Distribution of certain subgingival microbial species in selected periodontal conditions

Savitt, Eugene D.; Socransky, S. S.

doi:10.1111/j.1600-0765.1984.tb00800.x

Cited by 263 publications

(140 citation statements)

References 34 publications

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“…Two cross-sectional studies reported significance as a function of the number of sites in which A. actinomycetemcomitans was detected, but the numbers of other organisms, such as P. gingivalis, F. nucleatum, P. intermedia, E. corrodens, and spirochetes, were also significantly increased (170,254). These considerations undermine the evidence that A. actinomycetemcomitans is an important periodontopathogen in LJP, let alone EOP.…”

Section: Specific Plaque Hypothesismentioning

confidence: 59%

Periodontal Disease as a Specific, albeit Chronic, Infection: Diagnosis and Treatment

Loesche

Grossman²

2001

Clin Microbiol Rev

413

338

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Periodontal disease is perhaps the most common chronic infection in adults. Evidence has been accumulating for the past 30 years which indicates that almost all forms of periodontal disease are chronic but specific bacterial infections due to the overgrowth in the dental plaque of a finite number of mostly anaerobic species such as Porphyromonas gingivalis, Bacteroides forsythus, and Treponema denticola. The success of traditional debridement procedures and/or antimicrobial agents in improving periodontal health can be associated with the reduction in levels of these anaerobes in the dental plaque. These findings suggest that patients and clinicians have a choice in the treatment of this overgrowth, either a debridement and surgery approach or a debridement and antimicrobial treatment approach. However, the antimicrobial approach, while supported by a wealth of scientific evidence, goes contrary to centuries of dental teaching that states that periodontal disease results from a “dirty mouth.” If periodontal disease is demonstrated to be a risk factor for cardiovascular disease and stroke, it will be a modifiable risk factor since periodontal disease can be prevented and treated. Since the antimicrobial approach may be as effective as a surgical approach in the restoration and maintenance of a periodontally healthy dentition, this would give a cardiac or stroke patient and his or her physician a choice in the implementation of treatment seeking to improve the patient's periodontal condition so as to reduce and/or delay future cardiovascular events

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Section: Specific Plaque Hypothesismentioning

confidence: 59%

Periodontal Disease as a Specific, albeit Chronic, Infection: Diagnosis and Treatment

Loesche

Grossman²

2001

Clin Microbiol Rev

413

338

View full text Add to dashboard Cite

show abstract

“…20 Zambon et al ' were unable to culture P. gingivalis from periodontallyhealthy adults, but 30% proved to be positive by immunofluorescence microscopy. With a DNA probe (detection level lo3 cells), P. gingivalis was found in 20.4 YO and 4 1.8 % of 59 " subgingival " plaque samples from periodontally-healthy children with a Modified Plaque Index of 0 and 1, respectively.…”

Section: T Denticola a N D P Gingivalis In Plaque 409mentioning

confidence: 99%

Prevalence of Treponema denticola and Porphyromonas gingivalis in plaque from periodontally-healthy and periodontally-diseased sites

Wilson¹,

Lopatin²,

Osborne³

et al. 1993

Journal of Medical Microbiology

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Summary. Intracrevicular plaque from periodontally-healthy individuals who had refrained from oral hygiene measures for 24 h prior to sampling, and subgingival plaque from diseased sites of patients with chronic periodontitis were screened by ELISA for the presence of Porph~~omonns gingirdis and Treponema denticola. The samples were also subjected to the PerioScan test to detect the presence of enzymes capable of degrading N-benzoyl-DL-arginine-Z-naphthylamide (BANA). Of the 14 1 samples from periodontally-healthy sites, 73 O h contained T. denticola antigens and 78 * / o P. gingiualis antigens, compared to 43 YO and 59 YO, respectively, in plaque samples from the 159 diseased sites. A positive reaction in the PerioScan test was obtained in 89% of plaque samples from diseased sites and in 60% of those from healthy sites. The correlation between the results of the two assays was poor in the case of intracrevicular plaque from healthy sites. However, with plaque samples from diseased sites, the results of the PerioScan test showed very strong correlation with those obtained with the ELISA, suggesting that the former may be a useful, rapid means of indicating the presence of T. denticola and P. gingicalis in such plaque samples.

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“…Moreover, clinical diagnoses of gingivitis at present are typically based on individual observations and judgment by human examiners, where the results can be difficult to compare between patients and examiners. Furthermore, despite the complexity of oral microbial communities and the suspected polymicrobial nature of chronic oral infections, most population-wide surveys of gingivitisassociated microbiota have been limited to only a few culturable bacteria (for example, the 'red complex' including Porphyromonas gingivalis, Tannerella forsythia and Treponema denticola) (Loe et al, 1965;Savitt and Socransky, 1984;Socransky et al, 1998;Haffajee et al, 2008;Igic et al, 2012;Eick et al, 2013) or have employed a small sampling size (Kistler et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Predictive modeling of gingivitis severity and susceptibility via oral microbiota

Huang

Li²,

Zeng³

et al. 2014

The ISME Journal

124

133

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Predictive modeling of human disease based on the microbiota holds great potential yet remains challenging. Here, 50 adults underwent controlled transitions from naturally occurring gingivitis, to healthy gingivae (baseline), and to experimental gingivitis (EG). In diseased plaque microbiota, 27 bacterial genera changed in relative abundance and functional genes including 33 flagellar biosynthesis-related groups were enriched. Plaque microbiota structure exhibited a continuous gradient along the first principal component, reflecting transition from healthy to diseased states, which correlated with Mazza Gingival Index. We identified two host types with distinct gingivitis sensitivity. Our proposed microbial indices of gingivitis classified host types with 74% reliability, and, when tested on another 41-member cohort, distinguished healthy from diseased individuals with 95% accuracy. Furthermore, the state of the microbiota in naturally occurring gingivitis predicted the microbiota state and severity of subsequent EG (but not the state of the microbiota during the healthy baseline period). Because the effect of disease is greater than interpersonal variation in plaque, in contrast to the gut, plaque microbiota may provide advantages in predictive modeling of oral diseases.

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Distribution of certain subgingival microbial species in selected periodontal conditions

Cited by 263 publications

References 34 publications

Periodontal Disease as a Specific, albeit Chronic, Infection: Diagnosis and Treatment

Periodontal Disease as a Specific, albeit Chronic, Infection: Diagnosis and Treatment

Prevalence of Treponema denticola and Porphyromonas gingivalis in plaque from periodontally-healthy and periodontally-diseased sites

Predictive modeling of gingivitis severity and susceptibility via oral microbiota

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