Distribution of complete blood count constituents in gestational diabetes mellitus

Abstract

Background (Trial Design): The incidence rate of gestational diabetes is high. In the long run, it harms the health of both the mother and child. In order to understand the distribution of hematological cells with gestational diabetes mellitus (GDM), a longitudinal cohort study was conducted from 2012 to 2018. Methods: A longitudinal case control study of 1860 pregnant women was conducted between 2012 and 2018. Data of hematological parameters at 11 time points of gestational stage were obtained from a laboratory database. Repeated measures analysis and independent t-test were used to analyze the effect of the hematological parameters on GDM. Results: The trend of blood cells fluctuated with gestational age in normal controls but was more remarkable in GDM. Compared with the controls, blood neutrophils, lymphocytes, and monocytes augmented in the second trimester but decreased in the third trimester; platelet (PLT) and thrombocytocrit increased throughout the three trimesters, and red blood cell (RBC) was abundant in the last 2 trimesters in GDM. Conclusions: Peripheral blood leukocytes, platelets, and erythrocytes were significantly different during gestation between GDM and normal controls. Inflammation may also be involved in GMD.

Dengue in Pregnancy: A Southeast Asian Perspective

“…Therefore, physiological changes in Han Chinese and SEA women may have similarities. This data is also consistent with other sources that state that women are in a hypercoagulable state in the second trimester [ 20 ].…”

“…For the other articles, one from SEA includes a case report from Singapore [ 26 ]. Research based in Asia consists of that from China [ 20 ] only. Research based on populations outside of Asia was from Mexico [ 17 ], Spain [ 22 ], and the United Kingdom [ 24 ].…”

“…From SEA, an Indonesian article [ 55 ] and the Malaysia guideline on dengue [ 5 ] were used. From Asia, articles used include the Sri Lankan clinical guidelines [ 7 ] and research from China if the population discussed was of Chinese ancestry [ 20 , 62 , 64 ]. Populations outside Asia that were used include England [ 66 ].…”

The Association of Hematological Parameters in Early and Middle Pregnancy with the Risk of Gestational Diabetes Mellitus

“…A longitudinal study among 1860 pregnant Chinese women found approximately equivalent levels in WBC between the GDM and non-GDM groups during gestational weeks 25–28, and then WBC in the GDM group decreased until delivery, whereas WBC levels in the non-GDM group continued to increase during pregnancy and peaked at week 1 postpartum. 17 Another study conducted in Turkey enrolled 269 pregnant women found no significant difference in WBC levels between the GDM and non-GDM group during 24–28 weeks of gestation. 32 However, the mechanism of the slight decrease of WBC in GDM women has not been elucidated, and it may be related to the inflammation and insulin resistance in middle pregnancy.…”

Therapeutic potential and novel formulations of ursolic acid and its derivatives: an updated review

“…With remarkable success, a variety of novel drug delivery systems have been tested in recent years, as indicated in Table 3, aiming to enhance the physicochemical characteristics of UA and support its therapeutic usage. In addition to making hydrophobic medicines more soluble and bioavailable, they also modify drug release 82 . Nano delivery was studied by Manayi et al 46 .…”