Distribution of High-Risk Human Papillomavirus Genotypes in Precancerous Cervical Lesions in Ouagadougou, Burkina Faso

Abstract

Aims: We aimed at identifying the high-risk HPV genotypes associated with high-grade dysplastic cervical lesions in Burkina Faso. The available vaccines to Burkina Faso only protect against two high risk HPV genotypes: HPV 16 and 18. Are the genotypes identified in the high-grade precancerous lesions in this survey covered by the available vaccines? Methods: The detection and genotyping of high-risk HPV have been conducted based on 118 formalin-fixed and paraffin-embedded archived tissues using the "HPV Genotypes 14 Real-TM Quant" (Sacace biotechnologies ® , Italy) kit allowing for the detection of fourteen high-risk HPV genotypes: HPV 16, 31, 18, 39, 45, 59, 33, 35, 56, 68, 51, 52, 58 and 66. Results: The prevalence of high-risk HPV infections was 48.8% based on the appropriate PCR results (21/43). The most common HPV genotypes were HPV 39 (21.7%), * Corresponding author.C. Ouédraogo et al. 197HPV 35 (13.0%) and HPV 45 (13.0%). Two cases of multiple infections between HPV 39 -45 and HPV 39 -59 have been observed. HPV 16 was not detected in this study. Conclusions: We noted a high prevalence rate for HPV 39, HPV 35 and HPV 45, which are not covered by the commercial vaccines. We also found that the prevalence of HPV 18 was very low in this study and HPV 16 was not detected.

Molecular characterization of high-risk human papillomavirus (HR-HPV) in women in Lomé, Togo

“…This population is similar to the study population of Traore et al [8] in Bobo-Dioulasso (Burkina Faso) whose age varied between 20 and 56 years with an average of 35.3 ± 0.6 years. Married women represented 48.8% of cases, which is less than the findings of Ouedraogo et al [9] that reported 76% of married women always from the same country (Burkina Faso). We found a percentage of 52.2% of women which do not use condoms.…”

Cervical Cancer Induced by Human Papillomaviruses in the Context of Africa: Contribution of Genomics

“…These prevalences were also variable according to the locality. In high-grade lesions and cancer cases, the prevalence was 48.8% and 72.31%, respectively [14,15]. Cervical cancer is the most common cancer in women worldwide in 45 countries and kills more women than all other forms of cancer in 55 countries.…”

HPV/HBV or HPV/HCV Co-Infections in Women Treated for Chronic Hepatitis at Hôpital Saint Camille in Ouagadougou, Burkina Faso

“…In Burkina Faso, cervical cancer is the second most common cancer in women, with 1132 cases and 839 deaths estimated for 2020 [6]. Several studies have already been carried out to determine the prevalence of HPV infection in the general population in different regions and towns of the country [7] [8] [9] [10], among sex workers [11] [12], among women diagnosed with precancerous lesions [13] [14] [15], in those with invasive cervical cancer [16] [17], in pregnant women [18], in adolescents [19] and in people living with Human Immunodeficiency Virus (HIV) [20] [21] [22]. However, no studies have been carried out in women with hepatitis B (HBV) and hepatitis C (HCV) infection.…”