Distribution of APOE gene variations in the Jordanian population: Association with longevity

Khabour, Omar F.; Abdelhalim, Essa S.

doi:10.1016/j.jksus.2018.08.004

Cited by 4 publications

(2 citation statements)

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“…The most frequently occurring genotype observed was the ε3/ε3 (51.55%) followed by ε2/ε3 (17.39%), ε3/ε4 (15.53%), ε4/ε4 (8.70%) and ε2/ε4 (4.35%). These observed frequencies vary when compared to what is seen in other populations [ 54 , 56 , 57 ]. ApoE*ε4 allele was also least represented in our study population.…”

Section: Discussionmentioning

confidence: 54%

Apolipoprotein E genetic variation, atherogenic index and cardiovascular disease risk assessment in an African population: An analysis of HIV and malaria patients in Ghana

et al. 2023

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Background Apolipoprotein E is involved in lipid transport and clearance of lipoprotein through low-density lipoprotein receptors (LDLR). ApoE variation has been linked to cardiovascular disease (CVD) risk. There are 3 isoforms of ApoE which originate from two non-synonymous single nucleotide polymorphisms denoted as ε2, ε3 and ε4. The ε2 isoform is implicated in higher levels of atherogenic lipoprotein with the ε4 isoform causing LDLR downregulation. This leads to variable effects and differential CVD risk. Malaria and HIV are life-threatening diseases affecting several countries globally especially in sub-Saharan Africa. Parasite and viral activities have been implicated in lipid dysregulation leading to dyslipidaemia. This study examined ApoE variation and CVD risk assessment in malaria and HIV patients. Methods We compared 76 malaria-only, 33 malaria-HIV coinfected, 21-HIV-only and 31 controls from a tertiary health facility in Ghana. Fasting venous blood samples were taken for ApoE genotyping and lipid measurements. Clinical and laboratory data were collected with ApoE genotyping performed using Iplex Gold microarray and PCR-RFLP. Cardiovascular disease risk was calculated using the Framingham BMI and cholesterol risk and Qrisk3 tools. Results The frequency of C/C genotype for rs429358 was 9.32%, whiles T/T genotype for rs7412 was found in 2.48% of all participants. ε3/ε3 was the most distributed ApoE genotype accounting for 51.55% of the total participants whiles ε2/ε2 was found in 2.48% of participants, with 1 in malaria-only and 3 in HIV-only patients. There was a significant association between ε4+ and high TG (OR = 0.20, CI; 0.05–0.73; p = 0.015), whiles ε2+ was significantly associated with higher BMI (OR; 0.24, CI; 0.06–0.87; p = 0.030) and higher Castelli Risk Index II in females (OR = 11.26, CI; 1.37–92.30; p = 0.024). A higher proportion of malaria-only participants had a moderate to high 10-year CVD risk. Conclusion Overall malaria patients seem to have a higher CVD risk though the means through which this occurs may be poorly understood. ε2/ε2 genotypes was observed in our population at a lower frequency. Further studies are vital to determine CVD risk in malaria and how this occurs.

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Section: Discussionmentioning

confidence: 54%

Apolipoprotein E genetic variation, atherogenic index and cardiovascular disease risk assessment in an African population: An analysis of HIV and malaria patients in Ghana

et al. 2023

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“…The ApoEԐ3 variant form has 112 Cysteine and 158 Arginine residues, ApoEԐ4 has only Arginine residues in both positions, and ApoEԐ2 has only Cysteinein both residues 10 . Several studies that evaluated the allelic profile of the population show that the Ԑ3 allele is the most frequent comprising about 70 to 80% of the population, while the Ԑ4 and Ԑ2 alleles correspond to about 10 to 15% and 5 to 10% of the population, respectively [11][12][13][14] .…”

Section: Introductionmentioning

confidence: 99%

Association between alzheimer’s disease and apoe gene genotypic polymorphisms: systematic review and meta-analysis / Associação entre doença de alzheimer e polimorfismos genotipicos do gene apoe: revisão sistemática e metanálise

Pereira¹,

Gonçalves²,

Silva³

et al. 2021

BJDV

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Introduction-Alzheimer's disease (AD) is classified as neurodegenerative, progressive and irreversible and is clinically characterized by a progressive decline in neurological functions. Objective-To evaluate the association among the genotypic variations of the APOE gene with Alzheimer's Disease. Methods-This is a systematic review and metaanalysis, and, according to the inclusion criteria, 59 articles were selected from the PubMed, Latin American and Caribbean Literature in Health Sciences (LILACS) and Scientific databases Electronic Library Online (SciELO) and of this total, 22 contributed data for systematic review and meta-analysis. Statistical tests were performed with the aid of the STATA® 16.0 software, considering the significance limit equal to 5% (pvalue = 0.05). Thus, the DerSimonian-Laird and Mantel Haenszel tests were applied according to heterogeneity, for the evaluation of Odds Ratios (OR). Results-The results showed an association of predisposition to the development of AD, considering the genotypes Ԑ3Ԑ4 and Ԑ4Ԑ4, respectively OR = 2.63 (95% CI = 2.18-318) and OR = 5.37 (95% CI = 3.57-8.08), on the other hand, the genotypes Ԑ2Ԑ3 and Ԑ3Ԑ3, showed

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GenF: A longevity predicting framework to aid public health sectors

Khalid

Rasheed

Qamar

2021

Informatics in Medicine Unlocked

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Distribution of APOE gene variations in the Jordanian population: Association with longevity

Cited by 4 publications

References 52 publications

Apolipoprotein E genetic variation, atherogenic index and cardiovascular disease risk assessment in an African population: An analysis of HIV and malaria patients in Ghana

Apolipoprotein E genetic variation, atherogenic index and cardiovascular disease risk assessment in an African population: An analysis of HIV and malaria patients in Ghana

Association between alzheimer’s disease and apoe gene genotypic polymorphisms: systematic review and meta-analysis / Associação entre doença de alzheimer e polimorfismos genotipicos do gene apoe: revisão sistemática e metanálise

GenF: A longevity predicting framework to aid public health sectors

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