Distribution of cyanide in heart blood, peripheral blood and gastric contents in 21 cyanide related fatalities

Rhee, Jongsook; Jung, Jinmi; Yeom, Hyesun; Lee, Hansun; Lee, Sangki; Park, Yoo-Sin; Chung, Heesun

doi:10.1016/j.forsciint.2011.04.014

Cited by 20 publications

(23 citation statements)

References 15 publications

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“…Further, in preserved mice cadavers, cyanide diffusion from gut could possibly be an additional factor. High concentration of cyanide in gut content is usually observed during oral ingestion of cyanide (11). Postmortem production of cyanide in blood, brain, liver, kidney, and uterus and gastric content, with concentrations of toxicological implications, has been reported earlier (7,9,11).…”

Section: S168 Journal Of Forensic Sciencesmentioning

confidence: 99%

“…High concentration of cyanide in gut content is usually observed during oral ingestion of cyanide (11). Postmortem production of cyanide in blood, brain, liver, kidney, and uterus and gastric content, with concentrations of toxicological implications, has been reported earlier (7,9,11). Cyanide biosynthesis in postmortem samples has been attributed to presence of several microorganisms as well, whose growth is arrested at low temperature (39,40).…”

Section: S168 Journal Of Forensic Sciencesmentioning

confidence: 99%

“…Diagnosis of sublethal cyanide poisoning usually relies on measuring cyanide levels in the blood, urine, saliva and gastric lavage, analysis of blood gas and lactate levels, and thiocyanate levels in plasma and urine . Whole blood cyanide level is usually found to correlate with signs and symptoms of cyanide poisoning . 2‐Aminothiazolidine‐4‐carboxylic acid (ATCA), a product of cyanide–cystine reaction, has also been proposed as a reliable marker of cyanide poisoning .…”

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confidence: 99%

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Time‐ and Temperature‐Dependent Changes in Cytochrome c Oxidase Activity and Cyanide Concentration in Excised Mice Organs and Mice Cadavers

Singh

Rao

Yadav

et al. 2014

Journal of Forensic Sciences

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Postmortem stability of cyanide biomarkers is often disputed. We assessed the time and temperature-dependent changes in cytochrome c oxidase (CCO) activity and cyanide concentration in various organs of mice succumbing to cyanide. Immediately after death, excised mice organs and mice cadavers were stored at room temperature (35°C ± 5°C) or in frozen storage (-20°C ± 2°C). At various times after death, CCO activity and cyanide concentrations were measured in excised mice organs or organs removed from mice cadavers. The study revealed that (i) measuring both the biomarkers in mice cadavers was more reliable compared to excised mice organs, (ii) measuring temporal CCO activity and cyanide concentration in vital organs from mice cadavers (room temperature) was reliable up to 24 h, and (iii) CCO activity in the brain and lungs and cyanide concentration in organs from mice cadavers (frozen) were measurable beyond 21 days. This study will be helpful in postmortem determination of cyanide poisoning.

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Section: S168 Journal Of Forensic Sciencesmentioning

confidence: 99%

Section: S168 Journal Of Forensic Sciencesmentioning

confidence: 99%

mentioning

confidence: 99%

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Time‐ and Temperature‐Dependent Changes in Cytochrome c Oxidase Activity and Cyanide Concentration in Excised Mice Organs and Mice Cadavers

Singh

Rao

Yadav

et al. 2014

Journal of Forensic Sciences

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“…Because of this, blood is the preferred tissue for analysis. In a series of 21 cyaniderelated fatalities, blood concentrations ranged from 0.3 to 212.4 mg/L (with colorimetric analysis) (Rhee et al 2011). However, even when there is evidence of intoxication, a large amount of cyanide is likely to remain in the digestive tract (Gettler and Baine 1938;Finck 1969).…”

Section: Disease Genesismentioning

confidence: 99%

Rosaceae Juss.

2012

Toxic Plants of North America

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“…Cyanide is also a hydrolysis product of the nerve gas warfare tabun [13]. Consequently, there is an urgent demand for the development of an efficient, selective, and sensitive methods for cyanide detection and monitoring in aqueous systems, soil, and air, in addition to its possible use in forensics [14].…”

Section: Introductionmentioning

confidence: 99%

Selective colorimetric molecular probe for cyanide ion detection in aqueous solution

et al. 2018

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5-Nitro-2-hydroxybenzaldehyde (1) demonstrated to be a sensitive, and a selective molecular probe for cyanide ion (CN-) in aqueous media. In acetonitrile, compound 1 shows sensitivity and selectivity for cyanide, acetate and fluoride, in comparison to other investigated anions using both visual and spectroscopic means. In aqueous solution, the color becomes intense yellow upon addition of cyanide, while acetate showed this effect to a much lower extent. Significant spectral changes were also detected with the appearance of two new absorption bands at 358 and 387 nm. This was accompanied by concomitant intensity decrease for the band at 314 nm. Fluoride, dihydrogen phosphate, chloride, bromide, perchlorate, and azide showed negligible color and spectral changes for the probe in aqueous solutions. On the other hand, hydrogen sulfate caused fainting of the yellow color and gave a spectrum similar to that of the sensor in polar aprotic solvents. The cyanide ion was detected at micro molar levels in aqueous solutions with a stoichiometry of 1:1 for CN: probe in acetonitrile as the solvent. Cyanide, hydroxide, acetate, fluoride and dihydrogen phosphate showed identical changes to color and spectra, indicating a hydrogen bonding and a deprotonation mechanism.

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Distribution of cyanide in heart blood, peripheral blood and gastric contents in 21 cyanide related fatalities

Cited by 20 publications

References 15 publications

Time‐ and Temperature‐Dependent Changes in Cytochrome c Oxidase Activity and Cyanide Concentration in Excised Mice Organs and Mice Cadavers

Time‐ and Temperature‐Dependent Changes in Cytochrome c Oxidase Activity and Cyanide Concentration in Excised Mice Organs and Mice Cadavers

Rosaceae Juss.

Selective colorimetric molecular probe for cyanide ion detection in aqueous solution

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