Distribution of HLA alleles and haplotypes in Jinuo and Wa populations in Southwest China

HLA polymorphism of the Zhuang population reflects the common HLA characteristics among Zhuang-Dong language-speaking populations

“…For example, the predominant A-C-B haplotype, A*02:07-C*01:02-B*46:01, was predominant in Vietnamese as well as in some southern Chinese populations, such as the Dai, Hani, Miao, Bouyei, Shui, Han in Yunnan, and Han in Guangdong, but existed at low frequencies in Chinese Hui, Japanese, and Koreans. Another predominant haplotype, A*11:01-C*08:01-B*15:02, was also predominant in Vietnamese and some Chinese populations, such as the Bulang, Dai, Hani, Shui, Han in Yunnan, and Han in Guangdong, who were located in southern China (Tokunaga et al, 1997;Middleton et al, 2004;Chen et al, 2007;Hong et al, 2007;Ogata et al, 2007;Trachtenberg et al, 2007;Hoa et al, 2008;Shi et al, 2008;2010a;2010b;Wen et al, 2008;Yao et al, 2009). Based on the HLA alleles, haplotypes, and neighbor-joining tree analysis, we concluded that the Zhuang is a typical southern Chinese population.…”

“…For example, A*11:01-B*15:02-DRB1*12:02 was common in southern populations of East Asia (Ogata et al, 2007;Trachtenberg et al, 2007;Hoa et al, 2008;Shi et al, 2008;2010a;2010b;Wen et al, 2008;Gendzekhadze et al, 2009;Yao et al, 2009); however, it was not identified in the Zhuang. Instead, A*11:01-B*15:02-DRB1*15:01 was predominant in the Zhuang, but was not identified in other East Asian populations.…”

“…Nei's standard genetic distances among 18 populations were calculated based on HLA-A, HLA-B, and HLA-DRB1 allele frequencies and a neighbor-joining tree was constructed using Mega4.0 software (Tamura et al, 2007). Frequency data for other Asian populations were obtained from previous studies, as follows: Wa and Jinuo (Shi et al, 2008), Bouyei (Imanishi et al, 1992;Chen et al, 2007), Maonan (Ogata et al, 2007), Han in Taiwan (Wen et al, 2008), Han in Hongkong (Hardy et al, 1997), Han in Guangdong (Trachtenberg et al, 2007), Menba (Zhang et al, 2005), Tibetan (Lai et al, 1999;, Hui (Yu et al, 2002;Hong et al, 2007), Han in Beijing (Sun et al, 1997;Deng et al, 2005), Han in Northern (Yang et al, 2006), Dai (Shi et al, 2010a), Han in Yunnan (Yao et al, 2009), and Bulang and Hani (Shi et al, 2010b). Fig.…”

HLA-C polymorphisms and PCR dropout in exons 2 and 3 of the Cw*0706 allele in sequence-based typing for unrelated Chinese marrow donors

“…Sequencing-based typing (SBT) for HLA-C is applied as a confirmatory test only if the unrelated donor/receipt pair matched at HLA-A, -B, and -DRB1. There have been many reports on HLA-A, -B, and -DRB1 about their allelic diversity and novel polymorphisms in Chinese Han populations [12][13][14], but very few studies have been focused on HLA-C on a large sample size (e.g., more than 1000 samples). Compared with other HLA loci our knowledge on HLA-C in Chinese populations is rather limited.…”

Nasopharyngeal Carcinoma (NPC) Related Human Leukocyte Antigen (HLA) Haplotype Sharing among Southern East Asian Population

“…The HLA allele frequency at four digit level for HLA-A, -B and -DRB1 were obtained from nineteen populations both from previous studies {Javanese (Indonesia), 7 Kihn (Vietnamese), 20 Han (Yunnan, China), 21 Maonan (Guangxi, China), 22 Dai (Yunnan, China), 23 Hani (China), 24 Bulang (China), 24 Jinuo (China), 25 and Wa (China) 25 } and from www.allelefrequencies.net {Malay, Han (Singapore), Thai, Han (Yunnan, China), Jinuo (China), Wa (Yunnan, China), Han (Hong Kong), Han (Guangdong, China), Taiwanese, Han (Fengyuandong, China), Maonan (Guangxi, China), Buyi (China), Nu (China), and Lisu (Yunnan, China)}. Only populations with minimum sample size of 100 individuals were selected (Fig.…”