Distribution of HPV16 and 18 intratypic variants in normal cytology, intraepithelial lesions, and cervical cancer in a Mexican population

Lizano, Marcela; Cruz-Hernández, Erick de la; Carrillo-García, Adela; García‐Carrancá, Alejandro; León-Rosales, Sergio Ponce de; Dueñas‐González, Alfonso; Hernández-Hernández, Dulce Marı́a; Mohar, Alejandro

doi:10.1016/j.ygyno.2005.12.002

Cited by 54 publications

(36 citation statements)

References 29 publications

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“…The E variant was associated significantly with cervical intraepithelial lesions grade 1 (P ¼ 0.022), contrarily to AsAi variant that showed a trend not statistically significant to an enhanced oncogenicity (37.5% in ICC cases versus 0.0% in normal cytology). As reported previously by others [Lizano et al, 1997[Lizano et al, , 2006Villa et al, 2000;Sichero et al, 2007], E variant seemed to be significantly associated with a lower risk for cervical cancer development.…”

Section: Discussionsupporting

confidence: 83%

Molecular variants of human papillomavirus type 16 and 18 and risk for cervical Neoplasia in Portugal

Pista

Oliveira

Barateiro

et al. 2007

Journal of Medical Virology

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Persistent high-risk human papillomavirus (HPV) infection is considered as the central cause of invasive cervical cancer. Specific HPV 16 and 18 sequence variations were associated with an increased risk for progression. The purpose of this study was to analyze intratypic variations of HPV 16 and 18 within the E6 gene, MY09/11 and LCR regions, and to evaluate the risk of these variants for cervical neoplasia among Portuguese women. Cervical samples from 187 HPV 16-positive and 41 HPV 18-positive women with normal epithelium, cervical intraepithelial neoplasia, or invasive cervical cancer were amplified by type-specific PCR, followed by sequence and phylogenetic analysis. Sixteen new HPV 16 and 18 patterns are described in this paper. European HPV 16 variants were the most frequent (74.3%), particularly Ep-T350 (44.4%), followed by African (16.1%), and Asian-American (9.6%). Non-European HPV 16 variants were more frequent in pre-invasive lesions than in normal tissue and low-grade lesions. However, when analyzed separately, only African variants were associated significantly with an increased risk for cervical cancer. For HPV 18, the AsAi variant showed a trend, which was not statistically significant to an enhanced oncogenicity. European variants seemed to be significantly associated with a lower risk for cervical cancer development. The distribution of HPV 16 and 18 variants was not related to age or race among women living in the same geographical region. Knowledge of variants will be important for risk determination as well as for designing primers or probes for HPV detection methods, and for appropriate cervical cancer prevention strategies.

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Section: Discussionsupporting

confidence: 83%

Molecular variants of human papillomavirus type 16 and 18 and risk for cervical Neoplasia in Portugal

Pista

Oliveira

Barateiro

et al. 2007

Journal of Medical Virology

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“…17 This data is relevant because genotype 18 is associated with more aggressive behavior and is detected mainly in high-grade lesions. 28 Our study showed the prevalence of HSV-1/HSV-2 detected by PCR; the studies reported at present of the prevalence of these viruses are mainly by serological tests. The differences in methodologies make it difficult to make a comparison of frequencies of this virus.…”

Section: Frequency Of Sexually Transmitted Infections In Mexicomentioning

confidence: 49%

Sexually transmitted pathogens, coinfections and risk factors in patients attending obstetrics and gynecology clinics in Jalisco, Mexico

Casillas-Vega

Morfín‐Otero

García

et al. 2016

SALUD PÚBLICA DE MÉXICO

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Objective. To determine the frequency of nine sexually transmitted pathogens, coinfections and risk factors in patients attending obstetrics and gynecology clinics in Jalisco, Mexico. Materials and methods. Samples from 662 patients attending obstetrics and gynecology clinics were analyzed. Treponema pallidum, HIV, and HCV were detected by serology. HPV was detected by Polimerase Chain Reaction (PCR), and its genotype was determined by Restriction Fragment Length Polymorphism (RFLP). Trichomonas vaginalis, HSV-1, HSV-2, Mycoplasma genitalium, Neisseria gonorrhoeae and T. pallidum were detected by multiplex PCR. Results. By serology, HIV frequency was 6.8%, T. pallidum was 2.26%, and HCV was 0.15%. By PCR, HPV frequency was 13.9%, (more frequent genotype was 16, 33.7%), followed by T. vaginalis (14.2%), HSV-1 (8.5%), M. genitalium (2,41%), N. gonorrhoeae (2.11%), HSV-2 (1.8%), and T. pallidum (1.05%). Patients

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“…However, we must consider in the prevention strategies other HPV types, such as HPV58, which represents an extremely important factor in our population (Lizano et al, 2006). A new HPV vaccine has been reported that covers the most frequent HPV types (Shi et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

Human Papillomavirus Genotypes among Females in Mexico: a Study from the Mexican Institute for Social Security

Salcedo¹,

Piña‐Sánchez²,

Vallejo-Ruíz³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: The aetiological relationship between human papillomavirus (HPV) infection and cervical cancer (CC) is widely accepted. Our goal was to determine the prevalence of HPV types in Mexican women attending at the Mexican Institute for Social Security from different areas of Mexico. Materials and Methods: DNAs from 2,956 cervical samples were subjected to HPV genotyping: 1,020 samples with normal cytology, 931 with low-grade squamous intraepithelial lesions (LGSIL), 481 with high grade HGSIL and 524 CC. Results: Overall HPV prevalence was 67.1%. A total of 40 HPV types were found; HPV16 was detected in 39.4% of the HPV-positive samples followed by HPV18 at 7.5%, HPV31 at 7.1%, HPV59 at 4.9%, and HPV58 at 3.2%. HPV16 presented the highest prevalence both in women with altered or normal cytology and HPV 18 presented a minor prevalence as reported worldwide. The prevalence ratio (PR) was calculated for the HPV types. The analysis of PR showed that HPV16 presents the highest association with CC, HPV 31, -33, -45, -52 and -58 also demonstrating a high association. Conclusions: The most prevalent HPV types in cervical cancer samples were -16, -18, -31, but it is important to note that we obtained a minor prevalence of HPV18 as reported worldwide, and that HPV58 and -52 also were genotypes with an important prevalence in CC samples. Determination of HPV genotypes is very important in order to evaluate the impact of vaccine introduction and future cervical cancer prevention strategies.

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Distribution of HPV16 and 18 intratypic variants in normal cytology, intraepithelial lesions, and cervical cancer in a Mexican population

Cited by 54 publications

References 29 publications

Molecular variants of human papillomavirus type 16 and 18 and risk for cervical Neoplasia in Portugal

Molecular variants of human papillomavirus type 16 and 18 and risk for cervical Neoplasia in Portugal

Sexually transmitted pathogens, coinfections and risk factors in patients attending obstetrics and gynecology clinics in Jalisco, Mexico

Human Papillomavirus Genotypes among Females in Mexico: a Study from the Mexican Institute for Social Security

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