Distribution of bone mineral density with age and gender in the proximal tibia

Khodadadyan-Klostermann, Cyrus; Seebach, Max von; Taylor, William R.; Duda, Georg N.; Haas, Norbert

doi:10.1016/j.clinbiomech.2003.12.013

Cited by 27 publications

(20 citation statements)

References 25 publications

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“…A reasonable explanation could be that other factors can influence bone health. BMD is primarily influenced by everyday activity level of various body parts (20), hormonal profile (21),and gender and age (22). The present study patients followed a sedentary lifestyle with a rather low level of physical activity at the time of the initial body composition measurement.…”

Section: Discussionmentioning

confidence: 99%

Bone density in patients with late onset Pompe disease

Papadimas¹,

Terzis

Papadopoulos³

et al. 2012

Int J Endocrinol Metab

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BackgroundPompe disease is an inherited metabolic disorder characterized by α-glycosidase deficiency, which leads to lysosomal glycogen accumulation in many different tissues. The infantile form is the most severe with a rapidly fatal outcome, while the late onset form has a greater phenotypic variability, characterized by skeletal muscle dysfunction and early respiratory involvement. Bone mineral density (BMD) has been recently reported to be reduced in many patients with both forms of the disease. Enzyme replacement therapy (ERT) is now available with an undefined, impact on BMD in patients with late onset disease.ObjectivesThe present study aimed to investigate BMD in patients with late onset form of Pompe disease before and after ERT initiation.Patients and MethodsDual x-ray absorptiometry (DEXA) was examined in four newly diagnosed patients with late onset Pompe disease and in four adults under ERT before and after ERT initiation with a treatment duration of 18 to 36 months.ResultsThe initial DEXA showed normal total body BMD z-score in all the patients, while L2-L4 and femoral neck BMD was reduced in three and two patients, respectively. After ERT administration, two patients had an improvement in L2-L4 lumbar spine and one patient in femoral neck BMD z-score with values within normal range.ConclusionsThe results suggested that regional BMD may moderately reduce in some patients with the late onset form of Pompe disease, although profound osteopenia was not observed. The improvement of measurements in L2-L4 and femoral neck BMD z-score in some patients with low pre-treatment values after ERT administration needs to be confirmed in larger scale studies.

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Section: Discussionmentioning

confidence: 99%

Bone density in patients with late onset Pompe disease

Papadimas¹,

Terzis

Papadopoulos³

et al. 2012

Int J Endocrinol Metab

View full text Add to dashboard Cite

show abstract

“…2, the texture features, and especially the Haralick textures, extracted from the raw pixels are noticeably more informative for the age compared to the other tested physiological indicators. This can be explained by the ability of the texture features to measure the radiographic anisotropy of the tibia, which has been associated with mechanical properties of the bone such as the apparent density, collagen concentration, collagen density, and volume fraction [5] and has a significant correlation with age [6,10].…”

Section: Resultsmentioning

confidence: 99%

A computer analysis method for correlating knee X-rays with continuous indicators

Shamir

2011

Int J CARS

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“…The co-occurrence matrix makes it insensitive to changes in luminosity. The radiographic anisotropy of the tibia has been associated with mechanical properties of the bone such as the apparent density, collagen concentration, collagen density and volume fraction (Ding et al 1997), and has a significant correlation with age (Ding et al 2002;Khodadadyan-Klostermann et al 2004).…”

Section: Image Analysis Methodsmentioning

confidence: 99%

Quantitative measurement of human ageing using computer-aided radiographic texture analysis

Shamir¹

2013

Computer Methods in Biomechanics and Biomedical Engineering: Im

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Studying the process of ageing in humans is dependent on methods for quantitative measurement of the physiological differences between younger and older individuals. Although in many cases the chronological age is used as a measurement of ageing, it provides merely a rough approximation of the actual physiological age of a person. Here, we propose a computer method for measuring the physiological age of the human knee by using quantitative analysis of the radiographic Haralick bone texture. Experiments using longitudinal data from the Baltimore Longitudinal Study of Aging show that the radiographic Haralick texture correlates with the chronological age, and that the ageing of the knee as reflected by the tibial anisotropy and measured using the radiographic texture is not linear to the chronological age. The analysis reveals that the bone ages until the person gets to the age of ,40, then stabilises until the age of around 65, from where it continues to age. A period of rapid ageing was also detected around the age of 55. This shows that periods of rapid morphological changes of the knee occur not only during maturation, but also during ageing.

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Distribution of bone mineral density with age and gender in the proximal tibia

Cited by 27 publications

References 25 publications

Bone density in patients with late onset Pompe disease

Bone density in patients with late onset Pompe disease

A computer analysis method for correlating knee X-rays with continuous indicators

Quantitative measurement of human ageing using computer-aided radiographic texture analysis

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