Distribution of endocrine cells in the digestive tract of Alligator sinensis during the active and hibernating period

Wang, Huan; Zhang, Shengzhou; Zhou, Naizhen; Wang, Chaolin; Wu, Xiaobing

doi:10.1016/j.tice.2014.06.005

Cited by 5 publications

(9 citation statements)

References 22 publications

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“…Many studies have shown that VIP can be produced in neuronal and various peripheral tissues (Gomariz, Leceta, Garrido, Garrido, & Delgado, ; Lamperti, Rosen, & Villa‐Komaroff, ; Liu et al., ; Nam et al., ; Wang, & Conlon, ; Wang, Zhang, Zhou, Wang, & Wu, ; You, Silsby, Farris, Foster, and El Halawani, ). VIP mRNA tissue‐specific expression in turkey analyzed by Northern blots indicated that VIP is expressed in hypothalamus, small intestine, large intestine, uterus, and oviduct (You et al., ).…”

Section: Introductionmentioning

confidence: 99%

“…() have isolated VIP from the stomach of American alligator by using the radioimmunoassay method, and Wang et al. () have detected VIP immunoreactive cells in the stomach of Chinese alligator by the immunohistochemical method. Studies indicated that the expression level of VIP changed remarkably to enable animals to adapt to different living conditions.…”

Section: Introductionmentioning

confidence: 99%

“…Many studies have shown that VIP can be produced in neuronal and various peripheral tissues (Gomariz, Leceta, Garrido, Garrido, & Delgado, 1994;Lamperti, Rosen, & Villa-Komaroff, 1991;Liu et al, 2014;Nam et al, 2009;Wang, & Conlon, 1993;Wang, Zhang, Zhou, Wang, & Wu, 2014;You, Silsby, Farris, Foster, and El Halawani, 1995).…”

Section: Introductionmentioning

confidence: 99%

“…There were few reports about the expression profiles of VIP in reptiles. Wang et al (1993) have isolated VIP from the stomach of American alligator by using the radioimmunoassay method, and Wang et al (2014) have detected VIP immunoreactive cells in the stomach of Chinese alligator by the immunohistochemical method.…”

Section: Introductionmentioning

confidence: 99%

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Molecular characterization and tissue expression profiles of prepro-vasoactive intestinal peptide in the Chinese alligator (Alligator sinensis) during the active and hibernating periods

et al. 2017

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The Chinese alligator (Alligator sinensis), a freshwater crocodilian endemic to China, is one of the most endangered crocodilian species; up to this date, very little is known about the endocrine regulation of its metabolic activities during different physiological states. In this study, we characterized the structure of the prepro-vasoactive intestinal peptide in Chinese alligator (prepro-caVIP) for the first time and examined its expression profiles in various tissues during the active and hibernating periods. The prepro-caVIP cDNA consists of a 221-bp 5'-untranslated region (UTR), a 606-bp complete coding region (CDS), and a 312-bp 3'-UTR, which encodes the 201-amino acid prepro-caVIP containing a 28-amino acid vasoactive intestinal peptide (VIP) and a 27-amino acid PHI (peptide histidine isoleucine). Multiple alignment analysis showed that VIP shares 100% identity with the given birds, reptiles, and African clawed frog, and 89% identity with mammals, 96% with fishes. Real-time quantitative PCR showed that the prepro-caVIP is widely expressed in all the examined tissues, and the expression level is significantly higher in small intestine, stomach, pancreas, lung, and skeletal muscle, whereas lower in heart, liver, spleen, kidney, ovary, and oviduct. During hibernation, the expression level of caVIP was significantly decreased in small intestine (P < 0.01), pancreas, and skeletal muscle (P < 0.05), whereas significantly increased in liver, spleen, and lung (P < 0.01). The wide distribution of caVIP and its differential expression changes in various tissues during hibernation implicated that it might play multiple effects in Chinese alligator and participate in the physiological adaptation of various organs in a paracrine and/or neurocrine manner.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Molecular characterization and tissue expression profiles of prepro-vasoactive intestinal peptide in the Chinese alligator (Alligator sinensis) during the active and hibernating periods

et al. 2017

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“…Somatostatin (SS), a cyclic tetradecapeptide with an inhibitory role on the release of growth hormone, was first isolated in ovine hypothalamic extracts (Brazeau et al, ). Many subsequent studies have demonstrated that SS is widely distributed in the central nervous system and various peripheral organs where it acts as both a neurotransmitter/neuromodulator and a hormone to regulate various physiological processes such as neuromodulation, cell secretion, smooth muscle contractility, nutrient absorption, and cell growth (Patel, ; Alponti et al, ; Wang et al, ). The brain SS plays a central role in the regulation of feed, water and salt intake in rats, baboons and sheep (Lotter et al, ; Sunagawa et al, ; Stengel et al, ).…”

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confidence: 99%

Immunohistochemical Localization of Somatostatin in the Brain of Chinese Alligator Alligator sinensis

Wang

Zhang

et al. 2016

The Anatomical Record

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In this study, the regional distribution and histological localization of somatostatin (SS) immunoreactive (IR) perikarya and fibers was investigated for the first time in the brain of adult Chinese alligator by immunohistochemical method. The results showed SS-IR perikarya and fibers were widely distributed in various parts of the brain except for olfactory bulbs. In the telencephalon, SS-IR perikarya were predominantly located in the cellular layer and deep plexiform layer of dorsomedial and medial cortex, less in the dorsal and lateral cortex, while SS-IR fibers were found in all layers of the cerebral cortex. SS-IR perikarya and fibers were also detected in the dorsal ventricular ridge, hippocampus cortex, accessory olfactory bulb nuclearus, lenticular nucleus, and caudate nucleus. In the diencephalon, SS-IR perikarya and fibers were mainly present in supraoptic nucleus, paraventricular nucleus of hypothalamus, recessus infundibular nucleus, median eminence, the pineal gland and pituitary gland, in which the IR-fibers were abundant, appearing dot-shaped and varicosity-like. In the mesencephalon, they were present in tectum cortex, ependyma of cerebral aqueduct and the periaqueductal grey matter. Additionally, they were also detected in Purkinje's cellular layer of cerebellum, in the reticularis nucleus and raphe nucleus of medulla oblongata. The distribution pattern of SS-IR perikarya and fibers in the brain of Chinese alligator is generally similar to that reported in other reptiles, but also has some specific features. The wide distribution indicated that SS might be a neurotransmitter or neuromodulator which acts on many kinds of target cells with a wide range of physiological functions. Anat Rec, 300:507-519, 2017. © 2016 Wiley Periodicals, Inc.

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The effect of hibernation on the morphological structure and expression of creatine kinase in the intestine of Pelodiscus sinensis

Pan,

Luo,

Wang

et al. 2024

Aquaculture Reports

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Distribution of endocrine cells in the digestive tract of Alligator sinensis during the active and hibernating period

Cited by 5 publications

References 22 publications

Molecular characterization and tissue expression profiles of prepro-vasoactive intestinal peptide in the Chinese alligator (Alligator sinensis) during the active and hibernating periods

Molecular characterization and tissue expression profiles of prepro-vasoactive intestinal peptide in the Chinese alligator (Alligator sinensis) during the active and hibernating periods

Immunohistochemical Localization of Somatostatin in the Brain of Chinese Alligator Alligator sinensis

The effect of hibernation on the morphological structure and expression of creatine kinase in the intestine of Pelodiscus sinensis

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