Distribution of HLA genes and disease predisposition in Bengali speaking people from India

Abstract

Available online xxxKeywords: Marrow donor registry India HLA haplotype HLA alleles Bengali population Stem cell transplant a b s t r a c t Background: Knowledge of allele and haplotype frequencies of the HLA system is not only important in the search for unrelated bone marrow donors but it also provides useful insights to the probable susceptibility and resistance to disease as well as drug tolerance and toxicity in the Bengali population.Methods: In this study, 322 Bengali speaking donors registered with MDRI were analyzed for the HLA ABDRB1 alleles using Luminex and SSP techniques. The haplotype analysis and HW test was performed using arlequin 3.5 software.

HLA Profile of Kami Population Refutes the Earlier Proposition of Exclusive Closer Genetic Affinity of All the Gorkhas to Mongoloids

“…However, it was reported among the Pakistan Mixed Pathan [13] and the Iranian population [28]. The haplotype HLA-A*24∼B*40∼DRB1*15 which is the third most frequent haplotype among the Kami population has been observed among the Indian Bengali population [6] and Mongolian population [19].…”

“…Genomic DNA isolation was carried out by using a kit from Qiagen, and the first field resolution of HLA-A, -B and -DRB1 typing and genotype assignment were performed as described elsewhere [4]. The HLA genotype data of the comparator populations were obtained from the http://www.allelefrequencies.net database and the following publication on Kannada, Malayalam, Tamil, Telugu, Tulu [5], Indian Bengalis [6], Iranian Kurds [7], Nepalese [8], Pakistan Gujjar [9] and Lebanese [10].…”

“…The HLA genotype data of the comparator populations were obtained from the http://www. allelefrequencies.net database and the following publication on Kannada, Malayalam, Tamil, Telugu, Tulu [5], Indian Bengalis [6], Iranian Kurds [7], Nepalese [8], Pakistan Gujjar [9] and Lebanese [10].…”