Distribution of Aquaporin-4 channels in hippocampus and prefrontal cortex in mk-801-treated balb/c mice

Ericek, Omer Burak; Akıllıoğlu, Kübra; Şaker, Dilek; Çevik, I. Ethem; Kutlu, Meltem Dönmez; Kara, Samet; Yılmaz, Derviş

doi:10.1080/01913123.2021.2024633

Cited by 5 publications

(1 citation statement)

References 41 publications

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“…Whether larger ventricles in childhood onset schizophrenia lead to reduced intracranial compliance and then influence the glymphatic function remains to be answered. Furthermore, as one of the key elements of the glymphatic system, alterations in AQP4 may be another potential factor that influences CSF circulation in patients with schizophrenia 101 . Further imaging studies on glymphatic function by assessing AQP4 expression, water exchange across BBB and ependymal cells are helpful for providing more insights into the pathophysiology of schizophrenia.…”

Section: Applications In Pediatricsmentioning

confidence: 99%

Glymphatic Imaging in Pediatrics

Li,

Lin,

Liu

et al. 2023

Magnetic Resonance Imaging

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The glymphatic system, which facilitates cerebrospinal fluid (CSF) flow through the brain parenchyma, is important for brain development and waste clearance. Advances in imaging techniques, particularly magnetic resonance imaging, have make it possible to evaluate glymphatic structures and functions in vivo. Recently, several studies have focused on the development and alterations of the glymphatic system in pediatric disorders. This review discusses the development of the glymphatic system, advances of imaging techniques and their applications in pediatric disorders. First, the results of the reviewed studies indicate that the development of the glymphatic system is a long‐lasting process that continues into adulthood. Second, there is a need for improved glymphatic imaging techniques that are non‐invasive and fast to improve suitability for pediatric applications, as some of existing methods use contrast injection and are susceptible to motion artifacts from long scanning times. Several novel techniques are potentially feasible for pediatric patients and may be used in the future. Third, the glymphatic dysfunction is associated with a large number of pediatric disorders, although only a few have recently been investigated. In conclusion, research on the pediatric glymphatic system remains an emerging field. The preliminary applications of glymphatic imaging techniques have provided unique insight into the pathological mechanism of pediatric diseases, but mainly limited in visualization of enlarged perivascular spaces and morphological measurements on CSF volumes. More in‐depth studies on glymphatic functions are required to improve our understanding of the mechanisms underlying brain development and pediatric diseases.Level of Evidence5Technical EfficacyStage 3

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Section: Applications In Pediatricsmentioning

confidence: 99%

Glymphatic Imaging in Pediatrics

Li,

Lin,

Liu

et al. 2023

Magnetic Resonance Imaging

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Aripiprazole combined with nerve growth factor improves cognitive function in mice with schizophrenia model

Lu¹,

Li²,

Kang³

et al. 2023

Neuroscience Letters

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Evidence of Neurovascular Water Exchange and Endothelial Vascular Dysfunction in Schizophrenia: An Exploratory Study

Goldwaser

Wang

Adhikari

et al. 2023

Schizophrenia Bulletin

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Background and Hypothesis Mounting evidence supports cerebrovascular contributions to schizophrenia spectrum disorder (SSD) but with unknown mechanisms. The blood–brain barrier (BBB) is at the nexus of neural-vascular exchanges, tasked with regulating cerebral homeostasis. BBB abnormalities in SSD, if any, are likely more subtle compared to typical neurological insults and imaging measures that assess large molecule BBB leakage in major neurological events may not be sensitive enough to directly examine BBB abnormalities in SSD. Study Design We tested the hypothesis that neurovascular water exchange (Kw) measured by non-invasive diffusion-prepared arterial spin label MRI (n = 27 healthy controls [HC], n = 32 SSD) is impaired in SSD and associated with clinical symptoms. Peripheral vascular endothelial health was examined by brachial artery flow-mediated dilation (n = 44 HC, n = 37 SSD) to examine whether centrally measured Kw is related to endothelial functions. Study Results Whole-brain average Kw was significantly reduced in SSD (P = .007). Exploratory analyses demonstrated neurovascular water exchange reductions in the right parietal lobe, including the supramarginal gyrus (P = .002) and postcentral gyrus (P = .008). Reduced right superior corona radiata (P = .001) and right angular gyrus Kw (P = .006) was associated with negative symptoms. Peripheral endothelial function was also significantly reduced in SSD (P = .0001). Kw in 94% of brain regions in HC positively associated with peripheral endothelial function, which was not observed in SSD, where the correlation was inversed in 52% of brain regions. Conclusions This study provides initial evidence of neurovascular water exchange abnormalities, which appeared clinically associated, especially with negative symptoms, in schizophrenia.

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Distribution of Aquaporin-4 channels in hippocampus and prefrontal cortex in mk-801-treated balb/c mice

Cited by 5 publications

References 41 publications

Glymphatic Imaging in Pediatrics

Glymphatic Imaging in Pediatrics

Aripiprazole combined with nerve growth factor improves cognitive function in mice with schizophrenia model

Evidence of Neurovascular Water Exchange and Endothelial Vascular Dysfunction in Schizophrenia: An Exploratory Study

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