Distribution of Apoptotic Cells and Apoptosis-Related Molecules in the Developing Murine Palatine Rugae.

Amasaki, Hajime; Ogawa, Miyuki; Nagasao, Jun; Mutoh, Ken-ichiro; Ichihara, Nobutsune; Asari, Masao

doi:10.1292/jvms.64.1103

Cited by 6 publications

(3 citation statements)

References 25 publications

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“…Apoptosis has also been demonstrated as a sculptor of development (3), particularly in branching morphogenesis essential for proper development of several organ tissues as the lung, the kidney and the mammary and salivary glands (4,5). Apoptosis is also evident in morphogenesis of craniofacial structures such as the inner ear (6), palatine rugae (7), alveolar bone (8), temporomandibular joint (9) and teeth.…”

Section: Apoptosis In Embryogenesis and Odontogenesismentioning

confidence: 99%

CD 95 mediated apoptosis in embryogenesis: implication in tooth development

Matalová¹,

Setkova²,

Blackburn³

et al. 2006

Orthod Craniofacial Res

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To date studies of apoptotic machinery during tooth development show spatial localization of many of the components together with precise and localized timing of cell death. There is still much to be learned about the regulation and importance of apoptosis in tooth development. Nevertheless, the involvement of apoptotic regulatory mechanisms interplaying with other molecules participates to the cellular cross-talk in developing tissues, which opens possible targeted modulations as suggested, e.g. for future molecular dentistry.

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Section: Apoptosis In Embryogenesis and Odontogenesismentioning

confidence: 99%

CD 95 mediated apoptosis in embryogenesis: implication in tooth development

Matalová¹,

Setkova²,

Blackburn³

et al. 2006

Orthod Craniofacial Res

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“…Whether increased epithelial apoptosis within the primitive palatal rugae as described in the mouse (Tureãková et al 1996;Peterková et al 1998;Amasaki et al 2002;Takanosu et al 2002;) plays a role in palatal ridge formation and elevation, remains to be studied.…”

Section: Epithelium and Mesenchyme Of The Palatal Ridge Primordiamentioning

confidence: 99%

Morphogenesis of Palatal Ridges in the Golden Hamster (Mesocricetus auratus, Rodentia)

Buchtová¹,

Matulová²,

Witter³

et al. 2005

Acta Vet. Brno

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Rugae palatinae (RP) -transversal mucosal ridges of the mammalian palate -are assumed to play a role during closure of the palate in embryos. The aim of this study was to assess the morphogenesis of palatal ridges in the golden hamster (Mesocricetus auratus, Rodentia) by light and scanning electron microscopy. Cell proliferation was detected by immunohistochemical staining of proliferating cell nuclear antigen (PCNA). In the hamster, three to four antemolar and three intermolar ridges were formed. In ED 11.0 (ED -embryonic day) embryos, RP1 and RP3 were at the epithelial thickening stage, RP2 was a primitive ruga in the rostral part of the palatal processes. In the caudal part of the palate, an epithelial placode represented the prospective RP4-RP7. At ED 12.5, the closed secondary palate bore six ridge primordia. Only RP2 protruded distinctly into the oral cavity. At ED 13.0-14.5 and ED15.0-15.5, the mesenchymal core of the antemolar and intermolar ridge primordia, respectively, started to develop. Strikingly, a local increase of proliferation activity does not seem to be the main process involved in palatal ridge formation and elevation. Although the palatal ridge formation and elevation is based on tissue volume enlargement, strikingly, the proliferation activity was higher in the interrugal epithelium than in the ridge primordia. Rather than the epithelial proliferation activity increase, the change in orientation of mitotic spindles of dividing cells seems to be a reason of palatal ridge formation. Oral cavity, proliferation, embryo, foetus, developmentPalatal ridges (rugae palatinae) are more or less transversal mucosal ridges of the hard palate, which are covered by a cornified stratified squamous epithelium. Number and arrangement of the palatal ridges is specific for the respective mammalian species.Palatal ridges have an important function during pre-and postnatal development. They help to transport the food within the oral cavity (Zietzschmann et al. 1943) and take part in grinding the food between tongue and hard palate (Eisentraut 1975). Palatal ridges contain tactile and taste receptors, so they have also a sensory function (Scott and Symons 1967;Luke 1980). In embryos, they are assumed to stiffen and strengthen the palatal processes during formation of the secondary palate (Pourtois 1972;Brinkley and Vickerman 1982;Luke 1984;Bulleit and Zimmerman 1985).Palatal ridge development has been studied mainly in the mouse. Primordia of the rugae palatinae are as well as dental and vestibular laminae derivatives of the odontogenic epithelial zone, an epithelial placode on the oral surface of the developing maxilla that can be recognised in ED 12.0 mouse embryos (Peterková 1985). The development of individual palatal ridges of the mouse starts at ED 13.0.Step by step eight rugal primordia occur. The

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“…Although one previous study has shown the critical movement patterns of palatal shelves by using carbon particle transplantations during in vitro organ cultivation of the palate, the investigation only mentions the palatal fusion mechanism (Chou et al 2004). In addition, cellular events in rugae-forming regions have been studied together with region-specific proliferation and apoptosis patterns in two separate regions designated as the ruga ridge and the inter-rugae (Luke 1984;Amasaki et al 2002Amasaki et al , 2003Takanosu et al 2002). These studies have revealed that the elongation of the palate occurs only in the inter-rugae region.…”

Section: Introductionmentioning

confidence: 99%

Importance of region-specific epithelial rearrangements in mouse rugae development

et al. 2011

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Epithelial appendages on palatal rugae develop during mouse palatogenesis through epithelial thickening and pattern formation. Recently, the patterned formation of nine rugae was observed together with the specific expression patterns of Shh in rodents. However, no crucial evidence was found for a direct association between Shh expression and the distinct structural formation of rugae. In order to reveal possible relationships, we investigated the morphological changes of rugae and expression patterns of Shh directly by in vitro organ culture at embryonic day 13 (E13) for 2 days. To compare and examine the diverse growing aspects of the palate and rugae, we carefully observed the detailed morphogenesis, with cell proliferation of the rugae occurring between E13 and E14.5. After 2 days of cultivation at E13, DiI micro-injections revealed that the middle part of the palate, adjacent to the upper molar-forming region, contributed to the formation of the subsequent structure of rugae by extensive cell rearrangement and proliferation within the epithelium in the preferred anteroposterior direction. The results also defined the intimate relationship between Shh expression and rugae formation.

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Distribution of Apoptotic Cells and Apoptosis-Related Molecules in the Developing Murine Palatine Rugae.

Cited by 6 publications

References 25 publications

CD 95 mediated apoptosis in embryogenesis: implication in tooth development

CD 95 mediated apoptosis in embryogenesis: implication in tooth development

Morphogenesis of Palatal Ridges in the Golden Hamster (Mesocricetus auratus, Rodentia)

Importance of region-specific epithelial rearrangements in mouse rugae development

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