Distribution of estrogen receptor 2 mRNAs (Esr2a and Esr2b) in the brain and pituitary of the sea bass (Dicentrarchus labrax)

Muriach, Borja; Carrillo, Manuel; Zanuy, Silvia; Cerdá‐Reverter, José Miguel

doi:10.1016/j.brainres.2008.02.053

Cited by 36 publications

(25 citation statements)

References 61 publications

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“…This result is consistent with the reports of Anglade et al (1994) and Muriach et al (2008) that ER expression was observed in the forebrain and midbrain areas of rainbow trout, Oncorhynchus mykiss, and European sea bass, Dicentrarchus labrax. Our results suggests that, in males, the forebrain and midbrain are also targets for estrogen, even though these parts of brain have thus far not been regarded as being deeply related to brain functions of male fish.…”

Section: Discussionsupporting

confidence: 93%

Expression levels of sex hormone receptors in brains of Japanese medaka, <I>Oryzias latipes</I> (Actinopterygii: Beloniformes: Adrianichthyidae)

Ngamniyom¹,

Sasayama²

2011

Acta Icth et Piscat

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Background. In teleost fishes, the brain is the target organ for sex steroid hormones. The actions of sex steroid hormones are mediated by their receptors and play an important role in the regulation of endocrine function in the brain. Japanese medaka, Oryzias latipes, is a species widely used in many fields of experimental biology, including neurobiology. In this study, we examined the mRNA expression levels of androgen and estrogen receptors in medaka brains. Materials and methods. The brains of adult fish were separated into three parts (forebrain, midbrain and hindbrain). The expression levels of androgen receptor (AR) and estrogen receptor (ER) β from each part of the brain were determined using a semi-quantitative RT-PCR analysis.Results. AR and ERβ levels in males were higher in the forebrain and midbrain than in the hindbrain. In females, AR and ERβ levels were higher in the forebrain than in the midbrain and hindbrain. AR levels in the forebrain and midbrain of males were higher than those of females. Conversely, there was no difference in ERβ level between males and females. Conclusion. These data on hormone receptors provide the foundation for understanding the molecular basis of AR and ERβ mRNA expression levels in medaka brains. In addition, our results suggest that, in Japanese medaka, AR, but not ERβ, expression may exhibit sexual dimorphisms between males and females in the forebrains and midbrains.

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Section: Discussionsupporting

confidence: 93%

Expression levels of sex hormone receptors in brains of Japanese medaka, <I>Oryzias latipes</I> (Actinopterygii: Beloniformes: Adrianichthyidae)

Ngamniyom¹,

Sasayama²

2011

Acta Icth et Piscat

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“…Estrogens play a pivotal role in the development and maintenance of normal sexual and reproductive functions (Heldring et al, 2007;Muriach et al, 2008). The biological action of estrogens is manifested through two high-affinity estrogen receptors, estrogen receptor alpha and estrogen receptor beta, which belong to the family of the transcription factors, the nuclear receptor super family, and are expressed at different levels in target cells (Greene et al, 1986;Kuiper et al, 1996;Gruber et al, 2004;Tean-Sempere et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Differential expression profiling of estrogen receptor in the ovaries of two egg duck (Anas platyrhynchos) breeds

Wu¹,

Xiao²,

Liang³

et al. 2014

CZECH J ANIM SCI

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AbstrAct:In the present study, quantitative real-time PCR was employed to investigate expression profiling and expression difference of ESR1 and ESR2 in ovaries of Shaoxing duck and Jingjiang duck during three laying stages. Results showed the expression levels of ESR1 and ESR2 in ovaries were increased from the age of the first egg to the age of 500 days in both duck breeds. The expression of ESR1 in Shaoxing duck was lower than that in Jingjiang duck for the age of the first egg and of 180 days, and for the age of 500 days it was higher in Shaoxing duck than in Jingjiang duck. The ESR2 showed converse expression profiling in the two duck breeds. The results suggest that ESR1 and ESR2 mediate the process of egg laying in ducks, and that ESR2 may play a more important role for the ovary during egg-laying stages and may be closely related to the laying performance of the ducks.

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“…The specificity of action of steroid hormone receptors is due to specificity of the receptor to both its ligand and its DNA response element as well as the spatial and temporal expression of the steroid hormone receptor itself. The distribution of androgen and estrogen receptors in the brain has been studied in several teleost species including goldfish, the oyster toadfish, zebrafish, midshipman, sea bass and Atlantic croaker (androgen receptor: Fine et al, 1996;Gelinas and Callard, 1997;Forlano et al, 2009;estrogen receptors: Menuet et al, 2002;Hawkins et al, 2005;Forlano et al, 2005;Muriach et al, 2008). The neural distribution of the progesterone receptor has been studied in zebrafish, although only a few brain regions are described (Hanna et al, 2010).…”

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confidence: 99%

Distribution of sex steroid hormone receptors in the brain of an African cichlid fish, Astatotilapia burtoni

Munchrath

Hofmann

2010

J of Comparative Neurology

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Sex steroid hormones released from the gonads play an important role in mediating social behavior across all vertebrates. Many effects of these gonadal hormones are mediated by nuclear steroid hormone receptors, which are crucial for integration in the brain of external (e.g., social) signals with internal physiological cues to produce an appropriate behavioral output. The African cichlid fish Astatotilapia burtoni presents an attractive model system for the study of how internal cues and external social signals are integrated in the brain as males display robust plasticity in the form of two distinct, yet reversible, behavioral and physiological phenotypes depending on the social environment. In order to better understand where sex steroid hormones act to regulate social behavior in this species, we have determined the distribution of the androgen receptor, estrogen receptor alpha, estrogen receptor beta, and progesterone receptor mRNA and protein throughout the telencephalon and diencephalon and some mesencephalic structures of A. burtoni. All steroid hormone receptors were found in key brain regions known to modulate social behavior in other vertebrates including the proposed teleost homologs of the mammalian amygdalar complex, hippocampus, striatum, preoptic area, anterior hypothalamus, ventromedial hypothalamus, and ventral tegmental area. Overall, there is high concordance of mRNA and protein labeling. Our results significantly extend our understanding of sex steroid pathways in the cichlid brain and support the important role of nuclear sex steroid hormone receptors in modulating social behaviors in teleosts and across vertebrates.

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Distribution of estrogen receptor 2 mRNAs (Esr2a and Esr2b) in the brain and pituitary of the sea bass (Dicentrarchus labrax)

Cited by 36 publications

References 61 publications

Expression levels of sex hormone receptors in brains of Japanese medaka, <I>Oryzias latipes</I> (Actinopterygii: Beloniformes: Adrianichthyidae)

Expression levels of sex hormone receptors in brains of Japanese medaka, <I>Oryzias latipes</I> (Actinopterygii: Beloniformes: Adrianichthyidae)

Differential expression profiling of estrogen receptor in the ovaries of two egg duck (Anas platyrhynchos) breeds

Distribution of sex steroid hormone receptors in the brain of an African cichlid fish, Astatotilapia burtoni

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