Distribution of CXCR4 and γ-catenin expression pattern in breast cancer subtypes and their relationship to axillary nodal involvement

Sivrikoz, Oya Nermin; Doğanay, Latife; Sivrikoz, Ulaş Kemal; Karaarslan, Serap; Sanal, Salahattin M.

doi:10.5114/pjp.2013.39333

Cited by 10 publications

(5 citation statements)

References 27 publications

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“…Earlier, we reported a correlation between cytoplasmic CXCR4 expression and lymph node metastasis, especially in HER2+ and basal-like triple-negative breast cancer patients, thus supporting the similar observations reported by others as well [20]. Furthermore, Zhang et al have reported more pronounced expression of CXCR4 in basal-like triple-negative subtype than in Luminal A [21].…”

Section: Discussionsupporting

confidence: 91%

Distribution of CXCR4 and tumour-infiltrating lymphocytes in breast cancer subtypes; their relationship with each other, axillary lymph node involvement, and other prognostic indicators

Pehlivan¹,

Sivrikoz²,

Dağ³

et al. 2018

pjp

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We have investigated the distribution of chemokine receptor 4 (CXCR4) and CD8-positive, tumour-infiltrating T lymphocytes (CD8+ TILs) in breast cancer subtypes and explored the relationship between them and the well-established conventional prognostic markers, including axillary lymph node involvement. A total of 250 breast cancer patients were included in the study. The patients were separated into luminal A+B, HER2 enriched/overexpressed (HER2+), and triplenegative, on the basis of their staining characteristics, via conventional staining methods. Immunohistochemical (IHC) staining for CXCR4 and CD8+ TILs were performed on the archival tissues from each patient. With increasing intensity of CXCR4 staining, there was a higher incidence of lymph node metastasis (p < 0.01). Similarly, there was a positive correlation between the primary tumour size, HER2+ subtype, lymphovascular invasion, and axillary lymph node involvement. Dense lymphocytic infiltration was observed in HER2+ and triple-negative patients. No correlation between CD8+ TILs in all sites and breast cancer subtypes was discovered. A reverse correlation was discovered with CD8+ TILs stained only intratumorally and CXCR4 expression. In conclusion, lymph node involvement correlates with higher CXCR4 expression in all breast cancer subtypes. Conversely, no such correlation is found with CD8+ TILs.

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Section: Discussionsupporting

confidence: 91%

Distribution of CXCR4 and tumour-infiltrating lymphocytes in breast cancer subtypes; their relationship with each other, axillary lymph node involvement, and other prognostic indicators

Pehlivan¹,

Sivrikoz²,

Dağ³

et al. 2018

pjp

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“…1a ) ; 2+ = 26–75% of cells; and 3+ = >75% of cells ( Fig. 1b ) [23]. Plakoglobin expression was considered high if the score was 3, and low when score was ≤2.…”

Section: Methodsmentioning

confidence: 99%

Circulating tumor cell clusters-associated gene plakoglobin is a significant prognostic predictor in patients with breast cancer

et al. 2017

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BackgroundCirculating tumor cells (CTCs) are linked to metastatic relapse and are regarded as a prognostic marker for human cancer. High expression of plakoglobin, a cell adhesion protein, within the primary tumor is positively associated with CTC clusters in breast cancer. In this study, we investigated the correlation between plakoglobin expression and survival of breast cancer.MethodsWe evaluated 121 breast cancer patients treated with neoadjuvant chemotherapy. Expression of plakoglobin was identified by immunohistochemical staining in the cell membrane. We also examined the relation between the expression of plakoglobin and E-cadherin, an epithelial–mesenchymal transition (EMT) marker.ResultsPatients with high plakoglobin expression had significantly worse distant-metastasis-free survival (DMFS) (P = 0.016, log rank). Plakoglobin expression had no correlation with pathological complete response rate (P = 0.627). On univariate analysis with respect to distant metastasis, high plakoglobin expression showed worse prognosis than low plakoglobin expression [P = 0.036, hazard ratio (HR) = 3.719]. Multivariate analysis found the same result (P = 0.013, HR = 5.052). In addition, there was a significant relationship between the expression of plakoglobin and E-cadherin (P = 0.023).ConclusionsPlakoglobin expression is an independent prognostic factor in patients with breast cancer, particularly for DMFS, and this is related to EMT.Electronic supplementary materialThe online version of this article (doi:10.1186/s40364-017-0099-2) contains supplementary material, which is available to authorized users.

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“…It is enabled by determination of chemokine receptor 4 (CXCR4) expression. Elevated CXCR4 expression was found in 90% (in HER2-positive breast cancer) to 78.5% of patients (luminal A type of cancer) with metastases to the axillary fossa [33]. Use of tests determining the degree of expression of selected gene panels may also be helpful [34,35].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of biological types of breast cancer and their influence on disease staging and therapeutic management – a single-center study

Nowikiewicz¹,

Chmielowska²,

Andrusewicz³

et al. 2017

pjp

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According to the St. Gallen 2011 consensus, proper qualification of breast cancer patients for treatment requires taking into consideration the division into biological types of neoplasms. The goal of this work was to assess the prevalence of all biological types of breast cancer in the population of Kuyavian-Pomeranian province. We determined the influence of particular types of neoplasms on the degree of disease progression and the choice of therapeutic management. The study was conducted on a group of 2653 patients treated surgically due to malignant breast tumors in the Oncology Centre in Bydgoszcz. In the analyzed clinical material we determined the biological type of cancer as well as other prognostic factors. The most commonly identified types of cancer were luminal B1 type (38.4%) and luminal A type (27.4% of cases), followed by a triple-negative type, luminal B2 type and HER2-positive type (respectively: 11.4%, 10.2%, and 6.9% of patients). Estrogen receptors were present in 81.1% and progesterone receptors in 71.4% of subjects. HER2 overexpression was identified in 17.3% of patients. Routine use of a biology-based division into cancer types influences the choice of anti-cancer treatment. Diagnosis of luminal A type of tumor more commonly than other biological types of cancer coexists with lower clinical and pathological disease staging. It allows for more frequent use of sparing surgical techniques in patients. It also makes systemic neoadjuvant chemotherapy unnecessary in the majority of patients (differences in such cases exhibit statistical significance of p < 0.0001).

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Distribution of CXCR4 and γ-catenin expression pattern in breast cancer subtypes and their relationship to axillary nodal involvement

Cited by 10 publications

References 27 publications

Distribution of CXCR4 and tumour-infiltrating lymphocytes in breast cancer subtypes; their relationship with each other, axillary lymph node involvement, and other prognostic indicators

Distribution of CXCR4 and tumour-infiltrating lymphocytes in breast cancer subtypes; their relationship with each other, axillary lymph node involvement, and other prognostic indicators

Circulating tumor cell clusters-associated gene plakoglobin is a significant prognostic predictor in patients with breast cancer

Prevalence of biological types of breast cancer and their influence on disease staging and therapeutic management – a single-center study

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