Distribution of congenital malformations at birth in a tertiary care hospital in North-Western Rajasthan

Vyas, Ritu; Verma, Susheel; Malu, V. K.

doi:10.18203/2320-1770.ijrcog20164328

Cited by 3 publications

(3 citation statements)

References 9 publications

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“…7,8 Vyas et.al from Kota and Gandhi et.al from Surat both have reported much lower incidence of congenital anomalies at birth i.e 1.23%. 9,10 In our study the maximum number of congenital anomalies was from the musculo skeletal system followed by the central nervous system. Tenali et.al and Bhat et.al have also reported musculoskeletal congenital anomalies as the commonest.…”

Section: Discussionmentioning

confidence: 68%

Spectrum of congenital malformations at birth among neonates in a private medical college in South Rajasthan

Bhatia

2019

Int J Contemp Pediatr

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Background: Congenital anomalies contribute to about 12% neonatal deaths annually .Neonates with multiple congenital malformations pose a very difficult management problem for the treating physician. This study was done to know the incidence, pattern of congenital anomalies and to study various maternal risk factors leading to congenital anomalies which may help us in devising strategies for better patient counseling and management.Methods: Prospective cross sectional study carried out from 1st Jan 2014 to 31st December 2018 in a private medical college in India. Neonates (both live and still born) delivered in our hospital during this period formed the part of study group. All congenital anomalies present were documented and classified according to system involoved.Results: Total number of neonates with congenital anomalies were 90, out of which 73 were live births and 17 were still births. The overall incidence of congenital anomalies was 2.375%. The commonest system affected was musculoskeletal system (27.7%) followed by CNS (24.4%). Among the maternal risk factors studied, increased maternal age, consanguineous marriage, maternal gestational diabetes mellitus were all significant risk factors associated with congenital anomalies.Conclusion: Congenital anomalies are a global health problem. In our study we have documented that multiparity, consanguinity, diabetes mellitus, Pregnancy induced Hypertension (PIH), maternal anemia, maternal malnutrition to be major contributing factors for congenital anomalies. Present study highlighted that musculoskeletal and CNS systems to be the most commonly affected by congenital malformations. Antenatal scans remain an important diagnostic tool in screening for congenital anomalies. A good clinical examination at birth could help in early detection of life threatening congenital malformation thereby improving chances of his or her survival.

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Section: Discussionmentioning

confidence: 68%

Spectrum of congenital malformations at birth among neonates in a private medical college in South Rajasthan

Bhatia

2019

Int J Contemp Pediatr

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“…A 2010 study established the critical mechanisms of teratogensis (Taksande et al, 2010): oxidant tension, vascular disturbances, folate antagonisms, and basic teratogenesis, which is regulated by particular receptors, or enzymes, which induce about 10% of all congenital defects attributable to adverse exposure to the substance (Vyas et al, 2016). Those involve medications, multiple respiratory diseases, and other workplace contamination that can be avoided.…”

Section: Epidemiologymentioning

confidence: 99%

“…The impact of these congenital disabilities and their wisely hierarchical structures was examined in 2016 by Vyas et al (Vyas et al, 2016) in a prospective empirical analysis. Also, 13,614 live / stillbirths were reported by the authors; 167 neonates had congenital malformations.…”

Section: Epidemiologymentioning

confidence: 99%

Study Of Clinically Manifested Congenital Malformations In Live Births

Patel¹,

Potdar²

2020

ijrps

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Cross-sectional study in 4786 live births prospective study of surviving infants born scope and clinical manifestations of congenital malformations. It was noted that a total of 4786 live births, the number of infants with a congenital malformation of 100 stillbirths, infant mortality and child morbidity are significantly detected by the abnormal impact. The number of infant birth defects, due to the advanced diagnostic technology, especially the increase USG prenatal and neonatal period. In the current study, 2753 (57.5%) and 2033 (42.5%), male and female fertility. Congenital male fertility in the baby was observed to be relatively high (68) as compared to comparative female (32) cases, as per the chi-square test (p<0.05). For a prevalence of 27 babies (27 percent), in our study, congenital abnormalities, though 2 instances (2 percent) of low birth weights, 9 (9 percent) of the children were very low birth weights and 16 (27.5 percent), of the normal birth weight.

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Congenital anomalies from a physics perspective. The key role of “manufacturing” volatility

Bois

García‐Roger

Hong

et al. 2020

Physica A: Statistical Mechanics and its Applications

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Genetic and environmental factors are traditionaly seen as the sole causes of congenital anomalies. In this paper we introduce a third possible cause, namely random "manufacturing" discrepancies with respect to "design" values. A clear way to demonstrate the existence of this component is to "shut" the two others and to see whether or not there is remaining variability. Perfect clones raised under well controlled laboratory conditions fulfill the conditions for such a test. Carried out for four different species, the test reveals a variability remainder of the order of 10%-20% in terms of coefficient of variation. As an example, the CV of the volume of E.coli bacteria immediately after binary fission is of the order of 10%. In short, "manufacturing" discrepancies occur randomly, even when no harmful mutation or environmental factors are involved. If the pathway is particularly long or requires exceptional accuracy, output dispersion will be high and may lead to malformations. This effect will be referred to as the dispersion effect. We conjecture that it will be particularly significant when major changes occur; this includes the early phase of embryogenesis or the steps leading from stem cells to differentiated (organ-specific) cells. The dispersion effect not only causes malformations but also innocuous variability. For instance monozygotic (MZ) twins resemble each other but are not strictly identical. It is not uncommon to see only one of the twins of a MZ pair showing a congenital defect (see Appendix A). Not surprisingly, there is a strong connection between congenital defects and infant mortality. In the wake of birth there is a gradual elimination of defective units and this screening accounts for the post-natal fall of infant mortality. For reasons which are not yet fully understood, this fall continues until the age of 10 years. Neither do we understand why, as a function of age, the downward trend of human infant mortality follows a power law with an exponent around 1 (whereas for fish it is about 3, see Bois et al. 2019a). Apart from this trend, post-natal death rates also have humps and peaks associated with various inabilities and defects. In short, infant mortality rates convert the case-by-case and mostly qualitative problem of congenital malformations into a global quantitative effect which, so to say, summarizes and registers what goes wrong in the embryonic phase. Based on the natural assumption that for simple organisms (e.g. rotifers) the manufacturing processes are shorter than for more complex organisms (e.g. mammals), fewer congenital anomalies are expected. Somehow, this feature should be visible on the infant mortality rate. How this conjecture can be tested is outlined in our conclusion.3

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Distribution of congenital malformations at birth in a tertiary care hospital in North-Western Rajasthan

Cited by 3 publications

References 9 publications

Spectrum of congenital malformations at birth among neonates in a private medical college in South Rajasthan

Spectrum of congenital malformations at birth among neonates in a private medical college in South Rajasthan

Study Of Clinically Manifested Congenital Malformations In Live Births

Congenital anomalies from a physics perspective. The key role of “manufacturing” volatility

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