Distribution of cyclooxygenase-1, cyclooxygenase-2, and cytosolic phospholipase A2 in the luteal phase human endometrium and ovary

Stavréus-Evers, Anneli; Koraen, Linn; Scott, Jennifer E; Zhang, Pu; Westlund, Pär

doi:10.1016/j.fertnstert.2004.06.057

Cited by 30 publications

(25 citation statements)

References 30 publications

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“…Relative abundance of transcripts for prolactin receptor and mucin became lower in mifepristone-treated endometrium on days 4 and 6 respectively after ovulation, compared with control endometrium. These factors are known to be regulated in endometrium by progesterone (Salamonsen & Woolley 1996, Aplin et al 1998, Nayak et al 1998, Kim et al 1999, Marions & Gemzell-Danielsson 1999, Tseng & Mazella 1999, Milne & Jobbour 2003, Lalitkumar et al 2005a, 2005b, Stavreus-Evers et al 2005, Critchley et al 2006, Goff et al 2006, Slayden & Brenner 2006, Makino et al 2007. It may be conjectured that significant changes in the expression of these factors are involved in endometrial hostility in mifepristonetreated endometrium.…”

Section: Discussionmentioning

confidence: 99%

Effect of low-dose mifepristone administration on day 2 after ovulation on transcript profiles in implantation-stage endometrium of rhesus monkeys

Ghosh¹,

Sharkey²,

Charnock-Jones³

et al. 2009

Reproduction

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Progesterone is essential for endometrial receptivity in primates. In studies previously performed using global gene profiling based on microarray technology, attempts have been made to identify changes in gene expression between early luteal-phase and mid-luteal-phase endometria. However, the issue of the putative impact of preimplantation embryo-derived signal in the process of endometrial receptivity was missing in the previous studies. In the present study, an attempt has been made to delineate the transcripts profile in implantation-stage endometrium under combinatorial regulation of progesterone and embryo-derived signal in the rhesus monkey. To this effect, we have compared transcript profiles for 409 known genes between control receptive stage (nZ13), and mifepristone-induced desynchronized and non-receptive stage (nZ12) monkey endometrial samples collected on days 4 (nZ12) and 6 (nZ13) after ovulation from mated, potential conception cycles, using cDNA arrays containing sequence-verified clones. Statistical analysis of correlation of estimated transcript abundance between arrays and qRT-PCR for nine selected gene products yielded significant (P!0.05) concordance. Of 409 genes, a total of 40 gene transcripts were seen to be affected, nine gene transcripts in endometrial samples were found to progressively increase between days 4 and 6 following mifepristone treatment, while an additional five genes showed differential expression profile depending on the day after treatment. Additionally, different sets of 12 and 14 gene products showed changes in days 4 and 6 post-ovulation samples respectively. A new cohort of 28 gene products in implantation-stage endometrium was seen to be affected by luteal-phase mifepristone.

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Section: Discussionmentioning

confidence: 99%

Effect of low-dose mifepristone administration on day 2 after ovulation on transcript profiles in implantation-stage endometrium of rhesus monkeys

Ghosh¹,

Sharkey²,

Charnock-Jones³

et al. 2009

Reproduction

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“…Therefore, it is important to know how different markers of implantation correlate with each other. Several studies have demonstrated correlation between pinopode appearance and expression of integrin α v β 3 [43], osteopontin [44], LIF and LIF receptor [45], HB-EGF [46], glycodelin [47], progesterone receptors [48], antioxidant enzyme glutaredoxin [49] and cyclooxygenases 1 and 2 [50] in the same endometrial tissue samples. These observations are consistent with an important role of the cytokines, growth factors, and other molecules in the implantation process and reveal interesting spatio-temporal aspects of the expression of some of these.…”

Section: Molecular and Structural Markers Of Endometrial Receptivitymentioning

confidence: 99%

Uterine receptivity to human embryonic implantation: Histology, biomarkers, and transcriptomics

Aghajanova¹,

Hamilton²,

Giudice³

2008

Seminars in Cell & Developmental Biology

140

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Embryonic implantation is a dynamic process of paracrine interactions between the maternal compartment and the conceptus and involves a receptive endometrium and a developmentally competent blastocyst. Herein, we review histology, clinical approaches, and the promise of transcriptomics in elucidating mechanisms underlying implantation and development of biomarkers of uterine receptivity -with an eye to diagnose and treat implantation-based disorders of miscarriage, fetal growth restriction, pre-eclampsia, and infertility.Keywords human implantation; endometrium; microarray; blastocyst Challenges and approaches in studying the process of human implantation Clinical implicationsSuccessful embryo implantation is a crucial event in natural and assisted human reproduction. Blastocyst implantation is a dynamic process, involving embryo apposition, attachment to the maternal endometrial epithelium, and invasion into the endometrial stroma [1]. With in vitro fertilization (IVF), implantation failure can occur due to several factors [2], including embryonic defects such as chromosomal abnormalities, which are the most common cause of implantation failure [3,4]. Another widely acknowledged barrier to successful blastocyst implantation and, therefore, successful treatment of infertile women with implantation failure, is an inappropriately developed endometrium. It is well established that embryos cannot implant in a poorly matured endometrium [5], and this may be responsible for low implantation rates with transfer of "good quality" embryos. The success of embryonic implantation further relies upon cross-talk between the embryo and a receptive endometrium [5]. Optimization of IVF results are important for many reasons, and achieving optimal implantation is even more important in the setting of single embryo transfer, a common practice aimed to avoid multiple pregnancies.Corresponding author: Linda C. Giudice, MD, PhD, MSc, Professor and Chair, Department of Obstetrics, Gynecology and Reproductive Sciences, The Robert B. Jaffe, MD Endowed Professor in the Reproductive Sciences, University of California, San Francisco, 505 Parnassus Ave., M1496, Box 0132, San Francisco, CA 94143-0132, Tel: +1 4154762564, Fax: +1 415476181, giudice@obgyn.ucsf.edu. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. The implantation window and challenges of studying it NIH Public AccessThe endometrium is receptive to blastocyst implantation during a spatially and temporally restricted "window", when the luminal epithelium is favorable for blastocyst implantation even in the absence of an implanting ...

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“…311 Several studies have shown misregulation of COX-2 in disorders that lead to impaired fertility. 312,313 Stavreus-Evers et al 304 have observed intense staining of cytosolic PLA 2 in the luminal epithelium during the luteal phase when pinopods were present. However, there was a considerable variation between women suggesting the need for cPLA 2 to be maintained at a minimal level.…”

Section: J Prostaglandinsmentioning

confidence: 97%

“…303 Treatment with mifepristone impairs glandular and luminal epithelial function and endometrial receptivity. 303,304 The critical role of cyclo-oxygenase has been demonstrated by gene ablation studies. 305,306 Targeted ablation of the prostaglandin metabolizing enzyme, COX-2, has been reported to block decidualization.…”

Section: J Prostaglandinsmentioning

confidence: 99%

Endometrial receptivity: Clinical assessment in relation to fertility, infertility, and antifertility

Makker

Singh

2006

Med. Res. Rev.

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Fertility in humans and other mammalian species depends absolutely on synchronous events that render the developing blastocyst and the receiving uterus competent for implantation. Endometrial receptivity is defined as the period during which the endometrial epithelium acquires functional, but transient, ovarian steroid-dependent status supportive to blastocyst acceptance and implantation. Once inside the uterus, the blastocyst is surrounded by an intact luminal epithelium, which is considered to act as barrier to its attachment, except for this short period of high endometrial receptivity to blastocyst signal(s). Its transport and permeability properties, in conjunction with cellular action of the endometrium and the embryo, have been suggested to influence creation and maintenance of informational and nutritional status of uterine luminal milieu. This period, also termed as the 'window of implantation,' is limited to days 20-24 of menstrual cycle in humans. However, establishment of endometrial receptivity is still a biological mystery that remains unsolved despite marked advances in our understanding of endometrial physiology following extensive research associated with its development and function. This review deals with various structural, biochemical, and molecular events in the endometrium coordinated within the implantation window that constitute essential elements in the repertoire that signifies endometrial receptivity and is aimed to achieve a better understanding of its relationship to fertility, infertility, and for the development of targeted antifertility agents for human use and welfare.

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Distribution of cyclooxygenase-1, cyclooxygenase-2, and cytosolic phospholipase A2 in the luteal phase human endometrium and ovary

Cited by 30 publications

References 30 publications

Effect of low-dose mifepristone administration on day 2 after ovulation on transcript profiles in implantation-stage endometrium of rhesus monkeys

Effect of low-dose mifepristone administration on day 2 after ovulation on transcript profiles in implantation-stage endometrium of rhesus monkeys

Uterine receptivity to human embryonic implantation: Histology, biomarkers, and transcriptomics

Endometrial receptivity: Clinical assessment in relation to fertility, infertility, and antifertility

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