Distribution of HLA class I and II genes in ankylosing spondylitis patients from Morocco

Atouf, O.; Benbouazza, Karima; Brick, C.; Saoud, Bouchra; Benseffaj, N.; Amine, Bouchra; Hajjaj–Hassouni, N.; Essakalli, M.

doi:10.1016/j.patbio.2012.01.001

Cited by 12 publications

(10 citation statements)

References 26 publications

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“…HLA-B27 was the most frequent allele associated with AS and was positive in 64% of Moroccan AS patients, suggesting that this gene is involved in the predisposition of the disease in our population. When compared to other data in the literature, this prevalence was higher to the 46.5% and 29% prevalences reported in previous Moroccan AS patients studies (16,19) and lower to the prevalences reported in European populations: 94.3% in Spanish AS patients (26), 90.2% in British AS patients (46), 90% in Greek AS patients (47), and 90.2% in Turkish AS patients (48). This difference in frequencies suggests that different genes not belonging to HLA-B27 and/or environmental factors may be involved in AS etiopathogenesis.…”

Section: Discussioncontrasting

confidence: 70%

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Polymorphisms of HLA‐A, ‐B, ‐Cw and DRB1 antigens in Moroccan patients with ankylosing spondylitis and a comparison of clinical features with frequencies of HLA‐B27*

et al. 2015

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Ankylosing spondylitis (AS) is very often associated with human leukocyte antigen (HLA), particularly HLA-B*27. However, the strength of this association and clinical features may vary in different ethnic groups. Our study aims to assess the distribution of HLA-A, -B, -Cw and DRB1 alleles in Moroccan patients with AS and to compare the clinical features of AS and the frequencies of HLA-B27 in patients from Morocco with other series. Seventy-five patients diagnosed with AS and assessed for clinical manifestations were selected and compared to 100 healthy controls. HLA class I and II antigens were typed by polymerase chain reaction sequence-specific oligonucleotide. HLA-B27 subtypes were studied by polymerase chain reaction amplification with sequence-specific primers. HLA-B27 was found in 64% of patients. It was positively associated with younger age at disease onset, family history, and uveitis while it had a negative association with late onset. Six B*27 subtypes were identified in the AS group. HLA-B*2705 and B*2702 were the most common observed subtypes. Among other HLA genes, a significant increase in the prevalence of HLA-Cw*02 and HLA-DRB*15 was found in AS patients. HLA-B27 is involved in the predisposition of AS in the Moroccan population. HLA-B*2705 and B*2702 were the predominant subtypes supporting previous reports in Caucasian spondyloarthropathies. Other HLA genes, HLA-Cw*02 and HLA-DRB1*15, seem to confer predisposing effect to the disease. However, the lower frequency of HLA-B27 compared to the literature in our study suggests the existence of different genetic and/or environmental factors in Morocco.

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Section: Discussioncontrasting

confidence: 70%

“…Such association was reported by Mahfoud et al (35) in Tunisian patients, but this allele was in linkage disequilibrium with B27. Another study on AS Moroccan patients showed the implication of HLA-DRB*11 alleles (16). Besides, we noted that DRB1*15 and DRB1*11 were relatively frequent in North Africans (36,37) as well as Europeans.…”

Section: Discussionsupporting

confidence: 51%

Polymorphisms of HLA‐A, ‐B, ‐Cw and DRB1 antigens in Moroccan patients with ankylosing spondylitis and a comparison of clinical features with frequencies of HLA‐B27*

et al. 2015

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“…Among patients, 52% were HLA‐B27 positive (HLA‐B27+). This frequency is in agreement with those observed in neighbouring Maghreb or North African populations (Amroun et al, ; Atouf et al, ; Sakly et al, ), whereas it differs from European and Asian populations (Abdelrahman et al, ; Reveille, Ball, & Khan, ). These controversial findings can be explained by the ethnic differences, and it seems that the HLA‐B27 allele frequency follows a decreasing north–south geographic gradient (Piazza, Menozzi, & Cavalli‐Sforza, ).…”

Section: Resultssupporting

confidence: 91%

Association study of copy number variants in CCL3L1, FCGR3A and FCGR3B genes with risk of ankylosing spondylitis in a West Algerian population

Dahmani

Benzaoui

Amroun

et al. 2019

Int J Immunogenetics

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Numerous single nucleotide polymorphisms (SNPs) were explored in the Algerian population to evaluate associated ankylosing spondylitis (AS) genetic risk factors, but no study has identified the impact of copy number variations (CNVs). The aim of the study was to determine whether CNVs of CCL3L1, FCGR3A and FCGR3B genes were also associated with the susceptibility of AS disease in Algerian population. The data set of the current study is composed of 81 patients with AS and 119 healthy controls. All samples were genotyped by digital droplet PCR (ddPCR). Chi‐square test and OR calculation were used to evaluate association between CNVs and AS and the risk associated with copy numbers (CN). In results, FCGR3A CN less than two copies (<2) was significantly increased in spondylitis patients (p = .0001, OR = 7.74 [2.32–25.74]). Additionally, FCGR3A CN < 2 copies association was present only in HLA‐B27 (‐) patients. We have concluded that FCGR3A deletions have an independent effect on AS regarding HLA‐B27 status. This is the first study that investigated the CCL3L1 CNVs in relation to AS risk disease. It reveals that CCL3L1 and FCGR3B CNVs may not be involved in susceptibility to AS risk in the Algerian population.

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“…A study on 100 AS Algerian patients reported a frequency of 63% (Amroun et al., ). Equivalent HLA‐B27 frequencies have been described in the North African countries: Egypt (59% (Tayel et al., )), Morocco (58% (Atouf et al., )) and Tunisia (43%, Sakly et al., ). Various ancestral genetic components in the northern Africa have been described because of a complex history of demographic events (Bekada et al., ).…”

Section: Discussionmentioning

confidence: 99%

Association of the HLA‐B27 antigen and the CTLA4 gene CT60/rs3087243 polymorphism with ankylosing spondylitis in Algerian population: A case–control study

Dahmani

Benzaoui

Amroun

et al. 2018

Int J Immunogenetics

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Ankylosing spondylitis (AS) is a complex inflammatory disease that represents a major health problem both in Algeria and worldwide. Several lines of evidence support that genetic risk factors play a role in AS etiology and the CTLA4 gene has attracted a considerable attention. In this study, we were interested in evaluating the HLA-B27 frequency and in exploring the CTLA4 gene in a sample of the North African population. The dataset of the current study is composed of 81 patients with AS and 123 healthy controls. All samples were genotyped by TaqMan allelic discrimination assay. The genetic risk of the HLA-B27 specificity and the CTLA4/CT60 polymorphism were assessed by odds ratios (OR) with 95% confidence intervals (CI). High spondylitis risk was detected for HLA-B27 allele (OR= 14.62, p = 10 ) in addition to a significant association of the CT60*G allele (OR= 1.89, p = .002). After gender and age stratifications, the association of the CT60*G allele was still significant in females sample (OR= 2.10, p = .001) and when age up to 30 years (OR = 2.21, p = .008). Interestingly, the CT60*G allele revealed an increased spondylitis risk in the B27 negative group (OR= 2.81, p = .006). The present work showed in West Algerian population that the HLA-B27 antigen and the variation in the CTLA4 3'UTR region played an important role in the ankylosing spondylitis susceptibility. The heterogeneity of this disease is deduced by genetic difference found between B27+ and B27- groups.

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Distribution of HLA class I and II genes in ankylosing spondylitis patients from Morocco

Cited by 12 publications

References 26 publications

Polymorphisms of HLA‐A, ‐B, ‐Cw and DRB1 antigens in Moroccan patients with ankylosing spondylitis and a comparison of clinical features with frequencies of HLA‐B27*

Polymorphisms of HLA‐A, ‐B, ‐Cw and DRB1 antigens in Moroccan patients with ankylosing spondylitis and a comparison of clinical features with frequencies of HLA‐B27*

Association study of copy number variants in CCL3L1, FCGR3A and FCGR3B genes with risk of ankylosing spondylitis in a West Algerian population

Association of the HLA‐B27 antigen and the CTLA4 gene CT60/rs3087243 polymorphism with ankylosing spondylitis in Algerian population: A case–control study

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Distribution of HLA class I and II genes in ankylosing spondylitis patients from Morocco

Cited by 12 publications

References 26 publications

Polymorphisms of HLA‐A, ‐B, ‐Cw and DRB1 antigens in Moroccan patients with ankylosing spondylitis and a comparison of clinical features with frequencies of HLA‐B*27

Polymorphisms of HLA‐A, ‐B, ‐Cw and DRB1 antigens in Moroccan patients with ankylosing spondylitis and a comparison of clinical features with frequencies of HLA‐B*27

Association study of copy number variants in CCL3L1, FCGR3A and FCGR3B genes with risk of ankylosing spondylitis in a West Algerian population

Association of the HLA‐B27 antigen and the CTLA4 gene CT60/rs3087243 polymorphism with ankylosing spondylitis in Algerian population: A case–control study

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Polymorphisms of HLA‐A, ‐B, ‐Cw and DRB1 antigens in Moroccan patients with ankylosing spondylitis and a comparison of clinical features with frequencies of HLA‐B27*

Polymorphisms of HLA‐A, ‐B, ‐Cw and DRB1 antigens in Moroccan patients with ankylosing spondylitis and a comparison of clinical features with frequencies of HLA‐B27*