Distribution of HLA-B*27 Subtypes in Patients with Ankylosing Spondylitis in Local Population

Lodhi, Noor Afshan; Bashir, Muhammad M.; Tipu, Hamid Nawaz; Hussain, Muhammad

doi:10.29271/jcpsp.2019.05.418

Cited by 5 publications

(4 citation statements)

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“…10,11 Similarly, in a study on the Pakistani population by Lodhi et al, the HLA B2707 allele was more frequent in the healthy population in comparison to AS patients, whereas the B2706 allele was present only in the healthy group. 12 All these findings augment the results of the current study showing presence of HLA B27 more prevalent in healthy populations than in JIA patients, possibly due to the geographical distribution of the gene. In a study by Stanevicha et al, HLA B27 antigen was linked to JIA-ERA, oligoarthritis and polyarthritis.…”

Section: Discussionsupporting

confidence: 88%

The possible protective role of HLA B27 and relevant immune markers in Juvenile Idiopathic Arthritis patients

Shahzad,

Tahir,

Shahzad

et al. 2024

Pak J Med Sci

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Background & Objectives: JIA is a disease with different immunological characteristics and a complicated genetic foundation. HLA B27 is a risk factor for the development of JIA, and its impact on immunopathogenesis of the disease is also an area of interest. To determine whether HLA B27 and immune markers varied between JIA patients and healthy population. Methods: This comparative cross-sectional study was conducted at Immunology Department of University of Health sciences (UHS), Lahore from February 2018 till August 2021. A total of (71) JIA patients and (34) healthy controls were enrolled. B cells were enumerated by flowcytometry, ELISA was used for serum cytokines estimation and HLA B27 allele was detected by SPSS polymerase chain reaction. Results: The HLA B27 allele was significantly more in the control group than in the patient group, suggesting it is a protective allele to prevent JIA. Peripheral blood B cell counts and percentages were significantly lower in the HLA B27 positive group than in the HLA B27 negative group of control population. Serum cytokine levels were not significantly different between the HLA B27 positive and HLA B27 negative allele of the two study populations. Conclusion: In this study B cells are different between the two groups of control population however; serum cytokines are comparable between the study groups. Though, it was indicated that HLA B27 may be a preventive allele in the onset of JIA. doi: https://doi.org/10.12669/pjms.40.5.7915 How to cite this: Shahzad F, Tahir R, Shahzad F, Afzal N. The possible protective role of HLA B27 and relevant immune markers in Juvenile Idiopathic Arthritis patients. Pak J Med Sci. 2024;40(5):---------. doi: https://doi.org/10.12669/pjms.40.5.7915 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Discussionsupporting

confidence: 88%

The possible protective role of HLA B27 and relevant immune markers in Juvenile Idiopathic Arthritis patients

Shahzad,

Tahir,

Shahzad

et al. 2024

Pak J Med Sci

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“…In a Toronto cohort, HLA-B27 was one genetic marker associated with disease severity in PsA, but HLA antigens HLA-B39, and HLA=DQw3 were also associated with disease progression in the same cohort, while HLA-DR7 was "protective" (9) In the same cohort HLA-B39 was associated with progression in early disease (9). There are few population based data on HLA frequencies in SA, and particularly Pakistani, populations, though one small study suggested a low frequency (<3%) of the HLA-B27 genotype, and was a different sub-type (B*2707) (10). More recent genome wide studies have focussed more on susceptibility genes rather than disease severity genes.…”

Section: Discussionmentioning

confidence: 91%

A clinical and radiographic comparison of patients with psoriatic arthritis from different ethnic backgrounds

et al. 2020

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Objectives There are few papers concerning ethnic differences in disease expression in PsA, which may be influenced by a number of genetic, lifestyle and cultural factors. This article aims to compare clinical and radiographic phenotypes in people of South Asian (SA) and North European (NE) origin with a diagnosis of PsA. Methods This was a cross-sectional observational study recruiting patients of SA and NE origin from two hospitals in a well-defined area in the North of England. Results A total of 58 SA and 48 NE patients were recruited. SA patients had a more severe clinical phenotype with more tender (median 5 vs 2) and swollen (median 1 vs 0) joints, more severe enthesitis (median 3 vs 1.5), more patients with dactylitis (24% vs 8%), more severe skin disease (median PASI 2.2 vs 1) and worse disease activity as measured by the composite Psoriatic Arthritis Disease Activity Score (mean 4.5 vs 3.6). With regards to patient-completed measures, SA patients had worse impact with poorer quality of life and function (mean HAQ 0.9 vs 0.6; mean PsAQoL 10.8 vs 6.2; mean 36-item short form physical component score 33.5 vs 38.9). No significant differences in current MTX and biologics use were found. Conclusions SA patients had a worse clinical phenotype and worse impact of disease than NE patients. Further studies are needed to confirm and explore the reasons behind these differences.

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“…The B* 2706 allele appears to have a protective role in the population studied because it was found in healthy controls. HLA-B*27:03 and 07 are the predominant subtypes in Punjabis and Pathans, respectively (3).…”

Section: Introductionmentioning

confidence: 99%

Determination of prevalence of HLA-B27 in patients with backache at Armed Forces Institute of Pathology (AFIP), Rawalpindi

Haris,

Maqsood,

Tipu

et al. 2024

Preprint

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Background HLA-B27 is a class I MHC protein that is associated with different diseases collectively called, spondyloarthropathies. It includes; 2. Ankylosing spondylitis, which causes inflammation of the bones in your spine 3. Reactive arthritis, which causes inflammation of your joints, urethra, and eyes, and in some cases lesions on your skin 4. Juvenile rheumatoid arthritis 5. Anterior Uveitis, which causes swelling and irritation in the middle layer of your eye Objectives To determine the prevalence of HLA-B27 in patients with backache at the Armed Forces Institute of Pathology in Rawalpindi. This descriptive cross-sectional study was conducted between June 2020 and Nov 2020. Material and methods Of the 243 patients, 167 males and 76 females were tested for HLA-B27 during the study period. Venous blood samples (3 mL) were collected in EDTA tubes and processed for HLA-B27 gene identification on the cell surface. A two-color flow cytometry panel was used to analyze samples using a BD FACS Canto II flow cytometer on BD FACS Diva software. The dot plot was created using an isotype control in four quadrants, and positive and negative populations of cells were identified. Results A total of 243 patients were analyzed for the presence of HLA-B27 using flow cytometry. Of the 243 patients, 167 were male and 76 were female patient.51 male patients tested positive, with a positivity rate of 30.53% among the male population and 20.98% among the general population. In contrast to the male population, 12 female patients tested positive for the HLA-B27 gene, with a positivity rate of 15.78% among the female population and 4.93% among the general population. The total positivity rate was 25.92%, with a higher prevalence in the male population included in this study. Conclusion All individuals tested for HLA B27 were included in this study. This study showed that positivity rate of HLA-B27 is more in males with a percentage of 20.98% as compared to female population (4.93%).

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Distribution of HLA-B*27 Subtypes in Patients with Ankylosing Spondylitis in Local Population

Abstract: Objective: To compare the distribution of HLA-B*27 subtypes in healthy controls and in ankylosing spondylitis (AS) patients of different ethnic groups from Pakistan.

Cited by 5 publications

References 13 publications

The possible protective role of HLA B27 and relevant immune markers in Juvenile Idiopathic Arthritis patients

The possible protective role of HLA B27 and relevant immune markers in Juvenile Idiopathic Arthritis patients

A clinical and radiographic comparison of patients with psoriatic arthritis from different ethnic backgrounds

Determination of prevalence of HLA-B27 in patients with backache at Armed Forces Institute of Pathology (AFIP), Rawalpindi

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