1976
DOI: 10.1016/0002-9610(76)90347-0
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Distribution of gastrin in canine, cat, and human digestive organs

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Cited by 4 publications
(3 citation statements)
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“…A possible explanation for the lower levels of amidated CCK seen in the rat bowel in our studies when compared to others include the location of the bowel chosen since CCK content decreases in distal portions of the small bowel [ 9,17,35]. We identified amidated gastrin molecular forms (G17, G17II, G34 and G34II) in the rat proximal duodenum as reported previously by others [22,23]. To our surprise our data indicated the virtual absence of amidated CCK in the rat proximal duodenum.…”
Section: Discussionsupporting
confidence: 82%
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“…A possible explanation for the lower levels of amidated CCK seen in the rat bowel in our studies when compared to others include the location of the bowel chosen since CCK content decreases in distal portions of the small bowel [ 9,17,35]. We identified amidated gastrin molecular forms (G17, G17II, G34 and G34II) in the rat proximal duodenum as reported previously by others [22,23]. To our surprise our data indicated the virtual absence of amidated CCK in the rat proximal duodenum.…”
Section: Discussionsupporting
confidence: 82%
“…The crucial importance of the amidation reaction that converts glycine-extended peptides into amidated peptides is illustrated by the observation that deamidated forms of gastrin and CCK have mark-edly reduced potency in biological assays when compared to their corresponding amidated forms [19][20][21]. The molecular forms of fully processed carboxylterminally amidated gastrin and its glycine-extended post-translational processing intermediates have been well characterized in the gastric antrum and amidated G34 and G17 have been localized in the duodenum of a variety of species [22,23 ]. portions of mammalian intestine [6,9,[24][25][26][27][28][29][30][31][32][33] and although CCK-gly is felt to be released after a meal [34] the molecular forms of intestinal CCK-gly and G-gly have yet to be determined.…”
Section: Discussionmentioning
confidence: 99%
“…However, few studies on the dog pyloric region have been reported (Tobe et al, 1976). In different species, three types of glandular cells are associated with the mucosa of the pyloric antrum: mucous, endocrine, and parietal cells.…”
Section: Introductionmentioning
confidence: 99%