2021
DOI: 10.1080/17435390.2021.1966116
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Distribution of gold nanoparticles into the brain: a systematic review and meta-analysis

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Cited by 13 publications
(5 citation statements)
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“…A meta-analysis of 36 preclinical studies reported that only 0.06% ID/g of i.v. injected AuNPs in mice were taken up into the brain . In contrast, we achieved a 4000–6000-fold higher concentration of 177 Lu-AuNPs (225–359% ID/g) in GBM tumors in NRG mice when administered by CED (Figure C).…”
Section: Discussionmentioning
confidence: 84%
See 1 more Smart Citation
“…A meta-analysis of 36 preclinical studies reported that only 0.06% ID/g of i.v. injected AuNPs in mice were taken up into the brain . In contrast, we achieved a 4000–6000-fold higher concentration of 177 Lu-AuNPs (225–359% ID/g) in GBM tumors in NRG mice when administered by CED (Figure C).…”
Section: Discussionmentioning
confidence: 84%
“…injected AuNPs in mice were taken up into the brain. 37 In contrast, we achieved a 4000−6000-fold higher concentration of 177 Lu-AuNPs (225−359% ID/g) in GBM tumors in NRG mice when administered by CED (Figure 1C). Moreover, the BBB may pose a barrier to redistribution of 177 Lu-AuNPs from the brain to peripheral organs outside the brain.…”
Section: ■ Discussionmentioning
confidence: 85%
“…Severe combined immune-deficient (Scid) mice with intra-cranial U87 human gliomas were treated with 13 nm AuNps conjugated with siRNA, and the AuNPs were observed to cross the leaky blood-tumor barrier but not the BBB in normal brain [863]. A recent review of nearly 40 studies on the use of AuNPs for brain delivery showed an average brain uptake of 0.06%ID/g [864], which is very low and could be explained on the basis of AuNPs residing in the brain blood volume. AuNPs were hypothesized to cross the BBB via calcium or potassium channels [865].…”
Section: Metallic Nanoparticlesmentioning
confidence: 99%
“…Severe combined immune-deficient (Scid) mice with intra-cranial U87 human gliomas were treated with 13 nm AuNps conjugated with siRNA, and the AuNPs were observed to cross the leaky blood-tumor barrier but not the BBB in normal brain [863]. A recent review of nearly 40 studies on the use of AuNPs for brain delivery showed an average brain uptake of 0.06%ID/g [864], which is very low and could be explained on the basis of AuNPs residing in the brain blood volume. AuNPs were hypothesized to cross the BBB via calcium or potassium channels [865].…”
Section: Metallic Nanoparticlesmentioning
confidence: 99%