Distribution of ESBL-producing enterobacteria associated to community-acquired monomicrobial urinary tract infections and antimicrobial susceptibility trends over a 9-year period

Dias, Vanessa Cordeiro; Silva, Vânia Lúcia da; Firmo, Eduarda de Oliveira; Bastos, Lucas Quinet de Andrade; Bastos, André Netto; Bastos, Ricardo Villela; Diniz, Cláudio Galuppo

doi:10.1179/1973947812y.0000000006

Cited by 5 publications

(13 citation statements)

References 17 publications

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“…According to other studies in Brazil, K. pneumoniae retains relative susceptibility to fluoroquinolones, as shown in this study, and only TMP/SMX and nitrofurantoin were not good options for treatment of UTIs. The profile found in the literature for E. aerogenes is similar to that found in our study, although the literature data indicate a decreased susceptibility to TMP/SMX 9,11,19 .…”

Section: Discussionsupporting

confidence: 90%

“…The percentage reported in the literature varied from 0.2% to 3.5% 11 , which is close to the value of 3.0% among Gram-negative tested between 2010 and 2011, in this study. Although the most frequently isolated bacterium that produces ESBL is Klebsiella spp.…”

Section: Discussionsupporting

confidence: 89%

“…In the one Brazilian study to date 11 about ESBL-producing Enterobacteriaceae in community-acquired UTIs, which evaluated 78,964 urine cultures in Juiz de Fora, State of Minas Gerais, Southeastern of Brazil, from 2001 to 2009, detected a frequency of 0.66% (n = 512) over nine years in the majority of patients older than 65 years (female, 52.6% and male, 48.1%), which is similarly to the results of this study. The percentage reported in the literature varied from 0.2% to 3.5% 11 , which is close to the value of 3.0% among Gram-negative tested between 2010 and 2011, in this study.…”

Section: Discussionmentioning

confidence: 99%

“…The study by DIAS et al 11 evaluated the temporal trend of resistance among ESBL-producing bacteria and showed a peak of occurrence in 2005 (2000-2009) for all antibiotics close to 80% (amikacin, ciprofloxacin, gentamicin, nitrofurantoin, TMP/SMX and imipenem) and a second peak in 2008 (ciprofloxacin and TMP/SMX were close to 80% and nitrofurantoin was close to 40%).…”

Section: Discussionmentioning

confidence: 99%

“…The susceptibility of E. coli in 10 Brazilian studies of community-acquired UTIs showed that only TMP/SMX, cephalothin and norfloxacin presented < 80% susceptibility 1,2,4,9,10,11,19,20,25,26 . In addition to nitrofurantoin, to which P. mirabilis presents intrinsic resistance, TMP/SMX and cephalothin were not good options for treatment of UTIs.…”

Section: Discussionmentioning

confidence: 99%

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Susceptibility to Antibiotics in Urinary Tract Infections in a Secondary Care Setting From 2005-2006 and 2010-2011, in São Paulo, Brazil: Data From 11,943 Urine Cultures

Miranda

Oliveira

Roque

et al. 2014

Rev. Inst. Med. trop. S. Paulo

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Introduction: Urinary tract infection (UTI) has a high incidence and recurrence, therefore, treatment is empirical in the majority of cases. Objectives: The aim of this study was to analyze the urine cultures performed at a secondary hospital, during two periods, 2005-2006 and 2010-2011, and to estimate the microbial resistance. Patients and methods: We analyzed 11,943 aerobic urine cultures according to basic demographic data and susceptibility to antibiotics in accordance with the Clinical and Laboratory Standards Institute (CLSI) for Vitek 1 and 2. Results: Most of our cohort consisted of young adult females that were seen at the Emergency Department. E. coli was the most frequent (70.2%) among the 75 species isolated. Resistance of all isolates was ≥ 20% for trimethoprim/sulfamethoxazole (TMP/SMX), norfloxacin, nitrofurantoin, cefazolin and nalidixic acid. Although E. coli was more susceptible (resistance ≥ 20% for TMP/SMX and nalidixic acid) among all of the isolates, when classified by the number and percentage of antibiotic resistance. Global resistance to fluoroquinolones was approximately 12%. Risk factors for E. coli were female gender and an age less than 65 years. Men and patients older than 65 years of age, presented more resistant isolates. Extended spectrum beta-lactamases (ESBL) were identified in 173 out of 5,722 Gram-negative isolates (3.0%) between 2010 and 2011. Conclusion: E. coli was the most frequent microbe isolated in the urine cultures analyzed in this study. There was a significant evolution of bacterial resistance between the two periods studied. In particular, the rise of bacterial resistance to fluoroquinolones was concerning.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Susceptibility to Antibiotics in Urinary Tract Infections in a Secondary Care Setting From 2005-2006 and 2010-2011, in São Paulo, Brazil: Data From 11,943 Urine Cultures

Miranda

Oliveira

Roque

et al. 2014

Rev. Inst. Med. trop. S. Paulo

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Decreased antibiotic susceptibility of Enterobacteriaceae causing community-acquired urinary tract infections in French Amazonia

Baizet¹,

Ouar-Epelboin

Walter

et al. 2019

Médecine et Maladies Infectieuses

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A 10 year surveillance for antimicrobial susceptibility of Escherichia coli and Klebsiella pneumoniae in community- and hospital-associated intra-abdominal infections in China

Yang

Zhang

Wang

et al. 2013

Journal of Medical Microbiology

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The objective of this study was to investigate the susceptibility of hospital-associated (HA) and community-associated (CA) Escherichia coli and Klebsiella pneumoniae isolated from patients with intra-abdominal infections (IAIs) in China. From 2002 to 2011, the minimum inhibitory concentrations (MICs) of 12 antibiotics against 3074 E. coli and 1025 K. pneumoniae from 23 centres located in 16 cities were determined by the broth microdilution method. During the 10 year study period, ertapenem, imipenem, amikacin and piperacillin-tazobactam retained high and stable activity against E. coli and K. pneumoniae isolates regardless of whether their source was HA or CA and regardless of their extended-spectrum beta-lactamase (ESBL) production. However, the susceptibility of E. coli to cephalosporins and ampicillin-sulbactam decreased dramatically during the 10 years, especially for the CA isolates. Fluoroquinolones showed low activity against E. coli. During the whole study period, the ESBL rates for E. coli isolates from IAIs increased from 36

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Distribution of ESBL-producing enterobacteria associated to community-acquired monomicrobial urinary tract infections and antimicrobial susceptibility trends over a 9-year period

Cited by 5 publications

References 17 publications

Susceptibility to Antibiotics in Urinary Tract Infections in a Secondary Care Setting From 2005-2006 and 2010-2011, in São Paulo, Brazil: Data From 11,943 Urine Cultures

Susceptibility to Antibiotics in Urinary Tract Infections in a Secondary Care Setting From 2005-2006 and 2010-2011, in São Paulo, Brazil: Data From 11,943 Urine Cultures

Decreased antibiotic susceptibility of Enterobacteriaceae causing community-acquired urinary tract infections in French Amazonia

A 10 year surveillance for antimicrobial susceptibility of Escherichia coli and Klebsiella pneumoniae in community- and hospital-associated intra-abdominal infections in China

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