Distribution of HPV 53, HPV 73 and CP8304 in genital epithelial lesions with different grades of dysplasia

Abstract

To characterize the risk of malignant progression of cervical epithelial lesions associated with human papillomavirus (HPV) types of yet unknown oncogenic potential the prevalences of these HPVs in different cervical epithelial lesions of 809 patients were determined. HPV types 53, 73, and CP8304 were detected in genital specimens of 16, 22, and 12 of the patients, respectively. The ratio of prevalence in high grade dysplastic lesions or cancers and low grade dysplastic lesions or normal specimens was calculated and compared to corresponding values of well known high-risk (HR) and low-risk (LR) HPVs. For HPV 6, 11, 16, 18, 35, and 73 a ratio of 0.1, 0.2, 5.9, 6.5, 2.5, and 2.4, respectively, was calculated. The ratios of HPV53 and CP8304 were less than 1. Moreover, in contrast to HPV73, these viruses have never been detected in cancer specimens. Thus, HPV53 and CP8304 infections are probably not associated with a high risk of carcinogenesis, while HPV73 could be another HR-HPV type.

Physical Status and Variant Analysis of Human Papillomavirus 16 in Women from Shanghai

“…The HPV types coinfected with HPV16 were HPV58, 33, 31, 45, 53, and cp8304. HPV58 is a rare high-risk type in Western countries [35,36] but was reported to be a common type in China [37], Korea [38] and some other Asian countries [39]. Its coinfection with HPV16 was often detected in high-grade and SCC samples [40].…”

“…E6-T350G (L83V) was found in 1 invasive cervical cancer sample infected with the E type HPV16 (g-60). In many previous reports, E6-T350G has been considered to be highly correlated with invasive potential and is closely related to the E type [39]. …”

Human papillomavirus genotypes in asymptomatic young women from public schools in Rio de Janeiro, Brazil

“…However, HPV 53 was never observed in cervical cancer, having been verified at a relatively high frequency in normal smears, but rarely reported in cervical dysplasia. Other investigators have classified it as a low risk type 21 . Although the frequency of types varies according to region, some types spread worldwide.…”

The Effect of Progesterone Only Contraception on the Accuracy of Cervical Cytologic interpretation

“…Progesterone is thought to promote atrophy of the epithelial cells as well as to decrease the cellular maturation pattern. 5,33 The resultant atrophy of the squamous epithelial cells and the change in expected maturational progression can mimic changes which are specific to cellular dysplasia, without actually being dysplastic.…”

“…17,97 Progesterone is thought to promote atrophy of the epithelial cells, as well as to decrease the cellular maturation pattern. 5,33 Cellular characteristics associated with the effect of progesterone exposure include curling or crowding of squamous cells, destruction of cells, and unusual morphology to cells (navicular or classically called "boat shaped"). Curling is described as a rounding or rolling of cervical cellular edges, while crowding has been defined as more than four cells in a closely spaced grouping.…”