Distribution of coronary atherosclerosis in patients with coronary artery disease

Iwasaki, Kohichiro; Matsumoto, Takeshi; Aono, Hitoshi; Furukawa, Hiroshi; Nagamachi, Keima; Samukawa, M

doi:10.1007/s00380-009-1155-0

Cited by 26 publications

(19 citation statements)

References 21 publications

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“…Capodanno et al [25] investigated the epidemiology and the clinical impact of different anatomical phenotypes of the LM coronary artery, and Iwasaki et al [26] investigated the distribution of coronary atherosclerosis in patients with CAD. Their findings suggested that LM phenotypes are more likely to present with atherosclerotic disease and significant stenosis and are particularly heritable [25,26]. …”

Section: Discussionmentioning

confidence: 99%

Interleukin-6 Receptor rs7529229 T/C Polymorphism Is Associated with Left Main Coronary Artery Disease Phenotype in a Chinese Population

Teng

et al. 2014

IJMS

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Left main coronary artery disease (LMCAD) is a particular severe phenotype of coronary artery disease (CAD) and heritability. Interleukin (IL) may play important roles in the pathogenesis of CAD. Although several single nucleotide polymorphisms (SNPs) identified in IL related genes have been evaluated for their roles in inflammatory diseases and CAD predisposition, the investigations between genetic variants and CAD phenotype are limited. We hypothesized that some of these gene SNPs may contribute to LMCAD phenotype susceptibility compared with more peripheral coronary artery disease (MPCAD). In a hospital-based case-only study, we studied IL-1A rs1800587 C/T, IL-1B rs16944 G/A, IL-6 rs1800796 C/G, IL-6R rs7529229 T/C, IL-8 rs4073 T/A, IL-10 rs1800872 A/C, and IL-10 rs1800896 A/G SNPs in 402 LMCAD patients and 804 MPCAD patients in a Chinese population. Genotyping was done using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) and ligation detection reaction (LDR) method. When the IL-6R rs7529229 TT homozygote genotype was used as the reference group, the CC or TC/CC genotypes were associated with the increased risk for LMCAD (CC vs. TT, adjusted odds ratio(OR) = 1.46, 95% confidence interval (CI) = 1.02–2.11, p = 0.042; CC + TC vs. TT, adjusted OR = 1.31, 95% CI = 1.02–1.69, p = 0.037). None of the other six SNPs achieved any significant differences between LMCAD and MPCAD. The present study suggests that IL-6R rs7529229 T/C functional SNP may contribute to the risk of LMCAD in a Chinese population. However, our results were limited. Validation by a larger study from a more diverse ethnic population is needed.

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Section: Discussionmentioning

confidence: 99%

Interleukin-6 Receptor rs7529229 T/C Polymorphism Is Associated with Left Main Coronary Artery Disease Phenotype in a Chinese Population

Teng

et al. 2014

IJMS

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“…Coronary artery disease is a leading cause of death in developing and developed countries [2,17]. No uniform guidelines exist for the postoperative prevention of thrombotic complications after CABG [18].…”

Section: Discussionmentioning

confidence: 99%

Assessment of platelet function by whole blood impedance aggregometry in coronary artery bypass grafting patients on acetylsalicylic acid treatment may prompt a switch to dual antiplatelet therapy

et al. 2011

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“…Furthermore, Fischer et al [16] reported that 9 of 12 monozygotic twin pairs displayed concordance for LM lesions, whereas only 3 of 12 were concordant for MP lesions [28,29], suggesting genetically involvement. Capodanno et al [30] investigated the epidemiology and the clinical impact of different anatomical phenotypes of the LM coronary artery and Iwasaki et al [31] investigated the distribution of coronary atherosclerosis in patients with CAD. They findings suggested that LM phenotypes are more likely to present with atherosclerotic disease and significant stenosis [30] and are particularly heritable [31].…”

Section: Discussionmentioning

confidence: 99%

The role of common variants of the cholesteryl ester transfer protein gene in left main coronary artery disease

et al. 2011

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BackgroundThe cholesteryl ester transfer protein (CETP) has a central role in the lipid metabolism and therefore may alter the susceptibility to atherosclerosis.MethodsThe DNA of 471 subjects [133 subjects with angiographically documented left main coronary artery disease (LMCAD), 241 subjects with more peripheral coronary artery disease (MPCAD) and 97 subjects self reported healthy (Controls)] was analyzed for the frequency of TaqIB and I405V polymorphisms in the gene coding CETP.ResultsThere is no significant difference in CETP allele frequency or genotype distribution among LMCAD and MPCAD patients although there is statistical difference between LMCAD and Controls (p = 0.001). Specifically, patients with LMCAD and B1B1 genotype of TaqIB polymorphism were more frequent present compared to Controls (33.8% vs 22.9%, respectively). The frequency of B2B2 genotype was 3 times lower in the LMCAD group compared to Controls (10.5% vs 30.2%, respectively). In the LMCAD group the frequency of B1 allele compared to Controls was higher (62% vs 46%, respectively, p = 0.001). The relationship between TaqIB gene polymorphism and the LMCAD was independent of lipid profile, with the exception of apolipoprotein A.ConclusionsThese findings indicate that the TaqIB polymorphism may have potential importance in screening individuals at high risk for developing CAD. However, this polymorphism cannot distinguish between LMCAD and MPCAD. Further prospective investigations in larger populations are required to confirm these findings.

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Distribution of coronary atherosclerosis in patients with coronary artery disease

Cited by 26 publications

References 21 publications

Interleukin-6 Receptor rs7529229 T/C Polymorphism Is Associated with Left Main Coronary Artery Disease Phenotype in a Chinese Population

Interleukin-6 Receptor rs7529229 T/C Polymorphism Is Associated with Left Main Coronary Artery Disease Phenotype in a Chinese Population

Assessment of platelet function by whole blood impedance aggregometry in coronary artery bypass grafting patients on acetylsalicylic acid treatment may prompt a switch to dual antiplatelet therapy

The role of common variants of the cholesteryl ester transfer protein gene in left main coronary artery disease

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