Distribution of Duffy Phenotypes among Plasmodium vivax Infections in Sudan

Albsheer, Musab M. Ali; Pestana, Kareen; Ahmed, Salah; Elfaki, Mohammed Mohieldien Abbas; Gamil, Eiman; Ahmed, Salma; Ibrahim, Muntaser E.; Musa, Ahmed; Lo, Eugenia; Hamid, Muzamil Mahdi Abdel

doi:10.3390/genes10060437

Cited by 19 publications

(38 citation statements)

References 25 publications

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“…In New Halfa, despite a smaller sample size, 7.5% (7/93) of the febrile patients was P. vivax-positive and Duffy-negatives accounted for 14.3% (1/7) of these infections (Table 2). Across the country, there has been an increase in P. vivax detection and reports in recent years (Albsheer et al, 2019) and our findings indicated that the infection rate in Duffy-negative individuals varies among study sites.…”

Section: Contrasting Proportion Of Duffy-negatives and P Vivax Prevalencesupporting

confidence: 52%

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Contrasting epidemiology and genetic variation of Plasmodium vivax infecting Duffy-negative individuals across Africa

Russo

Pestana

et al. 2021

International Journal of Infectious Diseases

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Section: Contrasting Proportion Of Duffy-negatives and P Vivax Prevalencesupporting

confidence: 52%

“…* Duffy-§ Conventional PCR of genes PvCOI and PvDBP 1. 2 Pf-Pv co-infections; 2 Duffy-Ag available only among Plasmodium spp pos;…”

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confidence: 99%

Contrasting epidemiology and genetic variation of Plasmodium vivax infecting Duffy-negative individuals across Africa

Russo

Pestana

et al. 2021

International Journal of Infectious Diseases

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“…Study quality was assessed using the JBI Critical Appraisal Tool (Table S2 ). Eighteen studies 18 , 19 , 21 , 23 , 25 – 29 , 32 , 34 – 39 , 41 , 42 were high-quality, while nine 17 , 20 , 22 , 24 , 30 , 31 , 33 , 40 , 43 were of moderate quality.…”

Section: Resultsmentioning

confidence: 98%

“…Three studies 20 , 21 , 31 were conducted in South America (2/27, 7.4%) and Asia (1/27, 3.7%). Of the 24 African studies, six were conducted in East Africa (Ethiopia 28 , 43 , Madagascar 25 , 29 , Kenya 40 , and Ethiopia 41 ), seven in Mid Africa (Democratic Republic of Congo 19 , Cameroon 22 , 23 , 32 , 33 , 39 , Angola, and Equatorial Guinea 30 ), seven in West Africa (Mauritania 24 , 42 , Nigeria 36 , 37 , Senegal 34 , Mali 35 , and Benin 38 ), two in North Africa (Sudan 17 , 18 ), one in North and East Africa (Ethiopia and Sudan 26 ), and one in Ethiopia/Botswana/Sudan 27 . Twenty-two articles were cross-sectional studies (22/27, 81.5%), two were case-controls 12 , 40 , and one was a cohort study 35 .…”

Section: Resultsmentioning

confidence: 99%

Prevalence and risk of Plasmodium vivax infection among Duffy-negative individuals: a systematic review and meta-analysis

Wilairatana

Masangkay

Kotepui

et al. 2022

Sci Rep

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A better understanding of the occurrence and risk of Plasmodium vivax infection among Duffy-negative individuals is required to guide further research on these infections across Africa. To address this, we used a meta-analysis approach to investigate the prevalence of P. vivax infection among Duffy-negative individuals and assessed the risk of infection in these individuals when compared with Duffy-positive individuals. This study was registered with The International Prospective Register of Systematic Reviews website (ID: CRD42021240202) and followed Preferred Reporting Items for Systematic review and Meta-Analyses guidelines. Literature searches were conducted using medical subject headings to retrieve relevant studies in Medline, Web of Science, and Scopus, from February 22, 2021 to January 31, 2022. Selected studies were methodologically evaluated using the Joanna Briggs Institute (JBI) Critical Appraisal Tools to assess the quality of cross-sectional, case–control, and cohort studies. The pooled prevalence of P. vivax infection among Duffy-negative individuals and the odds ratio (OR) of infection among these individuals when compared with Duffy-positive individuals was estimated using a random-effects model. Results from individual studies were represented in forest plots. Heterogeneity among studies was assessed using Cochrane Q and I2 statistics. We also performed subgroup analysis of patient demographics and other relevant variables. Publication bias among studies was assessed using funnel plot asymmetry and the Egger’s test. Of 1593 retrieved articles, 27 met eligibility criteria and were included for analysis. Of these, 24 (88.9%) reported P. vivax infection among Duffy-negative individuals in Africa, including Cameroon, Ethiopia, Sudan, Botswana, Nigeria, Madagascar, Angola, Benin, Kenya, Mali, Mauritania, Democratic Republic of the Congo, and Senegal; while three reported occurrences in South America (Brazil) and Asia (Iran). Among studies, 11 reported that all P. vivax infection cases occurred in Duffy-negative individuals (100%). Also, a meta-analysis on 14 studies showed that the pooled prevalence of P. vivax infection among Duffy-negative individuals was 25% (95% confidence interval (CI) − 3%–53%, I2 = 99.96%). A meta-analysis of 11 studies demonstrated a decreased odds of P. vivax infection among Duffy-negative individuals (p = 0.009, pooled OR 0.46, 95% CI 0.26–0.82, I2 = 80.8%). We confirmed that P. vivax infected Duffy-negative individuals over a wide prevalence range from 0 to 100% depending on geographical area. Future investigations on P. vivax infection in these individuals must determine if Duffy-negativity remains a protective factor for P. vivax infection.

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“…In Sudan, most cases of malaria are caused by P. falciparum but in recent years there has been an increase in P. vivax detection and reports [33]. The proportion of Duffy-negative was 20% (77/384) among febrile patients (Figure 1).…”

Section: Resultsmentioning

confidence: 99%

Contrasting Epidemiology and Genetic Variation of <em>Plasmodium vivax</em> Infecting Duffy Negatives across Africa

Lo¹,

Russo²,

Pestana³

et al. 2020

Preprint

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Recent studies indicated that Plasmodium vivax can infect Duffy-negative individuals, but the varied diagnostic and methodological approaches have limited our ability to characterize P. vivax across Africa. Here, we utilized a standardized approach to compare epidemiological and genetic attributes of P. vivax from Botswana, Ethiopia, and Sudan, where Duffy-positive and Duffy-negative individuals coexist. Among 1,215 febrile patients, the proportions of Duffy negativity range from 20-36% in East Africa to 84% in Southern Africa. Considerable differences were observed in P. vivax prevalence among Duffy-negative populations ranging from averaged 9.2% in Sudan to 86% in Botswana. P. vivax parasite density in Duffy-negative infections is significantly lower than in Duffy-positive infections. Phylogenetic analyses of 229 PvDBP sequences indicated that Duffy-negative P. vivax were not monophyletic but occurred in multiple well-supported clades, suggesting independent origins. Duffy-negative Africans are clearly not resistant to P. vivax and the public health significance should no longer be neglected.

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Distribution of Duffy Phenotypes among Plasmodium vivax Infections in Sudan

Cited by 19 publications

References 25 publications

Contrasting epidemiology and genetic variation of Plasmodium vivax infecting Duffy-negative individuals across Africa

Contrasting epidemiology and genetic variation of Plasmodium vivax infecting Duffy-negative individuals across Africa

Prevalence and risk of Plasmodium vivax infection among Duffy-negative individuals: a systematic review and meta-analysis

Contrasting Epidemiology and Genetic Variation of <em>Plasmodium vivax</em> Infecting Duffy Negatives across Africa

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