Distribution of axial length in Chinese congenital ectopia lentis patients: a retrospective study

Zhang, Yichi; Jin, Guangming; Cao, Qian; Lin, Junxiong; Lin, Jianqiang; Wang, Yiyao; Poh, Su Ern; Young, Charlotte Aimee; Zheng, Danying

doi:10.1186/s12886-017-0508-1

Cited by 16 publications

(16 citation statements)

References 22 publications

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“…The main topics covered were diagnostics (12%), cardiovascular matters (50%), skeletal matters (22%), ocular matters (9%), other medical aspects (5%) and psychosocial perspectives (2%). Most papers were published in subject‐specific journals, most commonly in heart journals (41%), as shown in Figure .…”

Section: Resultsmentioning

confidence: 99%

“…There were seven studies (2011‐2018), presented in eight papers, on different aspects of ocular manifestations that matched our inclusion criteria (Table ). The topics included macular and optic nerve topography; biometry characteristics, including axial length, aqueous depth, corneal astigmatism, central corneal thickness, lens thickness and corneal curvature .…”

Section: Resultsmentioning

confidence: 99%

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A scoping review presenting a wide variety of research on paediatric and adolescent patients with Marfan syndrome

et al. 2020

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Aim The present study aimed to map and summarise the research on children, aged 0‐18 years, with Marfan syndrome, identify research gaps and point to research agendas. Methods A scoping review was systematically performed by searching multiple databases from January 1996 to April 2019. Primary studies presenting results on at least six individuals aged 0‐18 years with Marfan syndrome, diagnosed according to the Ghent nosology, were selected. Results From 2341 de‐duplicated records, 92 papers were included, mapped and described. Their topics were diagnostics (12%), cardiovascular matters (50%), skeletal matters (22%), ocular matters (9%), other medical aspects (5%) and psychosocial perspectives (2%). Most studies were from Europe and North America and published between 1999 and 2019 in subject‐specific or paediatric journals, while a few were published in genetics journals. All studies had quantitative designs, and very few were multicentre studies. Each study had six to 608 subjects for a total of approximately 5809. Conclusion A wide range of research topics on adolescent and paediatric Marfan syndrome was found, but qualitative studies and a focus on psychosocial matters were lacking. Future investigations addressing noncardiovascular consequences and patient experiences are needed, as well as studies reaffirming or replicating existing intervention study results.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

A scoping review presenting a wide variety of research on paediatric and adolescent patients with Marfan syndrome

et al. 2020

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“…The AL is the most important factor affecting the accuracy of IOL power, and a 1-mm error of measurement can induce an approximate 2.5D refractive error 19 . Previous investigations have shown the AL in the eyes of patients with EL was different from those in normal eyes 20 . However, there have been few studies of the characteristics of the AL in MFS eyes before lens surgery.…”

Section: Discussionmentioning

confidence: 69%

Analysis of axial Length of Marfan Syndrome with Bilateral Ectopia Lentis by Z-scores for Chinese Patients under 20 years Old

Chen¹,

Chen²,

Zhang³

et al. 2020

Preprint

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Purpose: To analyze the axial length (AL) in young patients with Marfan syndrome (MFS) and bilateral ectopia lentis (EL) before the lens surgery. Methods: This study reviewed MFS patients under 20 with bilateral EL from January 2015 to October 2020. The Z-scores were introduced in terms of the number of standard deviations (SD) from the mean of age-matched normative data. Using Z-scores, the distribution of AL and influence factors were evaluated. The correlations between AL and other biometrics were analyzed. Results: We reviewed 183 patients, and enrolled both eyes. The mean age was 8.44 ± 4.69 years old. The mean AL increased from 23.41 ± 1.73 mm under 5 years old to 26.40 ± 2.28 mm in the 16-20 age group, and when plotted, the trend presented a logarithmic curvature. The mean Z-AL score was 1.74 ± 2.68. One-third of eyes had Z-score < 0. The right eye and the eye complicated with megalocornea had larger Z-AL scores. A positive correlation was found between Z-AL and Z-Corneal Curvature Radius (r = 0.265, P < 0.001).Conclusion: Young patents with bilateral EL but small AL should not be excluded from MFS without systematic examination. The age-adjusted Z-score will facilitate further study of the individual variations in AL across different ages.

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“…The AL is the most important factor affecting the accuracy of IOL power, and a 1-mm error of measurement can induce an approximate 2.5-D refractive error [19]. Previous investigations have shown the AL in the eyes of patients with EL is different from that in normal eyes [20]. However, there have been few studies of the characteristics of the AL in young MFS patients before lens surgery.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Axial Length in Young Patients with Marfan Syndrome and Bilateral Ectopia Lentis by Z-Scores

Chen

Zhang

et al. 2021

Ophthalmic Res

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Introduction: Marfan syndrome (MFS) is characterized by ectopia lentis (EL) and elongated axial length (AL). The characteristics of AL in young patients with MFS and bilateral EL before the lens surgery are not fully understood. Methods: This study reviewed MFS patients under 20 years old with bilateral EL from January 2015 to October 2020. The Z-scores were introduced in terms of the number of standard deviations from the mean of age-matched normative data. Using Z-scores, the distribution of AL and influence factors were evaluated. The correlations between AL and other biometrics were analyzed. Results: We reviewed 183 patients and enrolled both eyes. The mean age was 8.44 ± 4.69 years. About 36% of the patients were children under 6 years old. The median AL increased from 23.16 mm under 5 years old to 26.20 mm in the 16–20 age group, and when plotted, the trend presented a logarithmic curvature (R2 = 0.145, p < 0.001). The median Z-AL score was 1.24. One-third of eyes had Z-score <0. About 20% of the patients had AL difference over 1 mm between the right and left eyes, and the right one had longer Z-AL scores (p = 0.013). The eye complicated with megalocornea (10, 7.04%) had larger Z-AL scores (4.72 ± 3.51 vs. 1.10 ± 2.25, p = 0.002). A positive correlation was found between Z-AL and Z-corneal curvature radius (r = 0.265, p < 0.001). Conclusion: Young patients with bilateral EL but small AL should not be excluded from MFS without systematic examination. The age-adjusted Z-score will facilitate further study of the individual variations in AL across different ages.

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Distribution of axial length in Chinese congenital ectopia lentis patients: a retrospective study

Cited by 16 publications

References 22 publications

A scoping review presenting a wide variety of research on paediatric and adolescent patients with Marfan syndrome

A scoping review presenting a wide variety of research on paediatric and adolescent patients with Marfan syndrome

Analysis of axial Length of Marfan Syndrome with Bilateral Ectopia Lentis by Z-scores for Chinese Patients under 20 years Old

Analysis of Axial Length in Young Patients with Marfan Syndrome and Bilateral Ectopia Lentis by Z-Scores

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