Distribution of High-Density Lipoprotein Subfractions and Hypertensive Status

Zhang, Yan; Li, Sha; Xu, Rui‐Xia; Guo, Yuan‐Lin; Wu, Na‐Qiong; Zhu, Cheng‐Gang; Gao, Ying; Dong, Qian; Li, Geng; Sun, Jing; Li, Jianjun

doi:10.1097/md.0000000000001912

Cited by 12 publications

(12 citation statements)

References 26 publications

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“…31 Lower levels of less dense HDL particles were associated with hypertension in a large cohort of adults without diabetes, as well as the severity of coronary artery disease in patients presenting with angina. 54,55 Thus, the profile of increased cholesterol distribution in VLDL and LDL, and decreased distribution in more buoyant HDL, is associated with markers and outcomes of CVD, and is consistent with our CVD findings in youth with PCOS.…”

Section: Discussionsupporting

confidence: 89%

Obese adolescents with polycystic ovarian syndrome have elevated cardiovascular disease risk markers

et al. 2017

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Women with polycystic ovarian syndrome (PCOS) have evidence of subclinical cardiovascular disease (CVD). However, insulin resistance, an important factor in the development of CVD in adults, is common in adolescents with PCOS, yet data in adolescents are limited. Therefore, we sought to measure insulin resistance and CVD markers in obese youth with and without PCOS. Thirty-six PCOS and 17 non-PCOS adolescent girls who were obese, sedentary, and non-hypertensive were recruited from clinics located within the Children's Hospital Colorado. Following 3 days of controlled diet and restricted exercise, fasting plasma samples were obtained prior to a hyperinsulinemic euglycemic clamp. PCOS girls were more insulin resistant than controls (glucose infusion rate 5.24±1.86 mg/kg/min vs 9.10±2.69; p<0.001). Girls with PCOS had blood pressure in the normal range, but had greater carotid intima–media thickness (cIMT) (0.49±0.07 mm vs 0.44±0.06; p=0.038), beta stiffness index (5.1±1.3 U vs 4.4±0.9; p=0.037), and reduced arterial compliance (1.95±0.47 mm2/mmHg × 10−1 vs 2.13±0.43; p=0.047). PCOS girls had a normal mean lipid profile, yet had a more atherogenic lipoprotein cholesterol distribution and had persistent elevations of free fatty acids despite hyperinsulinemia (68±28 μmol/mL vs 41±10; p=0.001), both potential contributors to CVD. Free fatty acid concentrations correlated best with all CVD markers. In summary, adolescent girls with PCOS have greater cIMT and stiffer arteries than girls without PCOS, perhaps related to altered lipid metabolism, even when clinical measures of blood pressure and cholesterol profiles are ‘normal’. Therefore, management of adolescent PCOS should include assessment of CVD risk factor development.

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Section: Discussionsupporting

confidence: 89%

Obese adolescents with polycystic ovarian syndrome have elevated cardiovascular disease risk markers

et al. 2017

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“…reported that large HDL-C levels were inversely associated with the risk of acute myocardial infarction and may thus be protective factors 28 . Besides that, our recent studies have revealed that large HDL subfraction was negatively associated with several cardiovascular risk factors, such as serum uric acid 29 and hypertension 30 . In the current study, we found that only large HDL subfraction was negatively associated with very early CAD susceptibility, which may provide additive information regarding the different role of specific subfraction on the very early CAD incidence.…”

Section: Discussionmentioning

confidence: 97%

HDL subfractions and very early CAD: novel findings from untreated patients in a Chinese cohort

Zhang

Zhu

et al. 2016

Sci Rep

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Coronary artery disease (CAD) in very young individuals is a rare disease associated with poor prognosis. However, the role of specific lipoprotein subfractions in very young CAD patients (≤45 years) is not established yet. A total of 734 consecutive CAD subjects were enrolled and were classified as very early (n = 81, ≤45), early (n = 304, male: 45–55; female: 45–65), and late (n = 349, male: >55; female: >65) groups. Meanwhile, a group of non-CAD subjects were also enrolled as controls (n = 56, ≤45). The lipoprotein separation was performed using Lipoprint System. As a result, the very early CAD patients have lower large high-density lipoprotein (HDL) subfraction and higher small low-density lipoprotein (LDL) subfraction (p < 0.05). Although body mass index was inversely related to large HDL subfraction, overweight did not influence its association with very early CAD. In the logistic regression analysis, large HDL was inversely [OR 95% CI: 0.872 (0.825–0.922)] while small LDL was positively [1.038 (1.008–1.069)] related to very early CAD. However, after adjusting potential confounders, the association was only significant for large HDL [0.899 (0.848–0.954)]. This study firstly demonstrated that large HDL subfraction was negatively related to very early CAD suggestive of its important role in very early CAD incidence.

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“…Higher values of small LDL particles and lower values of large HDL particles, as well as a reduction in LDL size, were reported in incident diabetes [10]. Decreased large HDL particles and increased small HDL particles were found in patients with hypertension [23]. However, as previously mentioned, it is still a matter of debate which subfraction of HDL is more atheroprotective [6], with reports referring a positive association between HDL3 and protection from CAD [24], in opposition to the above-referred reports in the opposite direction.…”

Section: Discussionmentioning

confidence: 99%

The Protective Role of Adiponectin for Lipoproteins in End-Stage Renal Disease Patients: Relationship with Diabetes and Body Mass Index

Coimbra

Reis

Nunes

et al. 2019

Oxidative Medicine and Cellular Longevity

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Cardiovascular disease (CVD) events are the main causes of death in end-stage renal disease (ESRD) patients on dialysis. The number and severity of CVD events remain inappropriate and difficult to explain by considering only the classic CVD risk factors. Our aim was to clarify the changes and the relationship of lipoprotein subfractions with other CVD risk factors, namely, body mass index (BMI) and adipokines, inflammation and low-density lipoprotein (LDL) oxidation, and the burden of the most prevalent comorbidities, diabetes mellitus (DM) and hypertension (HT). We studied 194 ESRD patients on dialysis and 22 controls; lipid profile, including lipoprotein subpopulations and oxidized LDL (oxLDL), C-reactive protein (CRP), adiponectin, leptin, and paraoxonase 1 activity were evaluated. Compared to controls, patients presented significantly lower levels of cholesterol, high-density lipoprotein cholesterol (HDLc), LDLc, oxLDL, and intermediate and small HDL and higher triglycerides, CRP, adiponectin, large HDL, very-low-density lipoprotein (VLDL), and intermediate-density lipoprotein- (IDL) B. Adiponectin levels correlated positively with large HDL and negatively with intermediate and small HDL, oxLDL/LDLc, and BMI; patients with DM (n=17) and with DM+HT (n=70), as compared to patients without DM or HT (n=69) or only with HT (n=38), presented significantly higher oxLDL, oxLDL/LDLc, and leptin and lower adiponectin. Obese patients (n=45), as compared to normoponderal patients (n=81), showed lower HDLc, adiponectin, and large HDL and significantly higher leptin, VLDL, and intermediate and small HDL. In ESRD, the higher adiponectin seems to favor atheroprotective HDL modifications and protect LDL particles from oxidative atherogenic changes. However, in diabetic and obese patients, adiponectin presents the lowest values, oxLDL/LDLc present the highest ones, and the HDL profile is the more atherogenic. Our data suggest that the coexistence of DM and adiposity in ESRD patients on dialysis contributes to a higher CVD risk, as showed by their lipid and adipokine profiles.

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Distribution of High-Density Lipoprotein Subfractions and Hypertensive Status

Abstract: Supplemental Digital Content is available in the text

Cited by 12 publications

References 26 publications

Obese adolescents with polycystic ovarian syndrome have elevated cardiovascular disease risk markers

Obese adolescents with polycystic ovarian syndrome have elevated cardiovascular disease risk markers

HDL subfractions and very early CAD: novel findings from untreated patients in a Chinese cohort

The Protective Role of Adiponectin for Lipoproteins in End-Stage Renal Disease Patients: Relationship with Diabetes and Body Mass Index

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