Distribution of hepatitis <scp>C</scp> virus genotypes in <scp>C</scp>hinese patients with chronic hepatitis <scp>C</scp>: Correlation with patients’ characteristics and clinical parameters

Dong, Zhi Xia; Zhou, Hui; Wang, Jianhua; Xiang, Xiaojun; Zhuang, Yan; Guo, Si Min; Gui, Hong Lian; Zhao, Gang; Tang, Wei; Wang, Hui; Xie, Qing

doi:10.1111/j.1751-2980.2012.00636.x

Cited by 17 publications

(13 citation statements)

References 25 publications

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“…With no effective vaccine or post-exposure prophylaxis for HCV treatment, limiting transmission is a primary strategy for the prevention and control of HCV epidemics. Importantly, epidemiological surveillance of HCV transmission routes is instrumental in tracking the dynamics of viral changes in various epidemiological settings [32–34]. In this study, we report the genotype differences between two time periods, 2004-2007 and 2008-2011, in one of China’s HCV epicenters, Guangdong Province.…”

Section: Discussionmentioning

confidence: 96%

Increased prevalence of hepatitis C virus subtype 6a in China: a comparison between 2004–2007 and 2008–2011

Xiao

Xiong

et al. 2014

Arch Virol

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Different hepatitis C virus (HCV) genotypes exhibit differences in disease pathogenesis and progression, as well as disease outcomes and response to therapy. Tracking the change of HCV genotypes in various epidemiological settings is critical for both disease surveillance and the development of improved antiviral treatment. Here, we tracked the changes in the prevalence of the HCV genotypes in China between 2004-2007 and 2008-2011. HCV-RNA-positive sera were collected from volunteer blood donors during the period 2008-2011. The genotypes were determined by phylogenic analysis using the NS5B and E1 sequences. Geographical and demographic distribution patterns related to the HCV genotypes obtained in 2008-2011 were compared with our previous study, which recorded data in the period 2004-2007. Pearson chi-square test and t-test were used to statistically analyze the results. In 2008-2011, HCV subtypes 1b and 6a were detected in 43.8 % (184/420) and 34.3 % (144/420), respectively. The male/female ratio was found to be higher for HCV genotype 6 than for genotypes 1 and 2. When compared with the period of 2004-2007, although no significant difference was found in gender or age for genotypes 1, 2, 3 and 6, the subtype 6a frequency was significantly increased from 11 % to 26.5 % in the blood donors from outside of Guangdong Province in 2008-2011. A pattern of increase in HCV subtype 6a was found in blood donors outside of Guangdong Province, indicating that HCV subtype 6a has rapidly spread from Guangdong to other regions of China over the past 10 years.Electronic supplementary materialThe online version of this article (doi:10.1007/s00705-014-2185-1) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 96%

Increased prevalence of hepatitis C virus subtype 6a in China: a comparison between 2004–2007 and 2008–2011

Xiao

Xiong

et al. 2014

Arch Virol

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“…The distribution of HCV genotypes in relation to the mode of HCV transmission was remarkable ( P <0.001), wherein the main mode of transmission was through transfusion of blood or blood products. Most genotype 1 infection (53.1%) was found in the group with duration of HCV infection of 10 to 20 years and genotype 1b was independently associated with age ( P =0.001) 18. In a retrospective study of 1,208 patients in southwest China, individuals older than 40 years of age were mainly infected with genotypes 1b or 2a, whereas younger patients were predominantly infected with genotypes 3 or 6.…”

Section: Hcv Virologic and Host Features Among Chinese Patientsmentioning

confidence: 92%

“…This age divergence reflected the evolving demographics according to modes of transmission. In a study with 483 anti-HCV-positive patients from 10 provinces in China, the mean age of patients with genotype 1 and 2 was significantly older than those with genotype 3 and 6 ( P <0.05) 18. The distribution of HCV genotypes in relation to the mode of HCV transmission was remarkable ( P <0.001), wherein the main mode of transmission was through transfusion of blood or blood products.…”

Section: Hcv Virologic and Host Features Among Chinese Patientsmentioning

confidence: 98%

Current Challenges and the Management of Chronic Hepatitis C in Mainland China

Duan

Jia

Hou

et al. 2014

Journal of Clinical Gastroenterology

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Despite decreasing prevalence, new cases of hepatitis C in China are increasing recently with growing percentage of patients who are with advanced disease, aging, or not eligible for interferon-based treatments. Hepatitis C infection represents a serious public health burden. This review was based on expert’s consensus during a medical forum on hepatitis sponsored by the Beijing Wu Jie-Ping Medical Foundation. The literature searches were conducted in PubMed and critical publications in Chinese journals. Data on hepatitis C prevalence, risk factors, viral or host features, and treatment modalities were extracted and reviewed. Recent large-scale surveys reported reducing prevalence of hepatitis C to approximately 0.4% in China, partly because of regulation changes to safer medical practices and illegalizing commercial blood donations. Patient demographics evolved from being dominated by former paid blood donors to include intravenous drug users and others. Although hepatitis C genotype 1 is the most common, other genotypes are emerging in prevalence. The current standard of care is interferon-based without direct acting antivirals. However, many patients failed therapy because of high treatment costs, substantial needs to manage side effects, difficulties with treatment monitoring in the rural areas, and growing populations of elderly and cirrhotic patients. The lack of high efficacy therapies with good safety profile and low disease awareness in China resulted in increasing public burden of advanced hepatitis C disease. Despite significant reduction of hepatitis C prevalence, iatrogenic, nosocomial, and community transmissions are still significant. In addition to promoting disease awareness, interferon-free regimens are needed to reduce the public health burden.

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“…The geographical distribution of HCV genotypes has been investigated by a variety of studies in China, however the results are paradoxical. A number of studies show that HCV genotype 1b is the most widely distributed genotype (23), and is most predominant in the North (Beijing, 56.8%), East (Shanghai, 69.1%) and Southwest (Chongqing, 32.9%), while genotype 2a is most predominant in the Northwest (Wuwei, 59.1%) (24)(25)(26)(27). The differences in the distribution of HCV genotypes may arise from the varying detection methods and small sample size used among the literature.…”

Section: Discussionmentioning

confidence: 99%

Correlation between the genetic variations in interleukin 28B and chronic hepatitis C virus genotypes in the Chinese population

Mao

Zhang

Chen

et al. 2014

Molecular Medicine Reports

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Abstract. Genetic variations at the interleukin 28B (IL-28B) locus and chronic hepatitis C virus (HCV) genotypes are significant factors in predicting the therapeutic outcome for HCV infection. The present study aimed to determine the geographical distribution of HCV genotypes and single nucleotide polymorphisms (SNPs) associated with IL-28B in Chinese patients infected with HCV. The gene frequencies of 13 types of IL-28B SNPs and HCV genotypes were investigated in 1,014 patients infected with HCV, who were recruited from varying regions of China. The correlation between the SNPs of IL-28B, the HCV genotypes and age, gender and geographical location were investigated. The data revealed geographical differences in age, gender and HCV genotypes in the Chinese HCV patients. HCV genotype 1 was distributed extensively and had a higher incidence compared with other HCV genotypes in all regions, with the exception of South (38%) and Northwest China (45.6%). A gender differences also existed (P<0.01). The distribution of genotype 6 was lower compared with other HCV genotypes in the majority of the regions (P<0.01). In middle-aged patients, the number of male patients was higher than the number of female patients in North and South China, which was the opposite of the results found in the other regions. There were no geographical differences in IL-28B SNPs in Chinese HCV-infected populations. Notably, there were significant differences between HCV genotype 1 and 2 in the genotype percentages of the majority of SNPs (P<0.01). In conclusion, a geographical distribution in HCV genotypes and a correlation between HCV genotypes and IL-28B SNPs have been identified, and indicate that these variants may be associated with spontaneous and treatment-induced HCV clearance.

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Distribution of hepatitis C virus genotypes in Chinese patients with chronic hepatitis C: Correlation with patients’ characteristics and clinical parameters

Abstract: The main HCV subtype was genotype 1b in Chinese patients. The prevalence of HCV genotypes was correlated with age and the mode of HCV transmission. Genotype 3a and 6 may become an increasing threat in the future.

Cited by 17 publications

References 25 publications

Increased prevalence of hepatitis C virus subtype 6a in China: a comparison between 2004–2007 and 2008–2011

Increased prevalence of hepatitis C virus subtype 6a in China: a comparison between 2004–2007 and 2008–2011

Current Challenges and the Management of Chronic Hepatitis C in Mainland China

Correlation between the genetic variations in interleukin 28B and chronic hepatitis C virus genotypes in the Chinese population

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