Distribution of Etoposide-Loaded Hydrophilic Albumin Microspheres in Mice

Abstract

Hydrophilic albumin microspheres of etoposide were prepared by the emulsion polymerization technique using glutaraldehyde as the cross-linking agent. The microspheres prepared had a mean diameter of 1.5 pm. The microspheres were injected into mice by the intravenous route. In all, 12 mice were selected for the study, out of which 10 were given the drug-loaded microspheres and 2 were kept as solvent control. The mice were sacr@ced afer 24 hr and the accumulation of drug was determined in lungs, liver, and kidney.

Development and <i>in-vitro</i> Evaluation of a Topical Drug Delivery System Containing Betamethazone Loaded Ethyl Cellulose Nanospheres

“…The specimens were air dried before examination with an electron microscope. The electron microscopic view of nanospheres containing betamethazone is shown in Fig 1. In vitro release of drug loaded nanospheres before incorporating into cream base [12][13] A quantity of nanospheres equivalent to 20mg of drug from each batch was placed in a 250 ml conical flask and to it 20ml ethanol and 80 ml phosphate buffer pH 7.4 were added. The flask was kept in a shaker incubator with the shaker oscillating at 20/min at 37 o C. 5ml of drug release medium was withdrawn at various time intervals over a 24 h period.…”