellular carcinoma

“…identified (Cox, 1978;Morse, 1978;Kuhnl & Spielmann, 1979;Buffone et al, 1983;Dykes et al, 1984). The association between a,AT and HCC is complex and intriguing, and may reflect both the pathophysiological role of a,AT (Eriksson, 1985;Garver et al, 1986) and its production by the liver (Glasgow et al, 1982).…”