Distribution of HLA‐B27 in Romanian spondyloarthritides patients

Popa, Otilia; Bojincă, Mihai; Bojincă, V.; Ciofu, C.; Dutescu, Monica Irina; Bardan, Alice; Sfrenț-Cornățeanu, Roxana; Petřek, Martin; Bara, C.; Popa, Luis Ovidiu

doi:10.1111/j.1744-313x.2010.00945.x

Cited by 6 publications

(11 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the control group of healthy subjests from Vojvodina, the HLA- B27 marker was detected in 14 of 224 individuals (6.2%). In the AS group, our findings in the present study corroborate other studies, which point to a strong association between HLA-B27 and AS [2,8,23,24]. The distribution of HLA-B27 in our sample of AS patients from Vojvodina is similar from that found in populations of Tunisia, (62.0%), Italy (76.0–68.0%) and Turkey (70.0%) [2,21].…”

Section: Discussionsupporting

confidence: 92%

“…In the AS group, our findings in the present study corroborate other studies, which point to a strong association between HLA-B27 and AS [2,8,23,24]. The distribution of HLA-B27 in our sample of AS patients from Vojvodina is similar from that found in populations of Tunisia, (62.0%), Italy (76.0–68.0%) and Turkey (70.0%) [2,21]. In contrast, the HLA-B27 frequency in AS patients from Vojvodina was lower than that reported from different European countries: Spain-Galicia (94.3%), United Kingdom (90.2–94.0%), Norway (north) (93.0%), Finland (93.0%), Hungary (92.7%), Bulgaria (88.0%), Spain (84.4%), Germany (82.0%) and Romania (72.1%) [2].…”

Section: Discussionsupporting

confidence: 92%

“…The distribution of HLA-B27 in our sample of AS patients from Vojvodina is similar from that found in populations of Tunisia, (62.0%), Italy (76.0–68.0%) and Turkey (70.0%) [2,21]. In contrast, the HLA-B27 frequency in AS patients from Vojvodina was lower than that reported from different European countries: Spain-Galicia (94.3%), United Kingdom (90.2–94.0%), Norway (north) (93.0%), Finland (93.0%), Hungary (92.7%), Bulgaria (88.0%), Spain (84.4%), Germany (82.0%) and Romania (72.1%) [2]. Since the number of our RA and PA patients was small, the HLA-B27 frequency (33.3%) as well as (RR =7.5 and EF =0.288), values we found may not reflect the real situation, as implied also by the suboptimal statistical power of this part of the study.…”

Section: Discussionsupporting

confidence: 84%

“…Spondyloarthropathies comprise several disorders that are more heterogenous clinically and where genetic susceptibility is likely to be more complex and variable [3]. The association degree varies markedly among different diseases of this group and also between different populations [2]. Association of AS and HLA-B27 remains one of the strongest known association of diseases with HLA-B27.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Human Leukocyte Antigen-B27 and Disease Susceptibility in Vojvodina, Serbia

Vojvodic

Ademović-Sazdanić²,

Busarcevic³

2012

Balkan Journal of Medical Genetics

View full text Add to dashboard Cite

There are numerous studies showing the role of human leukocyte antigens (HLAs) related with susceptibility or resistance to certain diseases. The aim of this study was to determine the association of HLA-B27 with ankylosing spondylitis (AS), polyarthralgia, lumboishialgia, acute anterior uveitis (AAU), psoriatic arthritis (PA), synovitis coxae and rheumatoid arthritis (RA) in patients from Vojvodina, Serbia. An HLA I class typing was performed by the serological immunomagnetic two-color fluorescence method using peripheral blood T lymphocytes in 97 patients and 224 healthy controls from the population of Vojvodina, Serbia. We calculated HLA-B27 frequencies, relative risk (RR), ethiologic fraction (EF), e.g., population attributive risk, when RR was greater than 1, while, preventive fraction (PF) was calculated when RR was lower than 1. This study revealed the strongest association of AS with HLAB27 antigen: RR = 25.0, while the EF was greater than 0.15, respectively. The χ2 test showed the significant difference (p <0.05) in HLA-B27 in patients with AS in comparison to controls (χ2 = 52.5). It was concluded that there is a positive association of HLA-B27 with AS and that HLA-B27 can serve as a marker for predisposition to diseases.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 84%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Human Leukocyte Antigen-B27 and Disease Susceptibility in Vojvodina, Serbia

Vojvodic

Ademović-Sazdanić²,

Busarcevic³

2012

Balkan Journal of Medical Genetics

View full text Add to dashboard Cite

show abstract

“…Belgrad'da yapılan bir çalışmada psoriazisli hastaların %9,3'ünde PsA geliştiği; HLA B27 pozitifliğinin %7 olduğu bulunmuştur 17 . Romanya'dan bir çalışmada ise HLA B27 pozitifliğinin psoriatik artritlilerde %25, kontrol grubunda %10,4 olduğu gözlenmiştir 18 . Kore'de yapılan bir araştırmada psoriasislilerin %9'unda PsA olduğu; artritlilerde HLA B27 pozitifliğinin %8 oranında görüldüğü bildirilmiştir 19 .…”

Section: Discussionunclassified

Is the HLA B27 genotype a risc faktor for psoriatic arthritis and psoriasis vulgaris?

Öğretmen¹,

Hız²,

Sılan³

et al. 2014

TURKDERM

View full text Add to dashboard Cite

Backround and Design:Psoriasis is a common inflammatory dermatological disease which may be complicated with joint involvement. It has been suggested that there is an association between HLA-B27 positivity and early onset psoriasis. The purpose of the current study was to investigate the incidence of HLA-B27 positivity in psoriasis patients with arthritis. Materials and Methods: In a total of 96 patients with psoriasis, age of onset, family history, and Psoriasis Area and Severity Index (PASI) values were recorded. The patients were evaluated with regard to physical examination (presence of arthritis), acute phase reactants, HLA-B27 positivity and joint radiographs. Control group comprised of 100 randomly selected healthy individuals. Results: Thirty (31.250%) patients were with psoriasis alone, 66 (68.75%) were with the findings of psoriasis and arthritis. Of the 66 patients, 17 (17.708%) were symptomatic (clinical and radiologic findings) and 49 (51.042%) subjects were asymptomatic (radiologic findings only). Nine patients (6 with psoriasis only and 3 with psoriatic arthritis) and 2 healthy controls were positive for HLA-B27. Conclusion: To carry HLA-B27 antigen increased the risk of psoriasis with an OR of 5.06, and clinically proven psoriatic arthritis with an OR of 10.5 compared to healthy controls. These results need confirmation in a larger group of patients with the inclusion of proper positive and healthy controls. (Turkderm 2014; 48: 131-4)

show abstract

ERAP1 and ERAP2 Gene Variations Influence the Risk of Psoriatic Arthritis in Romanian Population

Popa

Cherciu

et al. 2016

Arch. Immunol. Ther. Exp.

View full text Add to dashboard Cite

Psoriatic arthritis (PsA) is a chronic inflammatory disorder that belongs to the group of spondyloarthritis (SpA). It was found that single nucleotide polymorphisms (SNPs) of endoplasmic reticulum aminopeptidase (ERAP1 and ERAP2) genes influence the risk of ankylosing spondylitis, the most common form of SpA and the risk of psoriasis. Our purpose was to investigate the possible association of ERAP1 and ERAP2 gene SNPs with psoriatic arthritis susceptibility in Romanian population. Subsequent analyses included patients' subgroups according to HLA-B27 status. Psoriatic arthritis patients (N = 98) and random healthy controls (N = 139) were genotyped for ERAP1/2 genes SNPs rs30187, rs27044, rs2910686, and rs2248374 by TaqMan Allelic Discrimination Assays. An additional control group (N = 108; 100% HLA-B27 positive) was used for subsequent analyses. The results showed the association of rs2248374 SNP of ERAP2 gene with the risk of PsA, especially for HLA-B27 negative disease (p = 0.02; OR 1.59). ERAP2 haplotype GT (rs2248374/rs2910686) was significantly under-represented in PsA patients than in controls (43 vs. 55%; p = 0.02). The analysis of ERAP1 SNPs in HLA-B27 positive controls and PsA subgroup showed strong evidence of association for rs30187 (p = 0.005; OR 2.73) and for CC rs30187/rs27044 haplotype (47% in patients vs. 70.5% in controls; p = 0.006). In conclusion, we found a significant association of ERAP2 with PsA and HLA-B27 negative PsA, while ERAP1 association was restricted only to HLA-B27 positive disease. To our knowledge, this is the first study that investigated ERAP2 polymorphisms in relation to PsA susceptibility.

show abstract

Distribution of HLA‐B27 in Romanian spondyloarthritides patients

Cited by 6 publications

References 29 publications

Human Leukocyte Antigen-B27 and Disease Susceptibility in Vojvodina, Serbia

Human Leukocyte Antigen-B27 and Disease Susceptibility in Vojvodina, Serbia

Is the HLA B27 genotype a risc faktor for psoriatic arthritis and psoriasis vulgaris?

ERAP1 and ERAP2 Gene Variations Influence the Risk of Psoriatic Arthritis in Romanian Population

Contact Info

Product

Resources

About