Distribution of Blood, Serum Protein and Enzyme Groups among the Fuyuge Speakers of the Goilala Sub-District

Woodfield, D. G.; Scragg, R.F.R.; Blake, N. M.; Kirk, R. L.; McDermid, E. M.

doi:10.1159/000152689

Cited by 18 publications

(5 citation statements)

References 7 publications

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“…Adenylate Kinase Little AK testing has been reported from New Guinea, and so far no variation has been found [Malcolm et al, 1972;Woodfield et al, 1974], In the present surveys, 1 AK 2-1 subject was found among 49 Agarabe tested. Otherwise all were AK 1-1.…”

Section: Malate Dehydrogenasecontrasting

confidence: 45%

Red Cell Antigen, Serum Protein and Red Cell Enzyme Polymorphisms in Eastern Highlanders of New Guinea

Mourant¹,

Tills

Kopeć

et al. 1982

Hum Hered

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A series of 1,187 blood samples from eight population groups in the Eastern Highlands of Papua New Guinea were tested for genetic variation in blood groups, serum proteins and red cell enzyme systems. The populations belonged to the language groups Gahuku-Asarc-Bena Bena, Kamano, Yagaria, Keiagana, Fore, Agarabe, Auyana and Tairora. Polymorphic variation was found in the ABO, MNS, P_1; Rh, Hp, Tf, SEP, 6-PGD, ADA, MDH, and PGM genetic systems. East to West variation was shown in the language groups; the O, S, R₂, and R₀ genes increase in frequency from East to West and the A, R₁, and M genes decrease in the same direction. In the East higher frequencies were found for the D^a antigen, for the PGM²₁ gene and for a PGM second locus variant. The MDH 3 variant was found in all the populations, its highest value being in the Tairora.

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Section: Malate Dehydrogenasecontrasting

confidence: 45%

Red Cell Antigen, Serum Protein and Red Cell Enzyme Polymorphisms in Eastern Highlanders of New Guinea

Mourant¹,

Tills

Kopeć

et al. 1982

Hum Hered

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“…, with f(Pa) in the range 0.25-0.40 and Pc rare or absent; f(PGM:) high (>9); f(ADA2) comparatively high ( > 0.08); MDH3 present at low frequency; and PGM,' and ESDZ variants both present at polymorphic frequencies (Simmons and Booth, 1971;Omoto and Blake, 1972;Howells, 1973;Kirk et al, 1973;Woodfield et al, 1974;Blake and Omoto, 1975;Blake, 1976Blake, , 1978. Although the frequency of the TfDl allele is lower among the Gainj than among most other highland peoples, its frequency is known to vary widely throughout the region (Kirk et al, 1973;Serjeantson et al, 1973;Hazlett et al, 1979).…”

Section: Genetic Resultsmentioning

confidence: 99%

The genetic demography of the Gainj of Papua New Guinea. I. Local differentiation of blood group, red cell enzyme, and serum protein allele frequencies

Wood¹,

Johnson²,

Kirk

et al. 1982

American J Phys Anthropol

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Allele frequencies are reported for 19 blood group, red cell enzyme, and serum protein loci (ABO, Rh, MN, Hb-A, LDH-A, LDH-B, SOD, PGM-1, PGM-2, 6PGD, GPT, ESD, ADA, ACP, PGK, MDH, Alb, Hp, and Tf) determined from 310 blood samples collected among the Gainj, a small population of tribal horticulturalists from highland Papua New Guniea. Fourteen of these loci display genetic variants, and ten of them are sufficiently polymorphic to permit a preliminary analysis of Gainj population structure. Patterns of variation among subdivisions of the population are analyzed using an approach analogous to a multivariate analysis of variance with unbalanced design, and weighted genetic distances are extracted from the results. The distance analysis indicates that patterns of genetic variation within this population reflect the geographical distribution of subdivisions, as well as subdivision size and movement among subdivisions. A parallel analysis of the Gainj and two other tribal groups from highland New Guinea, the Murapin Enga and the Simbai Valley Maring, suggests that the Gainj are both genetically divergent from neighboring populations and internally highly differentiated.

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“…Serum samples were collected as a part of a blood group phenotype survey in PNG over 30 years ago [13,14]. Samples were from three geographically isolated areas of PNG: Tufi, Iruna and Fly River.…”

Section: Methodsmentioning

confidence: 99%

A high incidence of polymorphic CYP2C19 variants in archival blood samples from Papua New Guinea

et al. 2008

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There is considerable inter-ethnic variability in the incidence of CYP2C19 genetic poor metabolisers (var/var). About 3 per cent of Caucasians are CYP2C19 var/var. By contrast, an extremely high incidence (70 per cent) is observed in the Melanesian island of Vanuatu. The colonisation of the Pacific Islands is believed to have involved migration through Papua New Guinea (PNG), and hence a high incidence may also be expected in this population. The reported incidence in PNG was only 36 per cent, however. PNG is a country of extensive ethnic diversity, and the incidence of the CYP2C19 var/var in other regional populations of PNG is currently not established. In this study, restriction fragment length polymorphism-polymerase chain reaction analysis of archival blood serum samples was used to determine the prevalence of the CYP2C19*2 and *3 variant alleles in three different ethnic and geographically isolated populations of PNG. In the largest population studied (Iruna), the frequency of both variant CYP2C19 alleles was high (0.37 and 0.34, respectively). Specifically, the frequency of the CYP2C19*3 allele was significantly higher than in the PNG (East Sepik) population reported previously (0.34 vs 0.16; p <0.0001). In the Iruna population, 48.9 per cent of the samples were homozygous variants for CYP2C19*2 or *3, which although higher was not statistically different from the East Sepik population (36 per cent). The results of this study indicated that other regional populations of PNG also have a relatively high incidence of the CYP2C19 genetic polymorphism compared with Caucasian populations. The high incidence reported in Vanuatu, however, may be due to genetic drift rather than a PNG founder population, as the Vanuatu population is dominated by the CYP2C19*2 allele, with a lower contribution from the *3 allelic variant.

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Distribution of Blood, Serum Protein and Enzyme Groups among the Fuyuge Speakers of the Goilala Sub-District

Cited by 18 publications

References 7 publications

Red Cell Antigen, Serum Protein and Red Cell Enzyme Polymorphisms in Eastern Highlanders of New Guinea

Red Cell Antigen, Serum Protein and Red Cell Enzyme Polymorphisms in Eastern Highlanders of New Guinea

The genetic demography of the Gainj of Papua New Guinea. I. Local differentiation of blood group, red cell enzyme, and serum protein allele frequencies

A high incidence of polymorphic CYP2C19 variants in archival blood samples from Papua New Guinea

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