Distribution of HCV Genotypes in the Populations of Inmates in Polish Prison Potulice and Patients Hospitalised in Bydgoszcz

Background and Objectives: Hepatitis C is a dangerous viral infection, which is the important cause of chronic liver diseases such as fibrosis, cirrhosis, and hepatocellular carcinoma. The hepatitis C virus (HCV) has six major genotype of HCV identified for which are different in prevalence, carcinogenicity, persistency, and response to the treatment. Identification of HCV genotype and viral load are main factors for planning of the treat and prediction of response. There has not been any study regarding the viral load and genotype distribution of HCV in our area and this study was done to evaluate risk factors, viral load, and genotype of HCV among prisoners in East Iran. Methods: In a cross-sectional study, 2,995 prisoners across the South Khorasan province were screened for the anti-HCV antibody by ELISA method. A total of 38 prisoners with positive results were selected for further evaluation. Demographic data as well as predisposing factors were obtained from the records. A total of 5 ml of venous blood was taken and after RNA extraction, viral load genotype and HCV were identified by using the commercial Real Time PCR and PCR method, respectively.

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“…Parallel to our result, in Tyczyno's study on Poland's prisoners, genotype 3a was the most common genotype (30).…”

Section: Discussionsupporting

confidence: 87%

Assessing the Hepatitis C Genotype in Prisoners Infected with HCV in South Khorasan- 2014

2018

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“…Tyczyno et al compared the HCV genotyping performed on Polish prisoners and hospital patients, and found that HCV genotype 3 prevailed in the prisoners (60.1%) and genotype 1 in patients at large (79.6%). This distinction is most probably due to the fact that genotype 3 is more frequent in PWID [ 45 ]. In Estonia, the following distribution of genotypes was documented among hospital patients: genotype 1b was found in 32% of the patients, 3a was found in 20%, 2a in 12%, and 1a/b (double infection) in 28% [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

Hepatitis C seropositivity among newly incarcerated prisoners in Estonia: data analysis of electronic health records from 2014 to 2015

et al. 2018

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BackgroundHepatitis C virus (HCV) infection is a widespread problem in prisons. The present study aimed to assess the prevalence of HCV seropositivity, HCV genotypes, factors associated with HCV seropositivity in newly incarcerated prisoners and to report experiences of treatment with pegylated interferon/ribavirin for HCV-positive inmates.MethodsPatient data were extracted from the Estonian prison medical information system (Vanglate meditsiiniline infosüsteem) databases.ResultsAmong 1845 prisoners newly incarcerated from January 2014 to January 2015, the overall prevalence of HCV was 56.3% (95% CI: 54 to 59), and 25.5% (95% CI: 23.5 to 27.6%) had HIV (39.0% had neither). The all-inclusive HCV testing strategy identified 37.7% more HCV infected prisoners than the risk-based (drug use history, HIV status) case finding. Factors associated with HCV seropositivity included history of drug use (aOR 6.51 95%CI 5.12–8.28), HIV co-infection (aOR 2.56 95%CI 1.92–3.43), previous incarceration (aOR 3.61 95%CI 2.48–4.04), and increasing age. The main HCV genotypes were 3a (n = 172, 44.4%) and 1b (n = 135, 35.2%). Twenty-five prisoners received HCV treatment: 60% (n = 15) were cured, 16% (n = 4) relapsed (3 with genotype 3a, one with 1b), and 12% (n = 3) were unresponsive (all with genotype 3a).ConclusionsHCV seropositivity rate is high and HCV tretment rate is very low in Estonian prisons. Optimizing case finding and scaling up treatment is critical to addressing the health needs of prisoners and meeting public health goals.

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“…A higher prevalence of HCV genotype 6 has been reported in IDUs in Taiwan [ 7 , 15 ]. Some studies have shown a higher frequency of genotype 3 in prisoners [ 13 , 14 ]. In the general population, genotype 3 is predominant in Thailand, Malaysia, India, and Pakistan [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Genotype distribution and treatment response among incarcerated drug-dependent patients with chronic hepatitis C infection

et al. 2018

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The prevalence of hepatitis C virus (HCV) infection is disproportionately high among prisoners, especially among those who are drug-dependent. However, current screening and treatment recommendations are inconsistent for this population, and appropriate care is not reliably provided. To address these problems, the present study aimed to identify unique characteristics and clinical manifestations of incarcerated patients with HCV infection. We included incarcerated patients who received treatment with pegylated-interferon combined with ribavirin at Mackay Memorial Hospital in Taitung and were serving sentences at either the Taiyuan Skill Training Institute or the Yanwan Training Institute. HCV genotypes 1 (41.4%), 3 (25.9%), and 6 (24.1%) were the most prevalent in the incarcerated patients. During the study period, we analyzed treatment response among 58 incarcerated patients and compared obtained results with treatment response among 52 patients who were living in the community. Higher sustained virological response rate was observed among patients with incarceration and HCV genotype other than 1. The odds ratios (corresponding 95% confidence intervals) for incarceration and genotype 1 were 2.75 (1.06–7.11) and 0.37 (0.14–0.99), respectively. Better treatment compliance among incarcerated patients might partially explain these results. The results of this study suggest that treatment of prisoners with HCV infection is feasible and effective. More appropriate and timely methods are needed to prevent HCV transmission among injection drug users inside prisons.

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Distribution of HCV Genotypes in the Populations of Inmates in Polish Prison Potulice and Patients Hospitalised in Bydgoszcz

Cited by 8 publications

References 23 publications

Assessing the Hepatitis C Genotype in Prisoners Infected with HCV in South Khorasan- 2014

Assessing the Hepatitis C Genotype in Prisoners Infected with HCV in South Khorasan- 2014

Hepatitis C seropositivity among newly incarcerated prisoners in Estonia: data analysis of electronic health records from 2014 to 2015

Genotype distribution and treatment response among incarcerated drug-dependent patients with chronic hepatitis C infection

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